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JZLURB: Lurbinectedin for Advanced Ewing Sarcoma

About this study

Ewing sarcoma is a cancerous tumor that is usually treated with chemotherapy, surgery and/or radiation. Sometimes, the cancer does not respond to treatment (refractory). Sometimes it comes back (relapses). Ewing sarcoma that does not respond to treatment or comes back is “advanced.” There are currently no approved treatments available for advanced Ewing sarcoma.

Lurbinectedin is a medicine that may help treat advanced Ewing sarcoma. In this study, doctors will try to find the right dose of Lurbinectedin to treat this cancer. The total amount of time a patient will be part of this study is 15–31 months.

This study will help doctors learn more about using Lurbinectedin to treat advanced Ewing sarcoma. Patients will provide blood, urine, and tumor biopsy samples.

Eligibility overview

  • Refractory or relapsed Ewing sarcoma
  • 2–30 years old
  • Has not received either lurbinectedin or trabectedin

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The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

A Phase 1/2, Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Recommended Phase 2 Dose (RP2D), and Efficacy of Lurbinectedin Monotherapy in Pediatric Participants with Previously Treated Solid Tumors Followed by Expansion to Assess Efficacy and Safety in Pediatric and Young Adult Participants with Relapsed/Refractory Ewing Sarcoma

Study goal:

To find out whether Lurbinectedin is safe in treating children and young adults who have refractory or relapsed Ewing sarcoma

Diagnosis:

Ewing sarcoma

Age:

2–30 years old

Clinical trials categories:

Childhood Cancer Solid Tumors Ewing Sarcoma

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

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