Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Pediatric melanoma mystery solved by genome sequencing research
Pediatric melanoma mystery solved by genome sequencing research

Pediatric melanoma mystery solved by genome sequencing research

Scott Newman, PhD

Two pediatric melanoma cases diagnosed a year apart reveal a new genetic driver of the disease. Read more about this spitzoid melanoma work.

Bioinformatics research scientist helps unlock elusive data
Bioinformatics research scientist helps unlock elusive data

From evolutionary biology to immunology via bioinformatics

Gary Bridgman

Immunologists turn to Jeremy Crawford, PhD, when planning complex experiments or re-analyzing collected data. Learn about his bioinformatics career.

Researchers identify new necroptosis triggers
Researchers identify new necroptosis triggers

Researchers identify new molecular triggers for cell’s 'executioner'

Chris Pennington

Read how this molecule rips the “skin” of the cell to kill it, and how research is learning how this power is unleased.

What hidden hazards lie beneath the surface of genome editing?
What hidden hazards lie beneath the surface of genome editing?

What hidden hazards lie beneath the surface of genome editing?

Keith Crabtree, PhD

Are you sure? Understanding the possible traps and dangers with gene editing.

Commitment to excellence: Building a world-class Structural Biology Department at St. Jude
Commitment to excellence: Building a world-class Structural Biology Department at St. Jude

Commitment to excellence: Building a world-class Structural Biology Department at St. Jude

Charalampos Kalodimos, PhD

Read how this rapidly evolving area of science seeks to change the way we look at the world.

Cell Seek provides a path to understanding the cellular origins of brain tumors
Cell Seek provides a path to understanding the cellular origins of brain tumors

Cell Seek provides a path to understanding the cellular origins of pediatric brain tumors

Lee Morgan

What if scientists shared data about brain development to find the origins of brain tumors and disorders? These scientists did, and it changed everything.

10,000 reasons St. Jude Cloud can help advance science

Chris Pennington

10,000 reasons St. Jude Cloud can help advance science

Medulloblastoma therapy may get better thanks to key technology
Medulloblastoma therapy may get better thanks to key technology

Medulloblastoma therapy may get better thanks to ‘key’ technology

Martine F. Roussel, PhD

In testing a new treatment for a deadly brain tumor, read what these researchers did to figure out how to make exact duplicates of the cancer.

Innate immunity: the body’s first line of defense against a dangerous fungus
Innate immunity: the body’s first line of defense against a dangerous fungus

Innate immunity: the body’s first line of defense against a dangerous fungus

Thirumala-Devi Kanneganti, PhD

Innate immunity is your body’s first line of defense. What happens when it’s weakened? Researchers are using this common fungus to find out how to help.

Medulloblastoma and microirradiation: Tiny treatments for the most common malignant pediatric brain tumor
Medulloblastoma and microirradiation: Tiny treatments for the most common malignant pediatric brain tumor

Medulloblastoma and microirradiation: Tiny treatments for the most common malignant pediatric brain tumor

Martine F. Roussel, PhD

Medulloblastoma may soon be treated by a microirradiator - a machine the size of two refrigerators that beams radiation down to half the width of a credit card.