St. Jude Care & Treatment

Menu

Close

Recruiting

FUNCOGSC: Neuroimaging Cognitive Deficits in Sickle Cell Disease

About this study

This study will look at how gene therapy (replacing or repairing broken genes) and bone marrow (stem cell) transplant used to treat sickle cell disease may affect patients’ brain function.

Patients enrolled in the gene therapy studies already get MRI scans as part of treatment. If they are enrolled in FUNCOGSC also, we will get more information from their scans, which may take longer than usual. Patients will also have surveys and tests to help us look at brain functions such as:

  • IQ (intelligence)
  • Attention
  • Flexible thinking
  • Doing several tasks at once
  • Self-control
  • How well patients complete tasks they learned earlier
  • Learning and memory
  • Academic performance

Eligibility overview

  • Sickle cell disease
  • Enrolled in a bone marrow transplant or gene therapy trial such as SCDHCT or SAGES1
  • 8–25 years old

Request a referralLearn about clinical research

The above information is intended to provide only a basic description about a research protocol that may be currently active at St. Jude. The details made available here may not be the most up-to-date information on protocols used by St. Jude. To receive full details about a protocol and its status and or use at St. Jude, a physician must contact St. Jude directly.

Overview

Full title:

Functional Neuroimaging of Cognitive Deficits in Pediatric Sickle Cell Disease

Study goal:

To find out how gene therapy and bone marrow transplant affect the brain function of patients with sickle cell disease

Diagnosis:

Sickle cell disease

Age:

8–25 years old

Clinical trials categories:

Blood Disorders Sickle Cell Disease

For physicians and researchers

Patients accepted to St. Jude must be referred by a physician or other qualified medical professional. Learn how St. Jude can partner with you to care for your patient.

 

Learn more