About this study
New treatments are needed to help children and young adults whose brain cancers return or are hard to treat. CAR T–cell therapy is a type of immunotherapy where the body’s T cells are changed in the lab so that they can attack cancer cells. Loc3CAR is a study that uses CAR T cells to treat children and young adults with brain tumors that have returned or are hard to treat. The changed T cells (Loc3CAR) recognize a protein called B7-H3, found in many childhood brain tumors.
In this study, we will collect white blood cells (T cells) from the patient. We will change those cells in the lab to make the Loc3CAR cells. The Loc3CAR cells are returned to the patient so they can attack the tumors with a specific type of protein called B7-H3. The Loc3CAR cells are given using a small, flexible tube (catheter) that enters the brain and delivers the cells. An IV is not used.
Eligibility overview
To take part in this study, you must:
- Have a tumor that is positive for B7-H3
- Be 21 years old or younger
- Patients must stay in Memphis while getting CAR T-cells.