Clinical

Find out how research at St. Jude underlies clinical progress in the care and treatment of cancer, blood disorders, neurological disease and more. 

What’s the right way to talk about prognosis?

Heather Johnson

Researchers at St. Jude are investigating how to approach difficult conversations about prognosis with patients and their families.

Charles Mullighan
Charles Mullighan

Blinatumomab added to chemotherapy improves survival for adults with acute lymphoblastic leukemia

Alex Generous, PhD

St. Jude scientists contributed to a phase 3 clinical trial showing that blinatumomab added to chemotherapy is effective against leukemia in adults.

Building a sturdy foundation for childhood cancer survivors to reduce risk of major adverse cardiovascular events (MACE)

Paige Rishel

Childhood cancer survivors are at an increased risk of major adverse cardiovascular events, making safeguarding heart health a priority.

man and woman standing before computer monitor
man and woman standing before computer monitor

Revealing the unseen symptom burden in childhood cancer survivors

Emilia Asante, PhD

Factors like family anxiety and neighborhood adversity contribute to symptom burden in childhood cancer survivors and the need for comprehensive care.

Man and woman talking while standing next to a table.
Man and woman talking while standing next to a table.

Clinical trial disentangles immune issues and boosts anti-cancer effect of bone marrow transplantation

Brian O'Flynn, PhD

Phase II clinical trial results show promise in reducing graft-versus-host disease

Artistic rendering showing calendar months going by from left to right, with three versions of a person with sickle cell disease experiencing worse outcomes the longer they take to transition to adult care.
Artistic rendering showing calendar months going by from left to right, with three versions of a person with sickle cell disease experiencing worse outcomes the longer they take to transition to adult care.

Shortening the gap between pediatric and adult care improves sickle cell outcomes

Alex Generous, PhD

Closing the time gap between pediatric and adult care could have significant benefits for patients.

A man and a woman sitting on a hospital bed and talking to each other
A man and a woman sitting on a hospital bed and talking to each other

Bone marrow transplantation for sickle cell disease improves myocardial fibrosis

Erin Podolak, MA

St. Jude scientists have found for the first time that myocardial fibrosis caused by sickle cell disease can actually be improved by bone marrow transplantation.

Abstract image of a brain in a cave
Abstract image of a brain in a cave

Uncovering the source of a “silent” syndrome

Brian O'Flynn, PhD

Discover the neuronal interactions at the center of posterior fossa syndrome

Doctor talking to patient in hospital room
Doctor talking to patient in hospital room

Boot camp trains sickle cell disease ‘pain crises champions’ to improve patient care

Alex Generous, PhD

St. Jude and UTHSC are training nurses worldwide how to better care for people with sickle cell disease.

Long-acting injectable HIV drugs safe for treating adolescents

Alex Generous, PhD

Learn how long-lasting drugs offer hope for adolescent with HIV.