Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

New clues about the machinery of brain development
New clues about the machinery of brain development

New clues about the machinery of brain development

David J. Solecki, PhD

The nature of brain development reveals that these two things are key – and also may hold clues to fighting childhood brain cancers.

Why do many promising experimental drugs fail? Data-driven research may hold the answer
Why do many promising experimental drugs fail? Data-driven research may hold the answer

Why do many promising experimental drugs fail? Data-driven research may hold the answer

Erin Podolak, MA

G-protein-coupled receptors are a popular target for drug therapies. This researcher is finding out why some drugs targeting GPCRs fail.

Changing the trajectory of flu for the sickest patients
Changing the trajectory of flu for the sickest patients

Changing the trajectory of flu for the sickest patients

David Boyd, PhD

Research reveals that supportive tissue in the lungs helps coordinate the immune response to flu by regulating access to the tissue and inflammation in the lungs.

It is better to be safe than fast when it comes to the development of a COVID-19 vaccine.
It is better to be safe than fast when it comes to the development of a COVID-19 vaccine.

COVID-19 vaccine development: better safe than fast

Stacey Schultz-Cherry, PhD

This is the most important thing to remember about vaccines for COVID-19 and other diseases going through clinical trials.

Can common nasal bacteria be targeted to slow flu transmission? Maybe.
Can common nasal bacteria be targeted to slow flu transmission? Maybe.

Can common nasal bacteria be targeted to slow flu transmission? Maybe.

Mary Powers

This new study shows that flu transmission and infection could be slowed or prevented by this simple technique.

T-Cell therapy may bridge treatment gap for pediatric acute myeloid leukemia
T-Cell therapy may bridge treatment gap for pediatric acute myeloid leukemia

T-Cell therapy may bridge treatment gap for pediatric acute myeloid leukemia

Paulina Velasquez, MD

This clinical trial may be the key for leukemia patients getting a curative bone marrow transplant.

SMARCB1: Genetic ‘canary in a coal mine’ sparks research
SMARCB1: Genetic ‘canary in a coal mine’ sparks research

SMARCB1: Genetic ‘canary in a coal mine’ sparks research

Erin Podolak, MA

Scientist spent more than a decade finding out how this genetic mutation causes different cancers.

Childhood Solid Tumor Network moves to the cloud with additional data and analytic tools
Childhood Solid Tumor Network moves to the cloud with additional data and analytic tools

Childhood Solid Tumor Network moves to the cloud with additional data and analytic tools

Mary Powers

Scientists interested in studying pediatric solid tumors now have this comprehensive, interactive online shop for patient-derived tumor information.

Unraveling the ambiguity of risk for childhood cancer survivors
Unraveling the ambiguity of risk for childhood cancer survivors

Unraveling the ambiguity of risk for childhood cancer survivors

Erin Podolak, MA

Clinical specialists are learning this about the future for childhood cancer survivors and how to help them.

Staff scientists in core research facilities accelerate and broaden biomedical discovery
Staff scientists in core research facilities accelerate and broaden biomedical discovery

Staff scientists in core research facilities accelerate and broaden biomedical discovery

Gary Bridgman

These labs are highly specialized and deliver researchers access to advanced and speedy scientific results.