Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

Separating fact from fiction using pharmacogenetics
Separating fact from fiction using pharmacogenetics

Separating fact from fiction using pharmacogenetics

Mary Relling, PharmD

Improving understanding of drugs and how the body reacts to them - - Read how science is improving understanding of genes and medication.

Chaperones: probing the structural secrets of the cell’s front-line protein protectors
Chaperones: probing the structural secrets of the cell’s front-line protein protectors

Chaperones: probing the structural secrets of the cell’s front-line protein protectors

Charalampos Kalodimos, PhD

Read how this protein, called a chaperone, does more than simply monitor the intracellular dance of protein folding – it protects them from going awry.

Rare childhood disorders widen window on Alzheimer’s Disease and other diseases of aging
Rare childhood disorders widen window on Alzheimer’s Disease and other diseases of aging

Rare childhood disorders widen window on diseases of aging

Mary Powers

Read how extremely rare genetic childhood diseases offer clues about understanding neurodegenerative disorders common with aging.

PeCanPIE offers powerful tools for discovering inherited cancer genes

Jinghui Zhang, PhD

Powerful cancer data portal gets an upgrade to identify the genetic culprit for inherited cancer and possibly other genetic diseases.

Pediatric immunotherapy: How two immunologists are paving the way for improved treatments
Pediatric immunotherapy: How two immunologists are paving the way for improved treatments

Pediatric immunotherapy: How two immunologists are paving the way for improved treatments

Caleigh Morr

Two friends and research colleagues are looking at different stages of the immune response to pave the way for enhanced cancer treatments.

Lando: Star Wars smuggler or possible ally against Alzheimer’s disease?
Lando: Star Wars smuggler or possible ally against Alzheimer’s disease?

Lando: Star Wars smuggler or possible ally against Alzheimer’s disease?

Mary Powers

High science calls on Star Wars character as a potential ally against Alzheimer’s disease.

SJELIOT clinical trial of children’s brain tumor therapy
SJELIOT clinical trial of children’s brain tumor therapy

SJELIOT clinical trial explores a new approach for recurring and unresponsive medulloblastoma tumors

Gary Bridgman

St. Jude is testing adult cancer drug prexasertib in children with recurrent or refractory medulloblastoma to inhibit checkpoint kinase chk1/2.

Acute lymphoblastic leukemia: collaborations in China showcase global cancer care
Acute lymphoblastic leukemia: collaborations in China showcase global cancer care

Acute lymphoblastic leukemia: collaborations in China showcase the power of global cancer care

Ching-Hon Pui, MD

An agreement between one U.S. hospital and two Chinese hospitals in 1991 has completely changed global pediatric cancer care.

Optimizing leukemia treatment through pharmaceutical science
Optimizing leukemia treatment through pharmaceutical science

Optimizing leukemia treatment through pharmaceutical science

Mary Relling, PharmD

Effective leukemia treatment is one thing – making sure it’s optimized with minimal implications is another. Read research juggles both to help patients.

Discovering how T cell 'exhaustion' is triggered could energize cancer immunotherapy
Discovering how T cell 'exhaustion' is triggered could energize cancer immunotherapy

Discovering how T cell “exhaustion” is triggered could energize cancer immunotherapy

Ben Youngblood, PhD

Read how the discovery of this gene could change immunotherapy cancer and viral infection treatments.