About this study
Leukocoria is an eye condition that affects some children. Leukocoria means “white pupil.” It is the most common warning sign of retinoblastoma, a rare and serious childhood cancer of the eye. It can also be a sign of other diseases, including cataracts, glaucoma, retinal detachments and eye infections.
Currently, pediatricians and other doctors use a special tool to screen for leukocoria. This tool is called an ophthalmoscope. It allows the doctor to inspect the retina and other parts of the eye. Unfortunately, not all doctors perform this screening regularly. Even when they do screen, the ophthalmoscope may not detect retinoblastoma tumors in the eye.
In this study, researchers want to find out if a new method called CRADLE (ComputeR Assisted Detection of LEukocoria) will be better than the ophthalmoscope method at detecting leukocoria. CRADLE is a camera phone application that can be downloaded onto any smartphone device.
Purpose of this clinical trial
The main purpose of this study is to find out the best way to use the CRADLE app to identify leukocoria in children with retinoblastoma, congenital cataracts and glaucoma. Researchers hope to learn information that could help improve screening in the future, leading to earlier diagnosis of these conditions.
Eligibility overview
- 7 years old or younger
- Part I
- Diagnosed with retinoblastoma and has not received any treatment OR
- Diagnosed with cataracts and has not received any treatment OR
- Diagnosed with glaucoma and has not received any treatment
- Part II
- Referred to an eye doctor to check for leukocoria or other eye conditions
- Part III
- Diagnosed with retinoblastoma and is receiving treatment