Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

New CAR T-Cell therapy for pediatric ALL approved, more to come
New CAR T-Cell therapy for pediatric ALL approved, more to come

New CAR T-Cell therapy for pediatric ALL approved, more to come

Stephen Gottschalk, MD

The FDA has approved Kymriah, the first CAR T-cell therapy for acute lymphoblastic leukemia. Find out how St. Jude is planning to use this novel treatment.

Can ESCRT-III proteins protect cells from necroptosis?
Can ESCRT-III proteins protect cells from necroptosis?

Cell necroptosis: Can ESCRT-III proteins protect cells from the kill switch?

Douglas R. Green, PhD

Find out how a newly discovered protein can give your body’s doomed cells a second chance at life.

Epigenetic mapping leads to developmental insights into retinoblastoma
Epigenetic mapping leads to developmental insights into retinoblastoma

Cracking the epigenetic code of retinoblastoma

Michael Dyer, PhD

St. Jude scientists, in work published in the journal Neuron, used powerful analytical tools to map what is known as the “epigenetics” of the retina.

Uncovering the body’s immune system response
Uncovering the body’s immune system response

Discovering new molecular switches to control autoinflammatory disease

Thirumala-Devi Kanneganti, PhD

Is Ptpn6, a controlling gene, linked with the master immune switch IL-1 alpha? Can this link be mapped to help pinpoint immune system response? Find out more.

NIH grant-funding seminar highlights rigor, reproducibility and resources
NIH grant-funding seminar highlights rigor, reproducibility and resources

Rigor, reproducibility and resources take center stage

Clay Christian, PhD

NIH seminar elucidates new guidelines for grant-funded research as well as allocation of monies to more labs.

CCSS Offers GWAS Opportunities for Researchers
CCSS Offers GWAS Opportunities for Researchers

Childhood cancer survivorship gains offers GWAS opportunities for researchers

Greg Armstrong, MD, MSCE

Find out how to access GWAS data from the Childhood Cancer Survivor Study, to help answer how genetics.

Creating perfect blood stem cells to treat blood disorders
Creating perfect blood stem cells to treat blood disorders

Zebrafish teach us how to make blood stem cells

Wilson Clements, PhD

Zebrafish and humans are surprisingly alike when it comes to blood stem cells. Find out how studying zebrafish led to advancements in treating blood disorders.

AACR, St. Jude highlight collaboration and resources for pediatric cancer researchers
AACR, St. Jude highlight collaboration and resources for pediatric cancer researchers

AACR, St. Jude highlight collaboration and resources for pediatric cancer researchers

Michael Dyer, PhD

Learn how AACR and St. Jude offer opportunities for pediatric cancer researchers to collaborate and share resources.

Medulloblastoma Study Reveals Warning for Ezh2 Inhibitor - St. Jude Progress Blog
Medulloblastoma Study Reveals Warning for Ezh2 Inhibitor - St. Jude Progress Blog

Status update for a nasty oncogene: It’s complicated

Carole Weaver Clements, PhD

Recent research uncovers new information regarding the role Ezh2 plays in medulloblastoma development. Learn more about the study results.

Why does the risk of pediatric leukemia relapse vary by race? - St. Jude Progress Blog
Why does the risk of pediatric leukemia relapse vary by race? - St. Jude Progress Blog

Why does the risk of pediatric acute lymphoblastic leukemia relapse vary by race?

Mary Powers

These inherited gene variations may help explain why the risk of relapse for children with acute lymphoblastic leukemia varies by race.