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RBAPP: Smartphone App for Retinoblastoma

About this study

Leukocoria is an eye condition that affects some children. Leukocoria means “white pupil.” It is the most common warning sign of retinoblastoma, a rare and serious childhood cancer of the eye. It can also be a sign of other diseases, including cataracts, glaucoma, retinal detachments and eye infections.

Currently, pediatricians and other doctors use a special tool to screen for leukocoria. This tool is called an ophthalmoscope. It allows the doctor to inspect the retina and other parts of the eye. Unfortunately, not all doctors perform this screening regularly. Even when they do screen, the ophthalmoscope may not detect retinoblastoma tumors in the eye.

In this study, researchers want to find out if a new method called CRADLE (ComputeR Assisted Detection of LEukocoria) will be better than the ophthalmoscope method at detecting leukocoria. CRADLE is a camera phone application that can be downloaded onto any smartphone device.

Purpose of this clinical trial

The main purpose of this study is to find out the best way to use the CRADLE app to identify leukocoria in children with retinoblastoma, congenital cataracts and glaucoma. Researchers hope to learn information that could help improve screening in the future, leading to earlier diagnosis of these conditions.

Eligibility overview

  • 7 years old or younger
  • Part I
    • Diagnosed with retinoblastoma and has not received any treatment OR
    • Diagnosed with cataracts and has not received any treatment OR
    • Diagnosed with glaucoma and has not received any treatment
  • Part II
    • Referred to an eye doctor to check for leukocoria or other eye conditions
  • Part III
    • Diagnosed with retinoblastoma and is receiving treatment

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

Determination of the Sensitivity and Specificity of a Smartphone Application to Detect Retinoblastoma

Study goal:

The main purpose of this study is to find out the best way to use the CRADLE app to identify leukocoria in children with retinoblastoma, congenital cataracts and glaucoma.

Diagnosis:

Retinoblastoma

Age:

7 years old or younger

Clinical trials categories:

Childhood Cancer Retinoblastoma

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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