St. Jude Research

Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

3 men in a lab
3 men in a lab

CRISPR kickstarts combination drug discovery for neuroblastoma

Alex Generous, PhD

A CRISPR screen reveals a potential combination therapy for relapsed neuroblastoma.

Finding the big-TIME players holding back CAR T–cell therapy for high-grade gliomas

 Alex Generous, PhD

Explore how tumor-associated macrophages shape CAR T-cell therapy efficacy in high-grade gliomas.

(L to R) First author Prahalathan Pichavaram, PhD, corresponding author Andrew Murphy, MD, St. Jude Department of Surgery and co-author Carolyn Jablonowski, PhD.
(L to R) First author Prahalathan Pichavaram, PhD, corresponding author Andrew Murphy, MD, St. Jude Department of Surgery and co-author Carolyn Jablonowski, PhD.

Ribosome production presents a new therapeutic opportunity against Wilms tumor

 Alex Generous, PhD

Discover how disruption ribosomes creation provides promise for “undruggable” cancers.

Ashraf Mohommed and Aseem Ansari
Ashraf Mohommed and Aseem Ansari

Just like the real thing: Synthetic gene expression regulators demonstrate success

 Brian O'Flynn, PhD

See how Aseem Ansari's SynGRs target BET proteins, offering potential for treating diseases like Friedreich’s ataxia and advancing BET domain understanding

Clifford Brangwynne, PhD, Princeton University
Clifford Brangwynne, PhD, Princeton University

St. Jude Research Collaboratives program reaches across institutional boundaries to multiply impact

 Jessica Gullett-Rubino, PhD

Learn more about how the St. Jude Research Collaboratives Program is driving scientific breakthroughs.

Leukemia and Down Syndrome illustration
Leukemia and Down Syndrome illustration

Consortium on leukemia in children with Down syndrome offers energy and optimism

 Brian O'Flynn, PhD

Leukemia in children with Down syndrome addressed at St. Jude as international consortium meets

Emily Zheng and Jesse Smith
Emily Zheng and Jesse Smith

Shared Resources Spotlight: Biostatistics Shared Resource

 Elizabeth Casolo

Meet the investigators in the Biostatistics Shared Resource to learn how this under-recognized field is a critical component of successful research.

Paul Taylor, et al
Paul Taylor, et al

Preventing neurodevelopmental disorders through genetic compensation

 Brian O'Flynn, PhD

See how a gene family is implicated in the cause and rescue of neurodegenerative disease

Nuclear receptor DNA
Nuclear receptor DNA

Electrical engineering sparks discovery in how human nuclear receptors bind to DNA

 Brian O'Flynn, PhD

See how nuclear receptors selectively bind to DNA.

Shondra Pruett-Miller, PhD, and Jamaica Siwak at work
Shondra Pruett-Miller, PhD, and Jamaica Siwak at work

Shared Resources Spotlight: Center for Advanced Genome Engineering

 Elizabeth Casolo

Research from the Center for Applied Genome Engineering plays a pivotal role in discovery.