St. Jude Research

Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

LOXO-101 effective against tumors with rare NTRK gene fusion
LOXO-101 effective against tumors with rare NTRK gene fusion

Targeted therapy larotrectinib could make tumors with rare NTRK fusion genes less lethal

 Alberto Pappo, MD

Newly approved Vitrakvi (larotrectinib) scored high patient response rates by inhibiting a rare chromosomal abnormality that drives tumor growth.

Taking STEPS to improve genome-wide association studies
Taking STEPS to improve genome-wide association studies

What is extreme phenotype sequencing? Taking STEPS to improve genome-wide association studies

 Guolian Kang, PhD

Will a new genome sequencing data mining technique reveal the mother lode of secrets for treating cancer and other catastrophic diseases?

What is causing resistance to the new flu drug, Xofluza?
What is causing resistance to the new flu drug, Xofluza?

What is causing resistance to the new flu drug, Xofluza?

 Lee Morgan

A recently discovered mutation that occurs when the flu virus is exposed Xofluza could also cause drug resistance.

NLRP3 balance: St. Jude researchers pinpoint key regulator of innate immune system
NLRP3 balance: St. Jude researchers pinpoint key regulator of innate immune system

NLRP3 balance: St. Jude researchers pinpoint key innate immune system regulator

 Thirumala-Devi Kanneganti, PhD

For 12 years, science didn’t know how certain immune responses were activated. They do now, and it may lead to new cancer treatments.

Whole genome sequencing beneficial in clinical decision-making: G4K Study
Whole genome sequencing beneficial in clinical decision-making: G4K Study

What you’re missing if you’re only sequencing exomes or RNA

 Carole Weaver Clements, PhD

New findings from St. Jude study Genomes 4 Kids suggest many actionable mutations are missed without a three-platform genomic sequencing approach that includes WGS.

mTORC1, the ‘Sorting Hat’ of the thymic school
mTORC1, the ‘Sorting Hat’ of the thymic school

mTORC1, the ‘Sorting Hat’ of the thymic school

 Daniel Bastardo-Blanco

House of blood or house of guts? Read how this internal Sorting Hat decides where cells go.

The SILver Lining: The yin-yang balance of proteins in Marinesco-Sjögren syndrome
The SILver Lining: The yin-yang balance of proteins in Marinesco-Sjögren syndrome

The SILver Lining: The yin-yang balance of proteins in muscle disease

 Viraj Ichhaporia

Ever heard of Marinesco-Sjögren syndrome? A St. Jude lab found the mutation that causes it.

New studies raise concerns with CRISPR-Cas9, but there's more to the story
New studies raise concerns with CRISPR-Cas9, but there's more to the story

New studies raise warnings with CRISPR-Cas9, but there's more to the story

 Shondra Pruett-Miller, PhD

Recent studies highlight efficacy and safety issues of CRISPR. While the results are important, read why we should wait before drawing conclusions.

59,000 Volunteers and a team of scientists uncover inherited gene mutations for medulloblastoma
59,000 Volunteers and a team of scientists uncover inherited gene mutations for medulloblastoma

All in the family: How 59,000 volunteers and a team of scientists helped uncover six inherited gene mutations for medulloblastoma

 Paul Northcott, PhD

There were 110 suspect genes. We found the six that could lead to childhood brain tumors.

New discoveries are simply that and must withstand the test of time
New discoveries are simply that and must withstand the test of time

New discoveries are simply that and must withstand the test of time

 Charles Rock, PhD

You really trust the ‘latest and greatest?’ Over-hyped scientific discoveries that haven’t been thoroughly tested create false hope for cures.