Division of Molecular Oncology

The Division of Molecular Oncology is a laboratory-based research group within the Department of Oncology. Our scientists lead dynamic, high impact research labs that are highly interactive with numerous collaborations among other St. Jude laboratories and shared resources.

Basic science investigations focus on the molecular and genetic determinants of pediatric cancers and the mechanisms that drive cancer development. Current areas of interest include investigations of oncogenes and tumor suppressor genes in tumor development, such as the SWI/SNF family of chromatin remodeling proteins, origins and pathology of pediatric solid tumors and leukemias, and the role of RNA splicing factor mutations in myeloid malignancies and bone marrow failure syndromes. By identifying the mechanisms underlying these diseases, Division laboratories have been able to translate novel targeted therapies to the clinic.