Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

St. Jude mourns the death of Arthur W. Nienhuis, MD
St. Jude mourns the death of Arthur W. Nienhuis, MD

Gene therapy pioneer led St. Jude through unprecedented growth

Elizabeth Jane Walker

Leader, mentor, scientist, physician and gene therapy pioneer: Arthur Nienhuis' extensive legacy of science and medicine.

Common astrovirus can lead to serious health problems
Common astrovirus can lead to serious health problems

Common astrovirus can lead to serious health problems

Stacey Schultz-Cherry, PhD

This viral infection is so common nearly everyone has had it - and it can become deadly serious for those who have compromised immune systems.

Learning the connection between research and the people it helps
Learning the connection between research and the people it helps

Learning the connection between research and the people it helps

Chris Pennington

St. Jude highlights Regina Kolaitis, PhD, who shares the moment she learned about the connection between her research and the people it helped.

Reducing deep sequencing errors to find residual cancer cells
Reducing deep sequencing errors to find residual cancer cells

Reducing deep sequencing errors to find residual cancer cells

Xiaotu Ma, PhD

This new computational tool pinpoints errors in ultra deep sequencing to identify residual cancer cells that normal sequencing misses.

The current landscape and promising future of sickle cell disease therapy
The current landscape and promising future of sickle cell disease therapy

The current landscape and promising future of sickle cell disease therapy

Jeremie Estepp, MD

Major advancements in sickle cell disease therapy hold a promising future for patients, including organ preservation and a possible cure.

Are scientific citations meaningful? Scientific progress from a larger perspective
Are scientific citations meaningful? Scientific progress from a larger perspective

Are scientific citations meaningful? Scientific progress from a larger perspective

Lindsey Montefiori, PhD

Scientific citations identify valuable research. Here’s what it’s like to be a part of a lab ranked in the top 1% of citations.

Word to the wise: Don’t let the genomic data fool you
Word to the wise: Don’t let the genomic data fool you

Word to the wise: Don’t let the genomic data fool you

Mary Powers

In the world of genomics, this computational biologist recommends these simple things before interpreting the data.

How to calm the cytokine storm in COVID-19 and beyond
How to calm the cytokine storm in COVID-19 and beyond

How to calm the cytokine storm in COVID-19 and beyond

Rebecca Tweedell, PhD

Some COVID-19 infections can create a molecular storm inside your body that can be fatal. This research team may have found a way to stop it.

New clues about the machinery of brain development
New clues about the machinery of brain development

New clues about the machinery of brain development

David J. Solecki, PhD

The nature of brain development reveals that these two things are key – and also may hold clues to fighting childhood brain cancers.

Why do many promising experimental drugs fail? Data-driven research may hold the answer
Why do many promising experimental drugs fail? Data-driven research may hold the answer

Why do many promising experimental drugs fail? Data-driven research may hold the answer

Erin Podolak, MA

G-protein-coupled receptors are a popular target for drug therapies. This researcher is finding out why some drugs targeting GPCRs fail.