St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
St. Jude Family of Websites
Explore our cutting edge research, world-class patient care, career opportunities and more.
St. Jude Children's Research Hospital Home
The Center of Excellence for Leukemia Studies (CELS) was established to advance basic research and diagnosis of childhood hematological malignancies and to facilitate the translation of novel scientific findings into the clinic to improve outcomes. CELS is led by Charles Mullighan, MBBS (Hons), MSc, MD of the Department of Pathology.
CELS aims to recruit exceptional research faculty focused on hematological malignancies, create a synergistic environment among investigators to accelerate the pace of discovery, and focus research efforts on disease mechanism. To foster innovation and enhance core infrastructure, CELS has established core resources in several key areas: flow cytometry, single cell technologies and metabolomics.
CELS brings together new and existing investigators researching leukemia in a collaborative enterprise that will serve to establish St. Jude as a global leader in hematological malignancies and have a sustained impact in improving cure rates.
DNA FISH showing colocation with nuclear condensates using light-activated macromolecular phase separation (LAMPS)
The presence of histiocytic granuloma in a genetic mouse model of AML
Circulating leukemic blasts in a genetic mouse model of AML
DNA FISH showing intrachromosomal amplification of chromosome 21 (iAMP21; green).
RNA-seq-based UMAP plot of molecular subtypes in pediatric AML
HEK293T cells transfected with GFP-tagged NUP98::LNP1, fixed and stained for interacting protein H3K14ac (red) and DAPI (blue).
Gene regulatory processes controlling stem cell development and blood cancers
Molecular drives behind bone marrow failure and leukemia predisposition syndromes
Genomic drivers of leukemia and treatment failure
Molecular and biological causes of pediatric myeloid tumors
The CELS core resources are committed to assisting investigators in achieving and maintaining excellence in research. Providing access to innovative technologies, CELS has three state-of-the-art staff-operated facilities: flow cytometry, single cell technologies and metabolomics. These facilities are led by Kathryn Roberts, PhD, Director of Scientific Research for CELS and the Department of Pathology.
Kathryn Roberts, PhD – Director of Scientific Research
Kebreeya Bailey – Sr. Administrative Specialist
Amit Kumar, MS – Scientist, CELS Single Cell Technologies
Hieu (Danny) Vu, PhD – Lead Scientist, CELS Metabolomics Core
Pooja Singh – Associate Scientist, Flow Cytometry Core
Josi Lott – Lead Researcher, Flow Cytometry Core
Shaohua Lei, PhD – Sr. Bioinformatics Research Scientist
Xiaoming Zhong, PhD – Sr. Bioinformatics Research Scientist