St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
Full title:
Web-based Physical Activity Intervention among Children and Adolescents with Cancer
Study goal:
To evaluate the effects of an interactive, web-based exercise intervention on fitness among children and adolescents who have completed treatment for cancer.
Diagnosis:
Age:
At least 8 years old and younger than 16 years old
Full title:
Phase II Study of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma
Study goal:
The main purpose of this study is to find out what happens, good and bad, to memory and learning when the hippocampus is avoided during proton therapy radiation.
Diagnosis:
Age:
At least 6 years old and younger than 22
Clinical trial categories:
Childhood Cancer Astrocytoma Glioma Ganglioglioma Low-Grade Glioma Optic Pathway Tumor Brain TumorsFull title:
A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Patients with Advanced Solid or Primary Central Nervous System Tumors
Study goal:
The main goal of this study is to test the safety of selpercatinib in children and adolescents with solid tumors or brain and spinal cord tumors. Researchers also want to learn how the drug affects cancer in children and the best, most effective dose.
Diagnosis:
Age:
6 months to 21 years old
Full title:
Locoregional Delivery of B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cells for Pediatric Patients with Primary CNS Tumors
Study goal:
The purpose of this study is to find: 1) the largest dose of Loc3CAR T cells that is safe to give patients with B7-H3–positive brain tumors; 2) the side effects of Loc3CAR T cells; 3) the effect Loc3CAR T cells have on brain tumors. This trial will help scientists better understand how the immune system fights this kind of tumor. What we learn from this study could help us create better treatments.
Diagnosis:
Age:
Up to 21 years old
Full title:
A Safety and Preliminary Efficacy Trial of MK-3475 (Pembrolizumab; anti PD-1) in Children with Recurrent, Progressive or Refractory High-Grade Gliomas (HGG), DIPGs and Hypermutated Brain Tumors
Study goal:
To study the side effects and best dose of MK-3475 (pembrolizumab) and to see how well it works in treating younger patients with high-grade gliomas (brain tumors), diffuse intrinsic pontine gliomas (brain stem tumors), or hypermutated brain tumors that have come back, progressed or have not responded to previous treatment
Diagnosis:
Recurrent, progressive, or refractory high-grade gliomas
Age:
Participant is 1 to 18 years of age
Clinical trial categories:
Diffuse Intrinsic Pontine Glioma (DIPG) High-Grade Glioma Childhood Cancer Brain Tumors Solid TumorsFull title:
Feasibility Trial of Optune for Children with Recurrent or Progressive Supratentorial High-Grade Glioma and Ependymoma
Study goal:
The main purpose of this study is to see if the Optune System is safe to use in children. Researchers also want to find out if children are able to wear the device as instructed.
Diagnosis:
High-grade glioma (HGG), ependymoma
Age:
Between 5 and 21 years old
Full title:
Phase I study of Savolitinib in Recurrent, Progressive or Refractory Medulloblastoma, High-Grade Glioma, or Diffuse Intrinsic Pontine Glioma
Study goal:
To see if savolitinib is safe and tolerable in children with brain tumors
Diagnosis:
Medulloblastoma, high-grade glioma (HGG), diffuse intrinsic pontine glioma (DIPG)
Age:
Between 5 years old and 21 years old
Clinical trial categories:
Childhood Cancer Diffuse Intrinsic Pontine Glioma (DIPG) Medulloblastoma High-Grade Glioma Brain TumorsFull title:
A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection
Study goal:
The main goal of this study is to learn if proton therapy will treat patients with craniopharyngioma brain tumors effectively and reduce side effects compared to traditional forms of radiation therapy.
Diagnosis:
Age:
21 years old or younger
Full title:
SJ901: Phase 1/2 Evaluation of Single Agent Mirdametinib (PD-0325901), a Brain-Penetrant MEK1/2 Inhibitor, for the Treatment of Children, Adolescents, and Young Adults With Low-Grade Glioma
Study goal:
The main goal of this study is to test the experimental drug mirdametinib in hopes of finding a treatment that may be effective against low-grade glioma brain tumors in children, adolescents and young adults.
Diagnosis:
Age:
At least 2 years old and younger than 25 years old.
Full title:
SJLIFE: Establishment of a Lifetime Cohort of Adults Surviving Childhood Cancer
Study goal:
To establish a lifetime group of childhood cancer survivors treated at St. Jude Children’s Research Hospital and to evaluate health outcomes in aging survivors of pediatric cancer
Age:
Participants must be at least 5 years from diagnosis of childhood cancer between 1962-2012, treated and followed at St. Jude
Full title:
SJLTFU: Protocol for Collecting Data on Childhood Cancer Survivors
Study goal:
To collect information about the effects of childhood cancer and its treatment on the patients who are treated or followed after treatment for childhood cancer at St. Jude Children’s Research Hospital
Full title:
Estimating Setup Uncertainty in Pediatric Proton Therapy Using Volumetric Images
Study goal:
The main goal of this study is to collect information about how a patient is positioned and set up for radiation therapy.
Diagnosis:
Full title:
SJiMB21: Phase 2 Study of Molecular and Clinical Risk-Directed Therapy for Infants and Young Children with Newly Diagnosed Medulloblastoma
Study goal:
This study uses a risk-directed approach to find out which types of treatment will work best and have the fewest side effects for infants and children with medulloblastoma.
Diagnosis:
Age:
Birth to 5 years old
Full title:
Components of Social Functioning in Survivors of Pediatric Brain Tumors
Study goal:
Examine the impact of social-cognitive and neurocognitive abilities on social functioning in survivors of pediatric brain tumors
Diagnosis:
Full title:
Understanding Communication in Health Care to Achieve Trust: A Prospective Longitudinal Investigation of Communication between Pediatric Oncologists, Children/Adolescents with High-Risk Cancer, and their Families at the Stressful Times of Disease Relapse or Progression
Study goal:
To identify recurrent verbal and nonverbal communication techniques employed by pediatric oncologists in the delivery of difficult prognostic information to parents through content analysis of audio recorded conversations between pediatric oncologists and parents of children with high-risk cancer at times of disease re-evaluation
Diagnosis:
Non-therapeutic
Age:
Patients: Age 30 or younger
Parents: Age 18 or older