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St. Jude is developing one of the largest immunotherapy research programs in the United States. At the Center of Excellence for Pediatric Immuno-Oncology, our scientists and doctors work to expand and improve immunotherapies for childhood cancers.
Immunotherapy uses the immune system to treat diseases such as cancer. The immune system includes special white blood cells, tissues, and organs that work together to prevent and get rid of disease.
Immunotherapy is a type of biological therapy that uses the immune system to find and remove unhealthy or damaged cells, including cancer cells. Your child’s health care team may combine immunotherapy with treatments such as chemotherapy and bone marrow transplant to kill cancer more effectively.
Immunotherapy at St. Jude Children’s Research Hospital comes in different forms and works in separate ways. Some kinds of immunotherapy make the overall immune system stronger. Other types of immunotherapies make a person’s immune system work better against a specific disease.
St. Jude is developing one of the largest immunotherapy research programs in the United States. At the Center of Excellence for Pediatric Immuno-Oncology, our scientists and doctors work to expand and improve immunotherapies for childhood cancers. They develop treatments for some of the toughest childhood diseases, including brain and solid tumors.
Immunotherapy includes treatments such as:
CAR T-cell therapies target a specific molecule on the surface of a cancer cell. CAR T-cell therapy got its start in a St. Jude lab many years ago. It has changed treatment for patients with certain types of advanced leukemia and lymphoma.
Immunotherapies treat several childhood cancers, including:
Study goal:
The purpose of this study is to find: 1) the largest dose of Loc3CAR T cells that is safe to give patients with B7-H3–positive brain tumors; 2) the side effects of Loc3CAR T cells; 3) the effect Loc3CAR T cells have on brain tumors. This trial will help scientists better understand how the immune system fights this kind of tumor. What we learn from this study could help us create better treatments.
Diagnosis:
Age:
Up to 21 years old
Study goal:
In Part 1 of this study, we will see if sorafenib, cyclophosphamide, bevacizumab, and atezolizumab can be given safely together without causing serious side effects. Part 2 of the study will find out how well these medicines work in hepatocellular carcinoma, fibrolamellar carcinoma, desmoplastic small round cell tumors, and malignant rhabdoid tumors.
Diagnosis:
Solid tumors, hepatocellular carcinoma, fibrolamellar hepatocellular carcinoma, sarcomas, malignant rhabdoid tumors, desmoplastic small round cell tumors
Age:
1-30 years old
Study goal:
The main purpose of 3CAR is to find out if this type of immunotherapy is safe for pediatric patients with solid tumors. We also want to learn if it is effective in fighting solid tumors.
Diagnosis:
Age:
Up to 21 years old
Study goal:
The main purpose of this study is to find out the good and bad effects of eflornithine combined with irinotecan, temozolomide, and dinutuximab in children and young adults with relapsed or refractory neuroblastoma.
Diagnosis:
Age:
At least 1 year old
Study goal:
The main purpose of this study is to find the highest dose of CD123-CAR T cells that is safe to give patients with AML. We also want to study the side effects of the treatment and learn how effective it is in fighting this type of cancer.
Diagnosis:
Age:
21 years old or younger
Study goal:
To study the side effects and best dose of MK-3475 (pembrolizumab) and to see how well it works in treating younger patients with high-grade gliomas (brain tumors), diffuse intrinsic pontine gliomas (brain stem tumors), or hypermutated brain tumors that have come back, progressed or have not responded to previous treatment
Diagnosis:
Recurrent, progressive, or refractory high-grade gliomas
Age:
Participant is 1 to 18 years of age
Study goal:
The main goal of this study is to learn the largest dose of memory CAR T cells that can be safely given. Researchers also want to learn about the way memory CAR T cells act in the body and how effectively they treat this type of cancer.
Diagnosis:
Age:
Donor: At least 19 years old; Recipient: 21 years or younger
Study goal:
The purpose of this study is to find the highest dose of CD70+ CAR cells that is safe to give to patients with CD70+ blood cancers.
Age:
Up to 21 years old
Our immunotherapy team is a close-knit group of doctors who work with a specially trained health care team. This team includes nurses, medical specialists, and staff from clinical nutrition, social work, pharmacy, and child life.
The health care team will review your child’s immunotherapy treatment plan, including the schedule and dose. The details will depend on the type of immunotherapy your child is scheduled to receive.
For example:
Whatever your child’s treatment, you will have time to ask your health care teams questions and to discuss any concerns.
Immunotherapy side effects are different based on your child’s treatment. Your child’s health care team will tell you what to expect and how to respond. They will also answer questions and talk about your concerns.