Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Apoptosis-causing protein is an intracellular lone wolf
Apoptosis-causing protein is an intracellular lone wolf

Cancer-fighting ninja protein may offer clue to create self-harming cancer cells

Tudor Moldoveanu, PhD

This shape-shifting cipher of the cell may hold the key to curing cancer through causing cancer cells to kill themselves.

Influenza virus: Will Mother Nature deal us a deadly hand?
Influenza virus: Will Mother Nature deal us a deadly hand?

Will Mother Nature deal a deadly hand with influenza virus?

Robert Webster, PhD

How close are we to another deadly influenza virus pandemic? Read about how scientists are figuring out how to prevent the next catastrophe.

LOXO-101 effective against tumors with rare NTRK gene fusion
LOXO-101 effective against tumors with rare NTRK gene fusion

Targeted therapy larotrectinib could make tumors with rare NTRK fusion genes less lethal

Alberto Pappo, MD

Newly approved Vitrakvi (larotrectinib) scored high patient response rates by inhibiting a rare chromosomal abnormality that drives tumor growth.

Taking STEPS to improve genome-wide association studies
Taking STEPS to improve genome-wide association studies

What is extreme phenotype sequencing? Taking STEPS to improve genome-wide association studies

Guolian Kang, PhD

Will a new genome sequencing data mining technique reveal the mother lode of secrets for treating cancer and other catastrophic diseases?

What is causing resistance to the new flu drug, Xofluza?
What is causing resistance to the new flu drug, Xofluza?

What is causing resistance to the new flu drug, Xofluza?

Lee Morgan

A recently discovered mutation that occurs when the flu virus is exposed Xofluza could also cause drug resistance.

NLRP3 balance: St. Jude researchers pinpoint key regulator of innate immune system
NLRP3 balance: St. Jude researchers pinpoint key regulator of innate immune system

NLRP3 balance: St. Jude researchers pinpoint key innate immune system regulator

Thirumala-Devi Kanneganti, PhD

For 12 years, science didn’t know how certain immune responses were activated. They do now, and it may lead to new cancer treatments.

Whole genome sequencing beneficial in clinical decision-making: G4K Study
Whole genome sequencing beneficial in clinical decision-making: G4K Study

What you’re missing if you’re only sequencing exomes or RNA

Carole Weaver Clements, PhD

New findings from St. Jude study Genomes 4 Kids suggest many actionable mutations are missed without a three-platform genomic sequencing approach that includes WGS.

mTORC1, the ‘Sorting Hat’ of the thymic school
mTORC1, the ‘Sorting Hat’ of the thymic school

mTORC1, the ‘Sorting Hat’ of the thymic school

Daniel Bastardo-Blanco

House of blood or house of guts? Read how this internal Sorting Hat decides where cells go.

The SILver Lining: The yin-yang balance of proteins in Marinesco-Sjögren syndrome
The SILver Lining: The yin-yang balance of proteins in Marinesco-Sjögren syndrome

The SILver Lining: The yin-yang balance of proteins in muscle disease

Viraj Ichhaporia

Ever heard of Marinesco-Sjögren syndrome? A St. Jude lab found the mutation that causes it.

New studies raise concerns with CRISPR-Cas9, but there's more to the story
New studies raise concerns with CRISPR-Cas9, but there's more to the story

New studies raise warnings with CRISPR-Cas9, but there's more to the story

Shondra Pruett-Miller, PhD

Recent studies highlight efficacy and safety issues of CRISPR. While the results are important, read why we should wait before drawing conclusions.