Clinical

Find out how research at St. Jude underlies clinical progress in the care and treatment of cancer, blood disorders, neurological disease and more. 

Ewelina Mamcarz with colleagues and patient
Ewelina Mamcarz with colleagues and patient

Five years later: gene therapy for ‘bubble boy’ disease

Alex Generous, PhD

Interim results point to enduring immune function following gene therapy for Infants with ‘bubble boy’ disease

Amar Gajjar, MD., with patient Charlotte and her mother
Amar Gajjar, MD., with patient Charlotte and her mother

Reflecting on nearly 40 years of progress against pediatric brain tumors

Erin Podolak, MA

May is Brain Tumor Awareness Month and a good time to learn more about the diverse group of diseases that make up the most common childhood solid tumor.

Photo of Parent holding sick child's hand
Photo of Parent holding sick child's hand

The double-edged sword of being both parent and blood stem cell donor

Alex Generous, PhD

What are the potential psychological and emotional risks and rewards for parents who serve as their children’s bone marrow donors?

image of matches with one burnt in the middle
image of matches with one burnt in the middle

When work takes a toll: St. Jude research adds to our understanding of physician burnout.

Jonathan Burlison and Lindsay Blazin

St. Jude researchers looked at burnout and perceived work demands among St. Jude physicians and found that emotional exhaustion and time demands are key factors in a problem that affects both provider and patient.

water running down glass
water running down glass

NCCN publishes guidelines for standardized treatment of Wilms tumor

St. Jude Strategic Communication, Education and Outreach Department

The National Comprehensive Cancer Network recently published treatment guidelines for children diagnosed with nephroblastoma. Two St. Jude physicians collaborated on the project.

Cancer care during a pandemic: What we learned prepares us for the next emergency
Cancer care during a pandemic: What we learned prepares us for the next emergency

Cancer care during a pandemic: What we learned prepares us for the next emergency

Dylan Graetz, MD, MPH

The pandemic exposed shortcomings in health care. But this study revealed more than expected in this type of children’s treatment.

Different types of pediatric cancer treatments are ototoxic, or damaging to the ears. As cancer treatments become more effective and survival rates increase, we’re getting a better picture of how various treatments affect patients later on.
Different types of pediatric cancer treatments are ototoxic, or damaging to the ears. As cancer treatments become more effective and survival rates increase, we’re getting a better picture of how various treatments affect patients later on.

What we’ve found out about hearing loss and cognitive function in children

Johnnie Bass, AuD, PhD

This study, to our knowledge, is the first to objectively measure hearing and neurocognitive function in a large cohort of long-term survivors of childhood cancer stratified by treatment exposures.

Quality sickle cell disease treatment shouldn’t depend upon where you live
Quality sickle cell disease treatment shouldn’t depend upon where you live

The global burden of sickle cell disease: The quality of treatment shouldn’t depend upon where you live

Ayobami Olanrewaju, MD

Survival and quality of life for many with sickle cell disease depends upon where they live. Here’s what a doctor wants to do to fix that.

How do fathers grieve the loss of a child?
How do fathers grieve the loss of a child?

How do fathers grieve the loss of a child?

Michael J. McNeil, MD

Fathers express grief through keeping busy or focusing on work – different than a mother’s grief. But fathers may not be getting the support they need after the loss of a child.

Cultural humility ensures open, honest patient care
Cultural humility ensures open, honest patient care

Cultural humility ensures open, honest patient care

Arshia Madni, MD

Strengthening the doctor-patient bond requires a new way of thinking to help ensure open communication and the best possible care.