2021 Archive

graphic representation of math in medicine
graphic representation of math in medicine
Research

Math behind the medicine

Brian O'Flynn, PhD and Jessie Newman

Explore how mathematics influences all that we do at St. Jude

table displaying clinical trial info
table displaying clinical trial info
St. Jude On

The collaborative journey of rare disease clinical research

Jill Granger, MS

Recruiting patients to participate in clinical research for rare diseases requires collaboration between patients, families, and care teams.

Artistic rendering showing calendar months going by from left to right, with three versions of a person with sickle cell disease experiencing worse outcomes the longer they take to transition to adult care.
Artistic rendering showing calendar months going by from left to right, with three versions of a person with sickle cell disease experiencing worse outcomes the longer they take to transition to adult care.
Clinical

Shortening the gap between pediatric and adult care improves sickle cell outcomes

Alex Generous, PhD

Closing the time gap between pediatric and adult care could have significant benefits for patients.

woman writing on glass board
woman writing on glass board
St. Jude On

Behind the curtain: the key role of biostatistics in advancing clinical trials

LaToyia P. Downs, PhD

Explore how biostatistics drives the design and implementation of clinical trials at St. Jude.

Kristin Stephenson
Kristin Stephenson
Investigator Insights

5 Questions for Kristin Stephenson, MHA, JD

Brian O'Flynn, PhD and Kristin Stephenson, MHA, JD

Learn how Kristin Stephenson, MHA, JD, has developed the Office of Strategy & Alliances as the hub of harmonization for the Pediatric Translational Neuroscience Initiative.

a pair of hands holding a piece of paper with dots on it, near a person wearing a medical coat with a St. Jude logo
a pair of hands holding a piece of paper with dots on it, near a person wearing a medical coat with a St. Jude logo
St. Jude On

Translating lab discoveries to clinical trials in the age of personalized medicine

Brian O'Flynn, PhD

See how research is translated to clinical impact in addressing the most challenging ALL cases

Illustrationn of a diverse group of people outside the National Institutes of Health
Illustrationn of a diverse group of people outside the National Institutes of Health
Outreach

Study explores emotional entanglement and belonging in a research immersion program

LaToyia P. Downs, PhD

Learn about a study exploring emotions and belonging in STEMM research immersion programs

A woman and man looking at a computer screen that shows an image of cells
A woman and man looking at a computer screen that shows an image of cells
Research

The long and the short of the cell antenna

Brian O'Flynn, PhD

Explore the pathway linking Sonic Hedgehog signaling with cilium length

A man and a woman sitting on a hospital bed and talking to each other
A man and a woman sitting on a hospital bed and talking to each other
Clinical

Bone marrow transplantation for sickle cell disease improves myocardial fibrosis

Erin Podolak, MA

St. Jude scientists have found for the first time that myocardial fibrosis caused by sickle cell disease can actually be improved by bone marrow transplantation.

two men talking one is holding a report
two men talking one is holding a report
Research

Exploring biomolecular condensate networks’ internal structure

Brian O'Flynn, PhD

See how molecular dynamics revealed the inhomogeneous nature of biomolecular condensates

Lisa Jacola
Lisa Jacola
Research

Pain may be a risk factor for learning problems in childhood cancer survivors

Mary Powers

Researchers are focusing on treatment-related pain as another way to reduce the risk of learning and memory problems in survivors of childhood leukemia.

Lecture series logo
Lecture series logo
Investigator Insights

Rising Stars of Cancer Research lectures to bring fresh insights

Mary Powers

The Rising Stars of Cancer Research program is a new to the Science of Childhood Cancer lecture series. The program highlights the work of emerging leaders in the cancer research community.

global
global
Outreach

St. Jude Global Alliance holds third annual convening

Lance Wiedower

Empower Everyone was the theme of the St. Jude Global Alliance Convening, a virtual meeting that attracted participants from around the world.

CoNGA
CoNGA
Research

CoNGA: Deciphering the dance of T-cell differentiation

Stefan Schattgen, PhD

St. Jude scientists have created an algorithm to help group T-cells by their function by evaluating two different types of data, T-cell receptor sequences and gene expression.

Walter Hughes sits at a desk early in his career
Walter Hughes sits at a desk early in his career
Investigator Insights

St. Jude mourns the death of infectious diseases pioneer Walter Hughes, MD

Mike O’Kelly

Walter Hughes, MD, who established the St. Jude Department of Infectious Diseases and initiated pediatric AIDS research at the hospital, has died.

Haitao Pan, PhD
Haitao Pan, PhD
Research

St. Jude biostatisticians create a novel clinical trial design software

St. Jude Progress

St. Jude biostatisticians have developed a new method for designing phase 2 clinical trials with a small sample size. The approach uses a mathematical model called Bayesian probability . The researchers created free software to implement the process.

Meeting graphic
Meeting graphic
Research

Bringing Chemistry to Medicine: Transcription therapy symposium is set for July 22 and 23

Mike O’Kelly

St. Jude will host the virtual Bringing Chemistry to Medicine Symposium July 22–23. The inaugural event in 2020 prompted a researcher in India to become a visiting scientist at St. Jude. Register for the event.

image of matches with one burnt in the middle
image of matches with one burnt in the middle
Clinical

When work takes a toll: St. Jude research adds to our understanding of physician burnout.

Jonathan Burlison and Lindsay Blazin

St. Jude researchers looked at burnout and perceived work demands among St. Jude physicians and found that emotional exhaustion and time demands are key factors in a problem that affects both provider and patient.

Stronger Together
Stronger Together
Investigator Insights

Connections with colleagues: A St. Jude pediatric psychologist has renewed appreciation for an overlooked benefit of interdisciplinary collaboration.

Elyse Heidelberg, PsyD

A pediatric psychologist expresses gratitude for interdisciplinary collaboration, which elevates patient care and provider well-being.

Martine Roussel, PhD, stands for a portrait with her lab blurred out in the background.
Martine Roussel, PhD, stands for a portrait with her lab blurred out in the background.
Investigator Insights

Roussel’s early discovery shaped a career of cancer research

St. Jude Communications Department

Martine Roussel, PhD, faculty member and endowed chair in molecular oncogenesis, shares how early work on oncogenes led to her lab’s discovery of new oncogenes.