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AT1026: Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

About this study

Studies have shown that women and men differ in how their bodies metabolize certain drugs. Pregnancy may have an additional effect on drug metabolism for women. Pregnant women experience unique physiological changes that may result in clinically significant changes in drug pharmacokinetics (the way the body uses the drug) and pharmacodynamics (how the drug acts on the body).

This study will evaluate the pharmacokinetics and pharmacodynamics of currently prescribed antiretroviral drugs and interacting combinations of these drugs in pregnant HIV-infected women.

Objectives

  • Evaluate the pharmacokinetics and pharmacodynamics of selected antiretroviral drugs currently used in therapy of pregnant HIV-infected women
    Compare antiretroviral drug levels in blood from the mother and her baby at time of birth

Eligibility overview

The subject has been enrolled on IMPAACT P1025.

This is a non-therapeutic clinical trial that is ony open to St. Jude patients.

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

PACTG1026S-Pharmacokinetic Properties of Antiretroviral Drugs During Pregnancy

Study goal:

This study will evaluate the pharmacokinetics and pharmacodynamics of currently prescribed antiretroviral drugs and interacting combinations of these drugs in pregnant HIV-infected women.

Diagnosis:

HIV Infection

Clinical trials categories:

Human Immunodeficiency Virus (HIV) Infection Infectious Diseases

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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