Research

Learn about published research as well as leading-edge basic and translational research initiatives from St. Jude laboratories.

PeCanPIE offers powerful tools for discovering inherited cancer genes

Jinghui Zhang, PhD

Powerful cancer data portal gets an upgrade to identify the genetic culprit for inherited cancer and possibly other genetic diseases.

Pediatric immunotherapy: How two immunologists are paving the way for improved treatments
Pediatric immunotherapy: How two immunologists are paving the way for improved treatments

Pediatric immunotherapy: How two immunologists are paving the way for improved treatments

Caleigh Morr

Two friends and research colleagues are looking at different stages of the immune response to pave the way for enhanced cancer treatments.

Lando: Star Wars smuggler or possible ally against Alzheimer’s disease?
Lando: Star Wars smuggler or possible ally against Alzheimer’s disease?

Lando: Star Wars smuggler or possible ally against Alzheimer’s disease?

Mary Powers

High science calls on Star Wars character as a potential ally against Alzheimer’s disease.

SJELIOT clinical trial of children’s brain tumor therapy
SJELIOT clinical trial of children’s brain tumor therapy

SJELIOT clinical trial explores a new approach for recurring and unresponsive medulloblastoma tumors

Gary Bridgman

St. Jude is testing adult cancer drug prexasertib in children with recurrent or refractory medulloblastoma to inhibit checkpoint kinase chk1/2.

Acute lymphoblastic leukemia: collaborations in China showcase global cancer care
Acute lymphoblastic leukemia: collaborations in China showcase global cancer care

Acute lymphoblastic leukemia: collaborations in China showcase the power of global cancer care

Ching-Hon Pui, MD

An agreement between one U.S. hospital and two Chinese hospitals in 1991 has completely changed global pediatric cancer care.

Optimizing leukemia treatment through pharmaceutical science
Optimizing leukemia treatment through pharmaceutical science

Optimizing leukemia treatment through pharmaceutical science

Mary Relling, PharmD

Effective leukemia treatment is one thing – making sure it’s optimized with minimal implications is another. Read research juggles both to help patients.

Discovering how T cell 'exhaustion' is triggered could energize cancer immunotherapy
Discovering how T cell 'exhaustion' is triggered could energize cancer immunotherapy

Discovering how T cell “exhaustion” is triggered could energize cancer immunotherapy

Ben Youngblood, PhD

Read how the discovery of this gene could change immunotherapy cancer and viral infection treatments.

Enzymes that unlock stress granules, our cells’ biological ‘storm shelters,’ open pathway to treating muscle, brain disorders
Enzymes that unlock stress granules, our cells’ biological ‘storm shelters,’ open pathway to treating muscle, brain disorders

Enzymes that unlock stress granules, our cells’ biological ‘storm shelters,’ open pathway to treating muscle, brain disorders

Mondira Kundu, MD, PhD

Stress granules form from heat shock to the cell then disappear, but when treated with an inhibitor to the protein ULK, the stress granules persist event after removal of the stress.

Length matters in dipeptide repeat polypeptides – and can be a way to treat ALS
Length matters in dipeptide repeat polypeptides – and can be a way to treat ALS

Length matters in dipeptide repeat polypeptides – and can be a way to treat ALS

Richard Kriwacki, PhD

Read how the length of these proteins may be an indicator of ALS.

Treatment strategies matter in childhood ALL survivorship
Treatment strategies matter in childhood ALL survivorship

Exploring survivorship: The when and how of treatment strategies matter in adult survivors of childhood ALL

Mike O’Kelly

It used to be just about surviving–now, it’s about treating children with ALL to live long, healthy lives. Learn about ALL survivorship research from ASCO.