Scientists from St. Jude Children’s Research Hospital will present research at the American Association for Cancer Research (AACR) annual meeting. The five-day international conference begins March 29 in Atlanta.
Team Science
On Sunday, the Cancer Control and Survivorship Program at St. Jude will receive the 13th AACR Team Science Award during the meeting’s opening ceremony. The award recognizes innovative, interdisciplinary research that has advanced understanding or treatment of cancer. Read the Press Release.
St. Jude Cloud
St. Jude Cloud will showcase its growth since the data-sharing platform premiered at the 2018 AACR annual meeting. The platform now includes 10,000 sequenced whole genomes from pediatric cancer patients, survivors and others.
Visit our Booths
St. Jude Cloud at #4136
Academic Programs and Recruitment at #4139
Cancer & Biomedical Research Career Fair at #CF303
Educational Sessions
Genetic Predispositions to Childhood Leukemias: Implications for Pathogenesis and Screening
Friday, March 29
Room A302
Educational Session ED32
5:15 – 5:40 p.m.
Jun J. Yang, PhD, of the Hematological Malignancies Program, will discuss 10 years of genomic discovery regarding inherited susceptibility to acute lymphoblastic leukemia.
6:15 – 6:40 p.m.
Jeffery Klco, MD, PhD, of Department of Pathology, will discuss the recently identified pediatric myeloid disease disposition genes SAMD9 and SAMD9L.
Advances in Organ Site Research: Genetic Predisposition in Hematologic Malignancies
Monday, April 1
Room B401
Educational Session AOS01
1:30 – 1:55 p.m.
Jeffery Klco, MD, PhD, of Department of Pathology, will discuss genetic data and mechanistic insights into the emerging syndrome of germline SAMD9/SAMD9L mutations in childhood myelodysplasia and monosomy 7.
2:00 – 2:25 p.m.
Charles Mullighan, MBBS, MD, of the Department of Pathology, will discuss germline determinants of susceptibility and drug response in acute lymphoblastic leukemia. Mullighan is also chairing the session.
Science of Survivorship: The intersection of survivorship and aging
Monday, April 1
Georgia Ballroom 3 - Building C
Forum FO07-297
5:30 - 6:30 p.m.
Kirsten Ness, PhD, of the Department of Epidemiology and Cancer Control, will participate in a forum about the biologic intersection of cancer and aging, including the increased risk for frailty and chronic health conditions in childhood cancer survivors.
Poster Sessions
-
1:00 - 5:00 p.m.
Clinical genomic sequencing uncovers potentially targetable truncations and fusions in MAP3K8 in spitzoid and other melanomas
Scott Newman, PhD, of the Department of Computational Biology
Cancer Genomics 1
Section 33
Presentation Number: 731 -
8:00 a.m. - Noon
Acquisition of drug resistance mutations during chemotherapy treatment in pediatric acute lymphoblastic leukemia
Samuel Brady, PhD, of the Department of Computational Biology
Targets and Therapies in Pediatric Cancer
Section 6
Presentation Number: 2872Analysis of error profiles in deep next-generation sequencing data
Xiaotu Ma, PhD, of the Department of Computational Biology
High-throughput Sequencing
Section 36
Presentation Number: 35381:00 - 5:00 p.m.
Increased prevalence of germline monoallelic RECQL4 mutations in children with cancer
Jamie Maciaszek, PhD, of the Department of Oncology
Biology and Signaling in Pediatric Cancer
Section 2
Presentation Number: 3651USP7 heterozygous loss-of-function affects T-cell differentiation in pediatric T-ALL
Timothy Shaw, PhD, of the Department of Computational Biology
Biology and Signaling in Pediatric Cancer
Section 2
Presentation Number: 3652Visualize 10,000 whole-genomes from pediatric cancer patients on St. Jude Cloud
Clay McLeod, of the Department of Computational Biology
Biology and Signaling in Pediatric Cancer
Section 2
Presentation Number: 3671Single-cell characterization and lineage tracking of recurrent pediatric rhabdomyosarcoma
Anand Patel, MD, of the Department of Oncology
Tumor Evolution and Heterogeneity 2
Section 7
Presentation Number: 3768Germline mutations in BRCA2 and pediatric/adolescent non-Hodgkin’s lymphoma: A report from the St. Jude Lifetime (SJLIFE) and Childhood Cancer Survivor Study (CCSS) cohorts
Zhaoming Wang, PhD, of the Department of Epidemiology and Cancer Control
Cancer Predisposition
Section 26
Presentation Number: 4178 -
8:00 a.m. - Noon
Modeling the vascular sarcoma spectrum with genetically engineered mice
Jason Hanna, PhD, of the Department of Oncology
Mouse Models
Section 6
Presentation Number: 4631Whole-genome sequencing of childhood cancer survivors treated with cranial radiation therapy identifies 5p15.33 locus for stroke: A report from the St. Jude Lifetime Cohort (SJLIFE) study
Yadav Sapkota, PhD, of the Department of Epidemiology and Cancer Control
Supportive Care and Survivorship Research/Outcome Research
Section 20
Presentation Number: 4909Researchers at St. Jude have identified a chromosomal region associated with an increased risk of stroke among adult survivors of childhood cancer treated with cranial radiation therapy. This investigation draws on whole genome sequencing data gathered through the St. Jude Lifetime Cohort (SJLIFE) study. The investigators found a significant association between variants on a chromosomal region called 5p15.33, dose level of cranial radiation therapy and risk of stroke. These results suggest that testing for variants of 5p15.33 may be useful for identifying patients who, when treated with cranial radiation therapy, will be at a high-risk of stroke as adults. “This is one of the first studies to evaluate the genomic underpinnings of stroke in such a robust cohort,” said Yadav Sapkota, PhD, of the St. Jude Department of Epidemiology and Cancer Control.
Acute depletion of CTCF directly affects MYC regulation through loss of enhance-promoter looping
Chunliang Li, PhD, of the Department of Tumor Cell Biology
Mechanisms and Consequences of Transcriptional Deregulation
Section 36
Presentation Number: 5228Genomic instability and the development of high-grade glioma
Lee Pribyl, of the Department of Genetics
Late-Breaking Research: Molecular and Cellular Biology/Genetics 2
Section 41
Presentation Number: LB-289
Representatives from St. Jude Cloud will be available to answer questions in the Exhibit Hall at Booth #4136. Learn about the unique resources and data available for researchers, including GenomePaint. Attend a demonstration:
Making Discoveries on St. Jude Cloud
Scott Newman, PhD
Monday, April 1 at 10:30 – 11:30 a.m.
Tuesday, April 2 at 2:00 – 3:00 p.m.
Announcing and Investigating GenomePaint
Alex Gout, PhD
Monday, April 1 at 2:00 – 3:00 p.m.
Tuesday, April 2 at 10:30 – 11:30 a.m.
Representatives from the St. Jude Office of Academic Programs and the St. Jude Children's Research Hospital Graduate School for Biomedical Sciences will be available to answer questions in the Exhibit Hall at Booth #4139.
Saturday, March 30
9:00 a.m. – 3:00 p.m.
Booth CF303
Representatives from St. Jude Children’s Research Hospital will be available to answer questions on positions for post-docs, researchers, clinical fellows and more.