Tara M. Brinkman, PhD

Behavioral and psychosocial late effects of childhood cancer treatment can significantly impact the quality of life and health of survivors. For example, we have shown that stress and psychological distress are associated with the long-term cardiovascular health of survivors, independent of traditional and treatment-related cardiovascular risk factors. 

In the Department of Epidemiology and Cancer Control, I conduct collaborative research to improve our understanding of psychosocial late effects, particularly the long-term emotional, social, and behavioral outcomes of pediatric cancer and its treatments. Our approach involves characterizing these late effects, understanding their impact on survivors’ health and daily functioning, and developing interventions to ameliorate these late effects and their consequences.

An ongoing research study conducted through St. Jude LIFE involves characterizing psychosocial morbidity to better understand how individual indicators of psychosocial health co-occur. These indicators of psychosocial health include survivors’ emotional health status, health behaviors, socioeconomic status, and ability to achieve independence as adults. We examine the impact of psychosocial morbidity on the chronic health conditions, quality of life, and mortality in adult survivors of childhood cancer.

Beyond characterization of late effects, I am interested in conducting interventions to improve long-term outcomes for survivors of childhood cancer. I am the co-principal investigator on an eHealth intervention in the Childhood Cancer Survivor Study. This web-based, cognitive behavioral therapy intervention is designed for survivors who have symptoms of insomnia. We investigate the effects of this intervention on sleep, neurocognitive function, cardiovascular health, and quality of life in survivors.

Another intervention we conduct focuses on improving executive dysfunction in adult survivors of childhood leukemia. This study involves computerized cognitive training paired with transcranial direct current stimulation (tDCS), a non-invasive form of brain stimulation. We assess improvements in executive function using objective cognitive testing, self-report of perceived cognitive impact on daily life, and changes in brain function/activity using neuroimaging techniques.

We also are developing additional studies with tDCS to improve pain and sleep in survivors of childhood cancer.

Understanding and improving the psychosocial consequences of childhood cancer and its treatment is crucial as we try to improve quality of life and health outcomes for patients and survivors of childhood cancer.