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About CELS

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The Center of Excellence for Leukemia Studies (CELS) was established to advance basic research and diagnosis of childhood hematological malignancies and to facilitate the translation of novel scientific findings into the clinic to improve outcomes. CELS is led by Charles Mullighan, MBBS (Hons), MSc, MD of the Department of Pathology.

CELS aims to recruit exceptional research faculty focused on hematological malignancies, create a synergistic environment among investigators to accelerate the pace of discovery, and focus research efforts on disease mechanism. To foster innovation and enhance core infrastructure, CELS has established core resources in several key areas: flow cytometry, single cell technologies and metabolomics.

CELS brings together new and existing investigators researching leukemia in a collaborative enterprise that will serve to establish St. Jude as a global leader in hematological malignancies and have a sustained impact in improving cure rates.

CELS Research Groups

Jian Xu

Dr. Jian Xu Lab

Gene regulatory processes controlling stem cell development and blood cancers

Jian Xu

Dr. Alyssa Kennedy Lab

Molecular drives behind bone marrow failure and leukemia predisposition syndromes

Jian Xu

Dr. Charles Mullighan Lab

Genomic drivers of leukemia and treatment failure

Jian Xu

Dr. Jeff Klco Lab

Molecular and biological causes of pediatric myeloid tumors

Selected publications

Core Resources

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The CELS core resources are committed to assisting investigators in achieving and maintaining excellence in research. Providing access to innovative technologies, CELS has three state-of-the-art staff-operated facilities: flow cytometry, single cell technologies and metabolomics. These facilities are led by Kathryn Roberts, PhD, Director of Scientific Research for CELS and the Department of Pathology. 

Advanced Technology and Genome (ATG) Core

The ATG Core was established under the leadership of Dr. Jian Xu and aims to advance pediatric cancer research through the development of innovative technologies and strong collaborations.


PROPEL

Public Resource of Patient-derived and Expanded Leukemias (PROPEL) is one of the world’s largest repositories of patient-derived xenografts for adult and pediatric leukemias and is designed to accelerate discovery and cures for acute leukemias.

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Join Our Team

CELS is actively recruiting faculty who are motivated to undertake research focused on understanding hematological malignancies.

CELS Staff

Kathryn Roberts, PhD – Director of Scientific Research

Kebreeya Bailey – Sr. Administrative Specialist

Amit Kumar, MS – Scientist, CELS Single Cell Technologies

Hieu (Danny) Vu, PhD – Lead Scientist, CELS Metabolomics Core

Pooja Singh – Associate Scientist, Flow Cytometry Core

Josi Lott – Lead Researcher, Flow Cytometry Core

Shaohua Lei, PhD – Sr. Bioinformatics Research Scientist

Xiaoming Zhong, PhD – Sr. Bioinformatics Research Scientist