Research
Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.
Metabolic processes may yield a new therapeutic window for hard-to-treat brain tumors
In his laboratory at St. Jude, Stephen Mack, PhD, is researching how metabolic and epigenetic pathways might be perturbed to help treat DIPG, a lethal childhood brain tumor.
St. Jude symposium to focus on hippocampus imaging in childhood cancer patients and survivors
St. Jude Children’s Research Hospital’s Department of Diagnostic Imaging is hosting their 3rd Annual Scientific Symposium, “Imaging Structure and Functions of the Hippocampus” on February 25.
Pain may be a risk factor for learning problems in childhood cancer survivors
Researchers are focusing on treatment-related pain as another way to reduce the risk of learning and memory problems in survivors of childhood leukemia.
CoNGA: Deciphering the dance of T-cell differentiation
St. Jude scientists have created an algorithm to help group T-cells by their function by evaluating two different types of data, T-cell receptor sequences and gene expression.
St. Jude biostatisticians create a novel clinical trial design software
Description: St. Jude biostatisticians have developed a new method for designing phase 2 clinical trials with a small sample size. The approach uses a mathematical model called Bayesian probability . The researchers created free software to implement the process.
Bringing Chemistry to Medicine: Transcription therapy symposium is set for July 22 and 23
St. Jude will host the virtual Bringing Chemistry to Medicine Symposium July 22–23. The inaugural event in 2020 prompted a researcher in India to become a visiting scientist at St. Jude. Register for the event.
Identifying risks and restrictions: Rehabilitation and cancer survivorship
Kristin Lyons, director of Rehabilitation Services, and Jessica Sparrow, Lead Occupational Therapist, worked as part of a team of oncology rehabilitation providers from pediatric institutions across the country to co-author a recent Seminars in Oncology Nursing article, which provides a comprehensive overview of rehabilitation screening, assessment, and intervention for children with cancer.
Getting to the bottom of a medulloblastoma mystery
Posterior fossa syndrome develops in some children following surgery for the brain tumor medulloblastoma. St. Jude research offers fresh insight into the mysterious syndrome and advice on how to avoid it.
For the growing number of childhood cancer survivors, five-year survival is just the beginning
As cancer survivorship changes, new benchmarks must be set to redefine survivorship research and treatment success.
The heart of the matter – cancer survivors and heart disease
Cancer treatments can result in damage to the heart both during treatment and years following completion of therapy. As many cancer survivors are now living longer into adulthood, we’re gaining a better understanding of some of the late effects of cancer treatments that we weren’t able to observe before.