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Breaking the dogma: Key cell death regulator has more than one way to get the job done
12/23/2019
Scientists explain how cell death caused from this protein could lead to drug treatments to prevent the inflammatory, cell-killing response of septic shock.
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Models for Wilms tumor research
12/20/2019
Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor.
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Diagnostic test helps find bloodstream infections before they appear
12/19/2019
Researchers at St. Jude Children’s Research Hospital are testing a game-changing technique for predicting infection in patients with weakened immune systems.
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Elizabeth Fox, M.D., named senior vice president of clinical trials research at St. Jude Children’s Research Hospital
12/16/2019
Elizabeth Fox, M.D. will oversee clinical trials research administration and strategy and serve as the associate director for clinical research.
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Research reveals how muscles talk to the brain to regulate feeding behavior
12/12/2019
A study from St. Jude Children’s Research Hospital sheds light on the mechanisms governing feeding behavior in fruit flies and how skeletal muscle communicates energy needs to the brain.
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Researchers reprogram T cells to improve cancer immunotherapy
12/11/2019
Read about a molecule that researchers are targeting in hopes of improving cancer immunotherapy, including CAR-T cell therapy, against solid tumors as well as leukemia.
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ASH: Research revises classification of acute myeloid leukemia and myelodysplastic syndrome
12/10/2019
Findings presented by a St. Jude Children’s Research Hospital investigator showcase the power and potential of combining genomic and transcriptomic data.
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ASH annual meeting highlights St. Jude research
12/02/2019
Researchers from St. Jude Children’s Research Hospital will present their work at the 61st annual meeting of the American Society of Hematology.
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International collaboration yields insights into childhood leukemia risk
11/25/2019
Researchers know that different biology underlies CLL and ALL. However, there may be a link between the two diseases.
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St. Jude researchers among the most highly cited in 2019
11/22/2019
Nearly 20 scientists from St. Jude Children's Research Hospital named Highly Cited Researchers for 2019 by the Web of Science group.
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Gene therapy for X-linked SCID wins 2019 Smithsonian Magazine American Ingenuity Award
11/19/2019
Gene therapy developed by the late Brian Sorrentino honored by Smithsonian Magazine.
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Justin Baker of St. Jude finalist for Schwartz Center’s National Compassionate Caregiver of the Year Award
11/18/2019
Dr. Justin Baker is one of six finalists for the National Compassionate Caregiver of the Year Award.
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Understanding transporter proteins at a single-molecule level
11/13/2019
Research co-led by a St. Jude investigator and researchers from Columbia University and the New York State Psychiatric Institute reveals the mechanics of how some transporter proteins function with stunning specificity.
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Chemotherapy sometimes sets the stage for drug-resistant leukemia at relapse
11/01/2019
An International collaboration has identified therapy-induced, drug-resistance mutations in children with acute lymphoblastic leukemia who relapse.
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Treating the TOTAL patient: clinical trial reduces relapse
10/28/2019
Researchers at St. Jude have announced results of the Total Therapy Study 16 clinical trial, which tested strategies for lowering the rate of relapse of acute lymphoblastic leukemia in children from 2007–2017.
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Controlling the immune system’s brakes to treat cancer, autoimmune disorders
10/24/2019
St. Jude researchers have discovered two enzymes that may have a crucial role in treating autoimmune disorders and certain cancers.
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Exercise may give the brain a boost
10/21/2019
A St. Jude study reveals more about the link between cancer survivors’ physical fitness and their thinking and learning skills.
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Childhood cancer survivorship data portal in St. Jude Cloud launched at ASHG
10/18/2019
A St. Jude Children’s Research Hospital online portal into pediatric cancer survivorship data debuts at the American Society of Human Genetics annual meeting.
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St. Jude and IAEA partner to tackle childhood cancers in developing countries
10/18/2019
St. Jude and the IAEA partner to raise awareness of childhood cancers, increase professional training, and support research in pediatric radiation oncology.
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Do vitamins A and D help the flu vaccine work better? It depends.
10/08/2019
Vitamins A and D can impact how well some children respond to the flu vaccine.
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Douglas R. Green receives Yale Graduate School’s Wilbur Lucius Cross Medal
10/04/2019
Douglas R. Green, Ph.D., is one of four recipients of the 2019 Wilbur Lucius Cross Medal for Alumni Achievement from the Yale Graduate School.
