Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Michael McNeil, MD, MPH
Michael McNeil, MD, MPH

Global palliative care requires on-the-ground understanding

Michael J. McNeil, MD

The ADAPT study revealed barriers that stand in the way of palliative care in Latin America.

Lab table
Lab table

Liver toxicity and ALL: Genomics drive variability between patients

Erin Podolak, MA

Research reveals how inherited genetic variants can contribute to liver toxicity after chemotherapy.

Qingfei Pan and Jiyang Yu
Qingfei Pan and Jiyang Yu

Math test points metastatic breast cancer treatment in the right direction

Alex Generous, PhD

St. Jude computational biologists created a computational score predicting cancer drug sensitivity to HDAC6 inhibitors in a promising phase Ib clinical trial.

Scientist in lab wearing gloves and with bunsen burner on
Scientist in lab wearing gloves and with bunsen burner on

On the road to resistance: How bacteria can win the game of life ‘with a little help from their friends’

Erin Podolak, MA

St. Jude scientists have learned that bacteria are more successful at developing antibiotic resistance when they swap genes through recombination.

Hearing soundboard
Hearing soundboard

New model mimics progression of pediatric bone marrow failure

Alex Generous, PhD

St. Jude scientists have created the first model that faithfully recapitulates details of pediatric bone marrow failure.

image of cerebral organoids
image of cerebral organoids

CDK6: A well-known kinase commits a new ‘crime’ connecting outer radial glia to microcephaly

Erin Podolak, MA

Microcephaly is a rare neurodevelopmental condition in which a baby’s head is much smaller than expected because the brain did not develop properly or stopped developing during pregnancy. St. Jude researchers identified cells in the outer radial glia in the developing brain that play an important role in microcephaly.

Group of people in lab
Group of people in lab

Environment helps fuel hepatoblastoma in premature infants

Erin Podolak, MA

The incidence of pediatric and adult liver cancer is increasing worldwide. Research suggests how premature birth may influence the risk for children.

Melissa Hudson video screenshot
Melissa Hudson video screenshot

It’s in the genes: research reveals obstacles on the road to health for cancer survivors

Alex Generous, PhD

St. Jude scientists are leading research into the genetics of childhood cancer survivorship to understand and prevent the risk of chronic disease in survivors.

Peter McKinnon, Kathryn Stephenson, Richard Finkel
Peter McKinnon, Kathryn Stephenson, Richard Finkel

Two Years of the Pediatric Translational Neuroscience Initiative

Alex Generous, PhD

St. Jude initiative aims to change the outlook for children with catastrophic neurological diseases.

Xu Yang and Yizhen Li in a laboratory
Xu Yang and Yizhen Li in a laboratory

T cells are key to maintaining cancer remissions from chemotherapy

Erin Podolak, MA

Stimulating the adaptive immune response can improve outcomes for ALL treated with chemotherapy.