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HAP2HCT: Partially Matched Family Donor Bone Marrow Transplant in Children and Young Adults with High Risk Cancer

About this study

This clinical trial will test a type of hematopoietic (blood-making) cell transplant in children and young adults with certain high-risk cancers that are hard to treat. A hematopoietic cell transplant is also known as a bone marrow transplant or stem cell transplant.

This type of transplant replaces damaged or destroyed blood and bone marrow cells with healthy ones from another person. The person who gives you the healthy cells is called a donor.

When patients require a bone marrow transplant, the first type of donor to be considered is a matched sibling (brother or sister) donor. For patients who have no matched siblings, a matched unrelated volunteer donor is looked at next. If you have no matched unrelated donor, or if the donor is not available, a partially matched family member donor, such as a parent, sibling, aunt or uncle may be considered.

This study is for patients who do not have a suitable donor match. In this clinical trial, your donor will be a partially matched family member.

Eligibility overview

For transplant recipient:

  • 21 years or younger
  • Does not have a suitable sibling donor or volunteer unrelated donor
  • Has a suitable single haplotype matched family member donor
  • Diagnosed with high risk hematologic malignancy
  • No prior allogeneic stem cell transplant

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

TCRαβ-depleted Progenitor Cell Graft with Additional Memory T-Cell DLI, plus Selected Use of Blinatumomab, in Naïve T-Cell depleted Haploidentical Donor Hematopoietic Cell Transplantation for Hematologic Malignancies

Study goal:

The main goal of this study is to learn more about new methods of transplanting blood cells donated by a family member. Researchers will look at how chemotherapy, the transplant cell product and the additional white blood cell infusion affect your body, disease and overall survival.

Diagnosis:

Acute lymphoblastoma, acute myeloid leukemia, myelodysplasia, Hodgkin lymphoma, Non-Hodgkin lymphoma, juvenile myelomonocytic leukemia

Age:

21 years or younger

Clinical trials categories:

Hodgkin Lymphoma Juvenile Myelomonocytic Leukemia Acute Myeloid Leukemia (AML) Childhood Cancer Lymphoma Leukemia Myelodysplastic Syndromes Non-Hodgkin Lymphoma Acute Lymphoblastic Leukemia (ALL)

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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