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Research reveals structural details of chaperones, critical molecules of the cell
09/20/2019
St. Jude scientists have uncovered a new discovery that reveals how chaperones manage protein folding – which could lead to finding ways to fight disease.
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Meet the newest employees of St. Jude Children's Research Hospital, Puggle and Huckleberry
09/17/2019
St. Jude launches a Paws at Play hospital dog program to help pediatric patients cope with the challenges of treatment and hospitalization.
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Meet the molecule that helps stressed cells decide between life and death
09/11/2019
How do stressed cells choose between survival or death? Evidence suggests the molecule DDX3X plays a role and offers a possible strategy for controlling chronic inflammation.
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World’s largest and most powerful Nuclear Magnetic Resonance Spectrometer arrives at St. Jude
09/06/2019
New NMR will allow St. Jude researchers to study proteins, DNA, RNA and other biomolecules to better understand catastrophic diseases.
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How sweet it is: PeCanPIE serves up cancer variants
09/05/2019
Powerful cancer data portal gets an upgrade to identify the genetic culprit for inherited cancer and possibly other genetic diseases.
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Researchers move beyond sequencing and create a 3D genome
09/04/2019
Scientists have used a 3D genome to improve understanding of gene regulation during development and disease. Read the latest.
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Monitoring infection in patients with compromised immune systems
09/03/2019
Digital polymarese chain reaction testing can correlate the amount of virus present in a sample with clinical systems.
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Taking a wider view reveals potential targets for rhabdoid tumors
08/27/2019
New study finds new rhabdoid tumor targets by identifying which targets these tumors need to survive.
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Novel beta-thalassemia treatment shows promise in preclinical tests
08/21/2019
A fresh take on the common blood disorder, b-thalassemia leads researchers to a novel therapy using rapamycin that is ready for clinical trial.
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St. Jude names Dr. Aseem Ansari chair of Department of Chemical Biology and Therapeutics
08/15/2019
Aseem Ansari, Ph.D., will join St. Jude Children’s Research Hospital as chair of the Department of Chemical Biology and Therapeutics.
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Global childhood cancer burden grows when years of life lost considered
07/29/2019
A new study has for the first time looked at the global burden of pediatric cancer through the lens of years of affected and lost life.
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Inherited BRCA2 mutations linked to increased risk of childhood lymphoma
07/25/2019
Research from St. Jude Children’s Research Hospital has found that prominent cancer risk gene BRCA2 can increase risk of non-Hodgkin lymphoma in children and adolescents.
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To understand a childhood brain tumor, researchers turn to single-cell analysis
07/24/2019
Research at St. Jude Children’s Research Hospital and Massachusetts General Hospital digs into the cells of origin for key medulloblastoma subtypes.
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Rare inherited enzyme disorder yields insight into fibrosis
07/17/2019
St. Jude Children’s Research Hospital scientists discovered an association between a mutation that causes a lysosomal storage disorder and fibrotic conditions, including idiopathic pulmonary fibrosis
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DNA replication machinery captured at atom-level detail
07/15/2019
St. Jude Children’s Research Hospital scientists reveal a crystal structure that illustrates a mechanism that powers and possibly starts DNA replication.
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Pathway discovered that prevents buildup of Alzheimer’s protein
06/27/2019
A new pathway called LANDO may protect against neurodegeneration in Alzheimer's disease. Learn about how inhibiting this pathway may positively affect treatment.
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Childhood leukemia cannot hide from the immune system
06/26/2019
St. Jude scientists found that despite having few mutations, pediatric acute lymphoblastic leukemia does not escape immune detection.
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Goldilocks principle helps explain the origins of the most common children’s cancer
06/26/2019
This study provided the first detailed genomic and epigenomic map of the IGH-DUX4 rearrangement and suggested the principle a model for the IGH-DUX4 contribution to B-ALL.
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U.S. News & World Report ranks St. Jude as outstanding Pediatric Cancer Hospital
06/17/2019
St. Jude Children’s Research Hospital is ranked as the No. 2 pediatric cancer hospital on U.S. News & World Report’s 13th Annual “Best Children’s Hospitals” list.
