MAGE-A11 inhibitor for cancer (SJ-20-0033)

St. Jude Reference #SJ-20-0033

Description

Researchers at St. Jude discovered a first-in-class small molecule inhibitor of Melanoma-associated antigen (MAGE) for the treatment of various cancers including lung, ovarian, and medulloblastoma. The inhibitor prevents MAGE-A11 ubiquitin ligase from binding to its substrate, PCF11. MAGE-A11 is normally restricted to expression in reproductive tissues (e.g. testis), but is aberrantly expressed in many tumors. It has been shown that MAGE-A11 acts as an oncogene, and depletion of MAGE-A11 slows cancer cell growth and tumor formation in vivo. Consequently, the discovery of MAGE-A11 inhibitors could have commercial applications as cancer-specific therapeutics.

Most cancer therapeutics are non-cancer specific with detrimental side effects, and no therapeutics are directedly inhibiting MAGE proteins. Thus, MAGE-directed therapeutics may have advantage due to its relatively restricted expression pattern. Our discovery may lead to the development of first-in-class cancer retreatments. 

Keywords

small molecule inhibitor, Melanoma-associated antigen (MAGE), cancer, lung, ovarian, medulloblastoma, MAGE-A11 ubiquitin ligase, PCF11 substrate, E3 ligase, protein degradation

Granted patents or published applications

Provisional application pending.

Related scientific references

Licensing opportunities

More information is available under a confidentiality  agreement. Contact: chad.riggs@stjude.org

Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.