Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

posterior fossa
posterior fossa

Getting to the bottom of a medulloblastoma mystery

Erin Podolak, MA

Posterior fossa syndrome develops in some children following surgery for the brain tumor medulloblastoma. St. Jude research offers fresh insight into the mysterious syndrome and advice on how to avoid it.

Leaf with water droplets
Leaf with water droplets

For the growing number of childhood cancer survivors, five-year survival is just the beginning

AnnaLynn Williams, PhD

As cancer survivorship changes, new benchmarks must be set to redefine survivorship research and treatment success.

EKG screen
EKG screen

The heart of the matter – cancer survivors and heart disease

Matthew J. Ehrhardt, MD

Cancer treatments can result in damage to the heart both during treatment and years following completion of therapy. As many cancer survivors are now living longer into adulthood, we’re gaining a better understanding of some of the late effects of cancer treatments that we weren’t able to observe before.

A 3D print of influenza virus shows the yellow surface covered with proteins called hemagglutinin (colored blue) and neuraminidase (colored red) that enable the virus to enter and infect human cells. Image provided by the National Institutes of Health.
A 3D print of influenza virus shows the yellow surface covered with proteins called hemagglutinin (colored blue) and neuraminidase (colored red) that enable the virus to enter and infect human cells. Image provided by the National Institutes of Health.

Immune markers offer clues to antibody production in response to flu

Mary Powers

Scientists are learning more about antibody production in response to flu, including how they develop from helper T cells and monocytes.

Blocking the progression of pre-leukemic disorders
Blocking the progression of pre-leukemic disorders

Blocking the progression of pre-leukemic disorders

Erin Podolak, MA

Genetic changes in the biology of blood cells can lead them down a path to cancer. This researcher is figuring out how that happens.

St. Jude mourns the death of Arthur W. Nienhuis, MD
St. Jude mourns the death of Arthur W. Nienhuis, MD

Gene therapy pioneer led St. Jude through unprecedented growth

Elizabeth Jane Walker

Leader, mentor, scientist, physician and gene therapy pioneer: Arthur Nienhuis' extensive legacy of science and medicine.

Common astrovirus can lead to serious health problems
Common astrovirus can lead to serious health problems

Common astrovirus can lead to serious health problems

Stacey Schultz-Cherry, PhD

This viral infection is so common nearly everyone has had it - and it can become deadly serious for those who have compromised immune systems.

Learning the connection between research and the people it helps
Learning the connection between research and the people it helps

Learning the connection between research and the people it helps

Chris Pennington

St. Jude highlights Regina Kolaitis, PhD, who shares the moment she learned about the connection between her research and the people it helped.

Reducing deep sequencing errors to find residual cancer cells
Reducing deep sequencing errors to find residual cancer cells

Reducing deep sequencing errors to find residual cancer cells

Xiaotu Ma, PhD

This new computational tool pinpoints errors in ultra deep sequencing to identify residual cancer cells that normal sequencing misses.

The current landscape and promising future of sickle cell disease therapy
The current landscape and promising future of sickle cell disease therapy

The current landscape and promising future of sickle cell disease therapy

Jeremie Estepp, MD

Major advancements in sickle cell disease therapy hold a promising future for patients, including organ preservation and a possible cure.