Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

A hypothesis can’t be right unless it can be proven wrong
A hypothesis can’t be right unless it can be proven wrong

A hypothesis can’t be right unless it can be proven wrong

Charles Rock, PhD

Always being right is wrong — Learn how science can be corrupted by poor experiments and theories that cannot be disproven.

Sonic Hedgehog pathway – how embryonic cells broadcast growth instructions
Sonic Hedgehog pathway – how embryonic cells broadcast growth instructions

Exploring the Sonic Hedgehog pathway – how embryonic cells broadcast their growth instructions

Stacey Ogden, PhD

New research of the Sonic Hedgehog pathway shows potential targets for cancer treatments. Read how this cellular pathway plays a critical role in normal and cancerous development.

Genetic testing in childhood cancer: a Pediatric Cancer Genome Project update
Genetic testing in childhood cancer: a Pediatric Cancer Genome Project update

Genetic testing in childhood cancer: a Pediatric Cancer Genome Project update

James R. Downing, MD

Germline mutations can contribute to leukemia, retinoblastoma, and other pediatric cancers. Learn about advancements in the first landmark effort specifically designed to better understand these mutations and develop novel treatment methods.

There are thousands of whole genome sequences in St. Jude Cloud. And you can use them.
There are thousands of whole genome sequences in St. Jude Cloud. And you can use them.

There are thousands of whole genome sequences in St. Jude Cloud. And you can use them.

Carole Weaver Clements, PhD

Because of St. Jude Cloud, terabytes of pediatric cancer genomic data can now be readily accessed, analyzed and visualized.

Biostatistical model resolves questions on antibiotic side effects
Biostatistical model resolves questions on antibiotic side effects

Safety in numbers: Advanced biostatistical model resolves questions on vancomycin side effects

Josh Wolf, PhD, MBBS

Dr. Josh Wolf explains how biostatistics resolved safety questions on preemptive vancomycin for acute myeloid leukemia patients after chemotherapy.

A vaccine to prevent cancer? It’s already here.
A vaccine to prevent cancer? It’s already here.

A vaccine to prevent cancer? It’s already here.

Ellis J. Neufeld, MD, PhD

Many adolescents fail to get a key vaccination that can prevent cancer. Learn what doctors know about the HPV cancer vaccine.

Five ways to take confirmation bias out of your experimental results
Five ways to take confirmation bias out of your experimental results

Five ways to take confirmation bias out of your experimental results

Charles Rock, PhD

The most important part of research is that you must not fool yourself — and you’re the easiest person to fool.

Heme synthesis linked with acute myeloid leukemia
Heme synthesis linked with acute myeloid leukemia

Blood's oxygen transporter revealed as power source for aggressive pediatric cancer

John Schuetz, PhD

Read how the oncogene MYCN hijacks an oxygen-carrying component of hemoglobin to feed and grow aggressive AML in children.

ASH 2017: Preliminary results show gene therapy gains in X-linked SCID
ASH 2017: Preliminary results show gene therapy gains in X-linked SCID

ASH 2017: Preliminary results show gene therapy gains in SCID

Ewelina Mamcarz, MD

Gene therapy for X-linked SCID resulted in the development of T cell, B cell and natural killer cells without side effects. Read more about the research.

ASH 2017: The role of GATA3 in Ph-like acute lymphoblastic leukemia
ASH 2017: The role of GATA3 in Ph-like acute lymphoblastic leukemia

ASH 2017: GATA3 in Ph-like acute lymphoblastic leukemia

Jun Yang, PhD

Jun J. Yang, PhD, shares research presented at ASH that highlights the role the GATA3 oncogene plays in a high-risk subset of acute lymphoblastic leukemia.