St. Jude Research

Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Optimizing leukemia treatment through pharmaceutical science
Optimizing leukemia treatment through pharmaceutical science

Optimizing leukemia treatment through pharmaceutical science

 Mary Relling, PharmD

Effective leukemia treatment is one thing – making sure it’s optimized with minimal implications is another. Read research juggles both to help patients.

Discovering how T cell 'exhaustion' is triggered could energize cancer immunotherapy
Discovering how T cell 'exhaustion' is triggered could energize cancer immunotherapy

Discovering how T cell “exhaustion” is triggered could energize cancer immunotherapy

 Ben Youngblood, PhD

Read how the discovery of this gene could change immunotherapy cancer and viral infection treatments.

Enzymes that unlock stress granules, our cells’ biological ‘storm shelters,’ open pathway to treating muscle, brain disorders
Enzymes that unlock stress granules, our cells’ biological ‘storm shelters,’ open pathway to treating muscle, brain disorders

Enzymes that unlock stress granules, our cells’ biological ‘storm shelters,’ open pathway to treating muscle, brain disorders

 Mondira Kundu, MD, PhD

Stress granules form from heat shock to the cell then disappear, but when treated with an inhibitor to the protein ULK, the stress granules persist event after removal of the stress.

Length matters in dipeptide repeat polypeptides – and can be a way to treat ALS
Length matters in dipeptide repeat polypeptides – and can be a way to treat ALS

Length matters in dipeptide repeat polypeptides – and can be a way to treat ALS

 Richard Kriwacki, PhD

Read how the length of these proteins may be an indicator of ALS.

Treatment strategies matter in childhood ALL survivorship
Treatment strategies matter in childhood ALL survivorship

Exploring survivorship: The when and how of treatment strategies matter in adult survivors of childhood ALL

 Mike O’Kelly

It used to be just about surviving–now, it’s about treating children with ALL to live long, healthy lives. Learn about ALL survivorship research from ASCO.

Researchers share real-time clinical genomics data through St. Jude Cloud platform
Researchers share real-time clinical genomics data through St. Jude Cloud platform

Researchers introduce real-time clinical genomics data using St. Jude Cloud platform at 2019 ASCO annual meeting

 Elizabeth Whittington

Scott Newman, PhD, shares the release of real-time clinical genomics data through the St. Jude Cloud platform at the 2019 American Society of Clinical Oncology (ASCO) meeting in Chicago, Illinois.

Researchers develop method to dramatically reduce error rate in next-generation sequencing
Researchers develop method to dramatically reduce error rate in next-generation sequencing

Researchers develop method to dramatically reduce error rate in next-generation sequencing

 St. Jude Communications Department

It’s easier to find a needle in a haystack when you take away the hay – read how this research team is reducing gene sequencing errors.

Genetic variations in a fourth gene linked to elevated leukemia risk in Hispanic children
Genetic variations in a fourth gene linked to elevated leukemia risk in Hispanic children

Genetic variations in a fourth gene linked to elevated leukemia risk in Hispanic children

 Jun Yang, PhD

Read how ancestry plays a role in determining your risk for cancer. In the case of Hispanic children, researchers found an increased risk of leukemia.

Gene therapy: Scientific breakthrough and a legacy of a cure
Gene therapy: Scientific breakthrough and a legacy of a cure

Gene therapy: Scientific breakthrough and a legacy of a cure

 James R. Downing, MD

Read about the work from a goal – to a treatment – to a cure – and one scientist’s legacy.

Pediatric melanoma mystery solved by genome sequencing research
Pediatric melanoma mystery solved by genome sequencing research

Pediatric melanoma mystery solved by genome sequencing research

 Scott Newman, PhD

Two pediatric melanoma cases diagnosed a year apart reveal a new genetic driver of the disease. Read more about this spitzoid melanoma work.