Gene therapy vector insulator elements (SJ-20-0026)

St. Jude Reference #SJ-20-0026

Description

Researchers at St. Jude identified hundreds of human genome DNA fragments with strong enhancer blocking activities in lymphocytes.

These insulators can be incorporated into viral vectors to prevent enhancer mediated oncogene activation by vector enhancer elements, and thus enhance the safety of the vectors. These safer vectors can be used therapeutically to treat a variety of different diseases.

Keywords

Genome, DNA, fragment, enhancer blocking activity, lymphocytes. Biologic, viral vector, insulator, cancer

Granted patents or published applications

Pending international application published as WO 2021/231192

Related scientific references

Licensing opportunities

We are currently seeking licensing opportunities in the described fields for the development and use of this technology. Contact: chad.riggs@stjude.org

Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.