Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

The current landscape and promising future of sickle cell disease therapy
The current landscape and promising future of sickle cell disease therapy

The current landscape and promising future of sickle cell disease therapy

Jeremie Estepp, MD

Major advancements in sickle cell disease therapy hold a promising future for patients, including organ preservation and a possible cure.

Are scientific citations meaningful? Scientific progress from a larger perspective
Are scientific citations meaningful? Scientific progress from a larger perspective

Are scientific citations meaningful? Scientific progress from a larger perspective

Lindsey Montefiori, PhD

Scientific citations identify valuable research. Here’s what it’s like to be a part of a lab ranked in the top 1% of citations.

Word to the wise: Don’t let the genomic data fool you
Word to the wise: Don’t let the genomic data fool you

Word to the wise: Don’t let the genomic data fool you

Mary Powers

In the world of genomics, this computational biologist recommends these simple things before interpreting the data.

How to calm the cytokine storm in COVID-19 and beyond
How to calm the cytokine storm in COVID-19 and beyond

How to calm the cytokine storm in COVID-19 and beyond

Rebecca Tweedell, PhD

Some COVID-19 infections can create a molecular storm inside your body that can be fatal. This research team may have found a way to stop it.

New clues about the machinery of brain development
New clues about the machinery of brain development

New clues about the machinery of brain development

David J. Solecki, PhD

The nature of brain development reveals that these two things are key – and also may hold clues to fighting childhood brain cancers.

Why do many promising experimental drugs fail? Data-driven research may hold the answer
Why do many promising experimental drugs fail? Data-driven research may hold the answer

Why do many promising experimental drugs fail? Data-driven research may hold the answer

Erin Podolak, MA

G-protein-coupled receptors are a popular target for drug therapies. This researcher is finding out why some drugs targeting GPCRs fail.

Changing the trajectory of flu for the sickest patients
Changing the trajectory of flu for the sickest patients

Changing the trajectory of flu for the sickest patients

David Boyd, PhD

Research reveals that supportive tissue in the lungs helps coordinate the immune response to flu by regulating access to the tissue and inflammation in the lungs.

It is better to be safe than fast when it comes to the development of a COVID-19 vaccine.
It is better to be safe than fast when it comes to the development of a COVID-19 vaccine.

COVID-19 vaccine development: better safe than fast

Stacey Schultz-Cherry, PhD

This is the most important thing to remember about vaccines for COVID-19 and other diseases going through clinical trials.

Can common nasal bacteria be targeted to slow flu transmission? Maybe.
Can common nasal bacteria be targeted to slow flu transmission? Maybe.

Can common nasal bacteria be targeted to slow flu transmission? Maybe.

Mary Powers

This new study shows that flu transmission and infection could be slowed or prevented by this simple technique.

T-Cell therapy may bridge treatment gap for pediatric acute myeloid leukemia
T-Cell therapy may bridge treatment gap for pediatric acute myeloid leukemia

T-Cell therapy may bridge treatment gap for pediatric acute myeloid leukemia

Paulina Velasquez, MD

This clinical trial may be the key for leukemia patients getting a curative bone marrow transplant.