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Researchers discover key genetic trigger that compromises cancer immunotherapy
06/17/2019
T cell exhaustion has proven to be an obstacle for immunotherapy, and investigators hope their basic findings will result in techniques to prevent exhaustion.
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St. Jude Cloud to accelerate scientific discoveries through access to real-time clinical genome sequencing data
05/28/2019
The platform is the first to release prospective, comprehensive clinical whole-genome sequencing data directly from the clinic to the cloud.
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Research reveals possible strategy for blocking the spread of pneumococcal disease
05/21/2019
Researchers found about 70 bacterial proteins that played an important role in transmission, and suggest combination vaccines to block and prevent invasive disease.
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ASCO annual meeting highlights St. Jude research and leadership
05/20/2019
The work of St. Jude Children’s Research Hospital will be on display at the 55th annual meeting of the American Society of Clinical Oncology in Chicago
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Schedule changes improve treatment for acute lymphoblastic leukemia
05/20/2019
Scheduling delivery of the drug asparaginase with a discontinuous schedule of dexamethasone helps reduce bone damage when the two drugs were given together.
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How is lifelong immune response to flu shaped in infancy? St. Jude leads study to find out
05/20/2019
St. Jude chosen to lead an international effort to define how flu infections early in life shape the immune response to virus.
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Here’s another reason to cover your cough (or sneeze)
05/20/2019
Research shows how flu and respiratory bacteria work together to gain a foothold in the respiratory tract, and the first report of flu sticking to surface of respiratory bacteria.
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St. Jude at ASCO 2019
05/13/2019
St. Jude experts present pediatric oncology and survivorship research at the annual meeting of the American Society of Clinical Oncology.
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St. Jude physician-scientist receives AACR award
05/06/2019
The 2019 Gertrude B. Elion Cancer Research Award supports researchers to advance research focused on the cause, diagnosis, treatment or prevention of cancer.
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Hearing loss weakens skills that young cancer survivors need to master reading
05/02/2019
In the first study to identify the key cognitive components that lead to reading problems, researchers identify potential interventions to help survivors become better readers.
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Martine Roussel, Ph.D., of St. Jude elected to the National Academy of Sciences
05/01/2019
Roussel’s appointment marks a historic moment in National Academy of Sciences history with a record number of women elected to the academy.
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Researchers solve a mystery regarding how cell division gets dialed up
04/30/2019
Unchecked cell division leads to cancer. The fluctuations in the intrinsically disordered protein p27 helps keep the process on track.
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Study links patrolling monocytes to lupus-related kidney disease
04/29/2019
The findings suggest that patrolling monocytes may drive glomerulonephritis, inflammation of the kidneys. Exploring these mechanisms may lead to new drug targets.
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Charles Mullighan named St. Jude Comprehensive Cancer Center deputy director
04/25/2019
The new role will help guide precision medicine and preclinical efforts as well as other strategic research initiatives.
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St. Jude gene therapy cures babies with 'bubble boy' disease
04/17/2019
Novel combination gene therapy pioneered at St. Jude cures "bubble boy" disease and provides template for treating other genetic disorders. Read about the landmark study.
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St. Jude Children’s Research Hospital and the World Federation of Hemophilia announce collaboration
04/17/2019
Collaboration will improve the understanding of how advanced technologies, such as gene therapy for hemophilia B, can move rapidly to countries with limited resources.
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Research reveals how the most common ALS mutation dooms cells
04/10/2019
Toxic DPRs disrupt cell function in ALS, much like uninvited dinner party guests, and displace binding partners that help maintain normal nucleolus and ribosome assembly.
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Biochemical switches identified that could be triggered to treat muscle, brain disorders
04/10/2019
Enzymes ULK1 and ULK2 play a key role in breaking down cell structures called stress granules, whose persistence leads to toxic buildup of proteins that kill muscle and brain cells
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St. Jude Children's Research Hospital selected as a finalist in Fast Company magazine's World Changing Ideas Awards
04/09/2019
The recognition was earned for sharing several decades worth of genetic cancer data and a five-year collaboration with World Health Organization.
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St. Jude at AACR 2019
04/02/2019
Explore research and resources by St. Jude at the 2019 Annual Meeting of the American Association for Cancer Research (AACR) in Atlanta.
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AACR: Genetic study identifies a risk factor for stroke among cancer survivors
04/02/2019
This investigation draws on whole genome sequencing and other data gathered longitudinally through the St. Jude Lifetime Cohort (SJLIFE) study.
