The Future of Spatial Omics in Cancer and Beyond was a special virtual symposium on Thursday, June 2, 2022. Major advances in next-generation sequencing and imaging-based approaches have led to a revolution in our ability to measure gene expression in tissue sections while preserving cellular organization. Spatial-omics approaches are increasingly powerful when combined with single-cell RNA-seq to provide a detailed map of cellular heterogeneity and tissue organization.
This half-day virtual symposium featured the leading experts in spatial omics, who are developing new platforms and applying them to answer fundamental questions about cellular interactions during development and disease. The event, organized in association with The Science of Childhood Cancer Lecture Series, was collaboratively hosted by the St. Jude Comprehensive Cancer Center and Departments of Developmental Neurobiology, Immunology and Computational Biology, and the St. Jude Center for Spatial Omics (CSO).
Opening Remarks
Charles W.M. Roberts, MD, PhD & Mike Dyer, PhD
St. Jude Children's Research Hospital
The Spatial Ecosystem in Tumors Analyzed by Transcriptome and Genome-Wide Technologies
Joakim Lundeberg, PhD
Professor, KTH Royal Institute of Technology at SciLifeLab
Spatial Multi-Omics Sequencing via Deterministic Barcoding in Tissue
Rong Fan, PhD
Professor, Department of Biomedical Engineering, Yale University
Professor, Department of Pathology, Yale School of Medicine
Computational Approaches to Mapping Structure in Tissues
Dana Pe'er, PhD
Chair, Computational and Systems Biology Program, Sloan Kettering Institute
Scientific Director, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center
Investigator, Howard Hughes Medical Institute
Understanding Brain Cell Type Diversity
Hongkui Zeng, PhD
Executive Vice President and Director, Allen Institute for Brain Science
Closing Remarks
Michael Dyer, PhD
Member, St. Jude Faculty
Hosts
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- Chair, Developmental Neurobiology Department
- Co-Leader, Developmental Biology & Solid Tumor Program
- Department of Developmental Neurobiology
- Comprehensive Cancer Center
- St. Jude Graduate School of Biomedical Sciences
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- Executive Vice President
- Director, Comprehensive Cancer Center
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- Interim Chair, Department of Computational Biology
- Department of Computational Biology
- Comprehensive Cancer Center
- St. Jude Graduate School of Biomedical Sciences
| Time CDT | Activity |
|---|---|
| 9:00 – 9:15 am | Opening remarks Charles W.M. Roberts, MD, PhD Michael Dyer, PhD |
| 9:15 – 10:05 am | The Spatial Ecosystem in Tumors Analyzed by Transcriptome and Genome-Wide Technologies Joakim Lundeberg, PhD KTH Royal Institute of Technology at SciLifeLab Moderator: Paul G. Thomas, PhD |
| 10:05 – 10:55 am | Spatial Multi-Omics Sequencing via Deterministic Barcoding in Tissue Rong Fan, PhD Yale University Moderator: Jiyang Yu, PhD |
| 10:55 – 11:15 am | Break |
| 11:15 am – 12:05 pm | Computational Approaches to Mapping Structure in Tissues Dana Pe'er, PhD Sloan Kettering Institute and Howard Hughes Medical Institute Moderator: Jiyang Yu, PhD |
| 12:05 – 12:55 pm | Understanding Brain Cell Type Diversity Hongkui Zeng, PhD Allen Institute for Brain Science Moderator: Paul G. Thomas, PhD |
| 12:55 – 1:05 pm | Closing remarks Michael Dyer, PhD |
At St. Jude Children’s Research Hospital, we seamlessly integrate basic, translational and clinical research to advance cures for catastrophic childhood diseases. Over the past decade, we have led major efforts to profile the genomic landscape of pediatric cancers and integrated those data with transcriptomic, epigenetic and proteomic data. With recent advances in single-cell profiling using next-generation sequencing platforms, researchers at St. Jude are now elucidating the cellular heterogeneity of pediatric cancer and other experimental models.
Single-cell transcriptome profiling combined with spatial assay platforms provides an unprecedented opportunity to elucidate the cellular heterogeneity in normal development, cancer and other catastrophic childhood diseases. Our strength in advanced microscopy, computational biology, cancer modeling and the rich resource of tissue samples provide a unique opportunity to accelerate discovery and advance cures.
As part of the 2022-2027 St. Jude Strategic Plan , we are building a new institutional shared resource focused on implementing cutting edge spatial omics platforms. The St. Jude Center for Spatial Omics (CSO) is proud to lead this groundbreaking endeavor. Our experience as part of the Human Tumor Atlas Pilot Project and Human Tumor Atlas Network has provided us with the expertise to rapidly accelerate development of this unique resource to serve all investigators at St. Jude.
Join our team
We are currently recruiting a director for this new shared resource who will create a bold vision to navigate the rapidly changing research advances in spatial omics today and in the future. Multiple staff positions will also be available. Join our team to contribute to our mission to save lives and improve the quality of life for children with cancer and other devastating diseases.
Find Jobs in the St. Jude Comprehensive Cancer Center and Departments of Developmental Neurobiology, Immunology, and Computational Biology.