Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Learn the basics of CAR T-cell immunotherapy and how it is being used in the SJCAR19 clinical trial for acute lymphoblastic leukemia
Learn the basics of CAR T-cell immunotherapy and how it is being used in the SJCAR19 clinical trial for acute lymphoblastic leukemia

Learn the basics of CAR T-cell therapy and how it is being used in the SJCAR19 clinical trial at St. Jude

Aimee Talleur, MD

Learn the basics of CAR T-cell immunotherapy and how it is being used in the SJCAR19 clinical trial for acute lymphoblastic leukemia.

A moving target: Taking aim at the shift and drift of influenza viruses
A moving target: Taking aim at the shift and drift of influenza viruses

A moving target: Taking aim at the shift and drift of influenza viruses

Daniel Darnell

How close are we to a flu pandemic? Read how it could happen and what researchers are doing to prevent it.

Blazing through new territory to fight a devastating neurodegenerative disease
Blazing through new territory to fight a devastating neurodegenerative disease

Blazing through new territory to fight a devastating neurodegenerative disease

St. Jude Communications Department

Read how researchers have found a path to control coenzyme A and possibly prevent a devastating neurodegenerative disease.

Does obesity give influenza more time to spread and impair flu vaccines?
Does obesity give influenza more time to spread and impair flu vaccines?

Can obesity give influenza more time to spread and make vaccines less effective?

Stacey Schultz-Cherry, PhD

St. Jude researchers, led by Dr. Stacey Schultz-Cherry, are asking questions about potential association between flu severity and the obesity epidemic.

Gut microbiome predicts infection risk in leukemia patients
Gut microbiome predicts infection risk in leukemia patients

Gut microbiome sequencing opens new possibilities for predicting infection in leukemia patients

St. Jude Communications Department

Researchers identify intestinal microbiota that may predict infection risk during chemotherapy in pediatric ALL patients. Learn about the gut microbiome.

New drug for a rare disorder: How will Gamifant’s approval affect HLH treatment?
New drug for a rare disorder: How will Gamifant’s approval affect HLH treatment?

New drug for a rare disorder: How will Gamifant’s approval affect HLH treatment?

Melissa Hines, MD

HLH, a rare disorder of the immune system, is caused by a buildup of proteins responding to infection. Read about a new treatment that limits that buildup.

Tumor microenvironment goes from homely to hostile when LAP is turned off
Tumor microenvironment goes from homely to hostile when LAP is turned off

Tumor microenvironment switches from homely to hostile when this process is turned off

Douglas R. Green, PhD

Researchers learn how this housekeeper for cancer cells turns into a cancer house killer. Learn how targeting LAP could promote an anti-tumor response and slow tumor growth.

New algorithm could help us better understand cancer at its genetic level
New algorithm could help us better understand cancer at its genetic level

New algorithm could help us better understand cancer at its genetic level

Xiang Chen, PhD

This new cancer algorithm shows possible precision options for cancer treatment.

Apoptosis-causing protein is an intracellular lone wolf
Apoptosis-causing protein is an intracellular lone wolf

Cancer-fighting ninja protein may offer clue to create self-harming cancer cells

Tudor Moldoveanu, PhD

This shape-shifting cipher of the cell may hold the key to curing cancer through causing cancer cells to kill themselves.

Influenza virus: Will Mother Nature deal us a deadly hand?
Influenza virus: Will Mother Nature deal us a deadly hand?

Will Mother Nature deal a deadly hand with influenza virus?

Robert Webster, PhD

How close are we to another deadly influenza virus pandemic? Read about how scientists are figuring out how to prevent the next catastrophe.