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Inherited genetic variation linked to risk of T cell leukemia in children
04/01/2019
The study identified a novel variant of the USP7 gene as playing a role in increasing the risk of developing T-ALL. The inherited genetic variant is linked to lower expression of USP7.
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Tracking the source of bone cancer mutations
04/01/2019
Read about efforts to improve cure rates for the bone cancer osteosarcoma by tracking how the chemo drug cisplatin may contribute to mutations.
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AACR highlights and honors St. Jude research from the laboratory to the clinic
03/29/2019
Research ranges on a variety of topics such as survivorship, clinical genomics, deep sequencing, disease models and the biology of pediatric cancers.
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Genomic analysis offers roadmap for diagnosis and treatment of a high-risk leukemia
03/29/2019
Genomic analysis reveals the biology of acute erythroid leukemia, a rare cancer with few survivors
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American Association for Cancer Research honors Cancer Control and Survivorship Program
03/28/2019
The St. Jude Cancer Control and Survivorship Program is a multidisciplinary research program which strives to improve the quality of life of individuals surviving childhood cancer.
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St. Jude strengthens collaboration to improve pediatric cancer care in Asia
03/26/2019
The agreement reflects the St. Jude commitment to transform pediatric cancer care in low- to moderate-income nations that are home to 90 percent of childhood cancer patients.
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Researchers develop method to dramatically reduce error rate in next-generation sequencing
03/13/2019
Check out what happens when math and biology combine to tackle error rates in next-generation DNA sequencing. The answer is good news for cancer patients.
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American Society of Clinical Oncology honors St. Jude president and CEO
03/13/2019
Downing will discuss our understanding of the molecular landscape of childhood cancer, which can benefit cancer patients of all ages and raise global cancer cure rates.
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Genomic testing of a single patient reveals a gene commonly mutated in pediatric melanoma
03/04/2019
Comprehensive clinical genomic testing proves its worth; leads to discovery of a mutation that drives the most common childhood melanoma.
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Radiation after surgery triples survival for a type of pediatric brain tumor
03/01/2019
Cooperative clinical trial gives immediate postoperative radiation for children under age 3 with ependymoma, illustrates effectiveness of postoperative radiation.
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Genetic variations in a fourth gene linked to elevated leukemia risk in Hispanic children
02/14/2019
Progress reported on understanding why Hispanic children are more likely to develop acute lymphoblastic leukemia and to die of the disease.
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St. Jude Children’s Research Hospital named to Fortune magazine’s “100 Best Companies to Work For’ for ninth consecutive year
02/14/2019
The institution is the highest-ranked Memphis-based organization; for nearly a decade, Fortune has recognized the hospital’s commitment to employee
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St. Jude Children’s Research Hospital honored as recipient of the 2019 Microsoft Health Innovation Awards
02/13/2019
St. Jude Children’s Research Hospital announced it has been named a recipient of Microsoft Corp.’s 2019 Health Innovation Awards.
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Customized drug interaction alerts address alert fatigue, protect patients
02/13/2019
Researchers developed a method for customizing and reducing drug interaction alerts in electronic health records for pediatric cancer patients.
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St. Jude Children’s Research Hospital Graduate School of Biomedical Sciences launches Master of Science degree program
02/04/2019
New program will integrate traditional training and experiential learning at St. Jude campus and partner site.
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St. Jude researchers discover key genomic 'management' partners in brain development
02/04/2019
The study reports how two unexpected partners, the proteins UTX and 53BP1, link up to regulate a brain development program comprising hundreds of genes.
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St. Jude collaboration offers research road map to improve pediatric patient care
01/23/2019
Survey results should help health system leaders and patient safety experts dedicate resources to improve safety and clinical outcomes in pediatric health care.
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No substantial benefit from transplantation reported for a high-risk leukemia subtype
01/18/2019
Children with hypodiploid acute lymphoblastic leukemia fare better when minimal residual disease is used to guide treatment.
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More accurate leukemia diagnosis expected as researchers refine leukemia classification
01/14/2019
Research led by St. Jude Children's Research Hospital means more than 90 percent of the most common cases of childhood cancer can now be classified by subtype, an advance likely to fuel precision medicine.
