CD33 CAR (SJ-17-0010)

St. Jude Reference #SJ-17-0010

Description

Researchers at St. Jude remade an anti-CD33 chimeric antigen receptor (CAR) that incorporates a 4-1BB-CD3ζ signaling tail previously proven effective in clinical trials. This CAR targets CD33 even at effector to target (E:T) ratios of less than one, which may allow for clinical potency even in the setting of high tumor burden. Treatment with specific inhibitors during ex vivo CAR T cell expansion modulated the differentiation program of CAR T cells, preserving a less differentiated phenotype, and improved in vivo persistence without disruption of normal ex vivo proliferation. It therefore, can be incorporated into CAR T cell production regimens without impacting yield. This is important as the inability to produce adequate CAR T cell numbers for treatment remains a significant limitation.

Keywords

anti-CD33 chimeric antigen receptor (CAR), 4-1BB-CD3ζ signaling tail, CD33

Granted patents or published applications

Pending patent application published as US-2021-0030793-A1

Related scientific references

Zheng W, O'Hear CE, Alli R, Basham JH, Abdelsamed HA, Palmer LE, Jones LL, Youngblood B, Geiger TL. “PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells.” Leukemia. 2018 May;32(5):1157-1167. doi: 10.1038/s41375-017-0008-6. Epub 2018 Feb 2.

Licensing opportunities

St. Jude is seeking a partner or partners to help develop this for use with therapies. Contact: chad.riggs@stjude.org.

Contact the Office of Technology Licensing (Phone: 901-595-2342, Fax: 901-595-3148) for more information.