Center for In Vivo Imaging and Therapeutics (CIVIT)
The CIVIT is staffed by PhD-level scientists for consultation and experimental design and highly skilled Research Technologists to provide imaging, surgery, and preclinical therapeutic services.
OVERVIEW
The mission of the Center for In Vivo Imaging and Therapeutics (CIVIT) is to facilitate the use of cutting-edge imaging and image-guided therapy technologies to advance the research of St. Jude investigators. The CIVIT is staffed by PhD-level scientists for consultation and experimental design and highly skilled Research Technologists to provide imaging, surgery, and preclinical therapeutic services. Preclinical imaging modalities include bioluminescence imaging (BLI), high resolution ultrasound (US), intravital multiphoton microscopy, magnetic resonance imaging (MRI), micro-computed tomography (µCT), positron emission tomography (PET), and image-guided radiation therapy (IGRT) Imaging (MRI, PET/CT, BLI, US, intravital microscopy) and surgical procedures are conducted within a barrier housing facility, facilitating studies utilizing severely immunocompromised models.
IMPACT
CIVIT enables St. Jude investigators to conduct high-density, complex preclinical studies at reasonable cost with expert input. CIVIT supports the work of investigators across the institution and has been acknowledged as a contributor on almost 200 peer-reviewed publications.
The imaging capabilities of St. Jude have transformed my lab. We would not have been able to conduct our meaningful studies without the intensive work from CIVIT.
Joseph Opferman, Associate Member
Services
- Bioluminescence and fluorescence imaging
- High resolution ultrasound and ultrasound-guided injections
- Intravital multiphoton microscopy
- Magnetic resonance imaging and spectroscopy
- Micro-computed tomography
- Positron emission tomography
- Image guided radiation therapy
- Microsurgery techniques including orthotopic PDX implants
Equipment
- Xenogen IVIS-200 imaging system
- VisualSonics VEVO-3100 High-Resolution Imaging System
- Bruker Biospec 9.4T with Cryoprobe system
- Siemens Inveon multi-modal instrument encompassing both µPET and µCT capabilities
- Clinical Leica M525/F20 surgical microscope
- Small Animal Radiation Research Platform (SARRP, Xstrahl) incorporates CT imaging and tilting Xray source with adjustable collimator
- Olympus FVMPE-RS multiphoton laser scanning microscope
- IVIS Spectrum and IVIS-200 Bioluminescence imaging systems
