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Min Ni, PhD
Min Ni, PhD

Min Ni, PhD

Assistant Member, St. Jude Faculty

Departments

Divisions

Education

  • PhD (Biochemistry and Molecular Biology) - University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA
  • MS (Molecular Oncology) - Medical Center of Fudan University, Shanghai Cancer Institute, Shanghai, China
  • BS (Biology) Wuhan University, Wuhan, China

Honors & Awards

  • 2013  Award for Genetics and Genomics of Breast and Gyn Cancers, Harvard Cancer Center
  • 2011  AACR-Aflac Incorporated Scholar-In-Training Award, American Association for Cancer Research
  • 2009-2012  Department of Defense (DOD) Breast Cancer Research Postdoctoral Award
  • 2008  Wang Scholarship Award in Cancer Research, USC
  • 2007  Charles Heidelberger Memorial Predoctoral Scholarship Award in Cancer Research, USC

Research Interests

  • Genetic and metabolic control of development
  • Pediatric cancer metabolism
  • Metabolomics in systems biology

Selected Publications

Wu Z, Bezwada D, Cai F, Harris RC, Ko B, Sondhi V, Pan C, Vu HS, Nguyen PT, Faubert B, Cai L, Chen H, Martin-Sandoval M, Do D, Gu W, Zhang Y, Zhang Y, Brooks B, Kelekar S, Zacharias LG, Oaxaca KC, Patricio JS, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ. Electron transport chain inhibition increases cellular dependence on purine transport and salvage. Cell Metab. June 7 2024. doi:10.1016/j.cmet.2024.05.014

Scheuerle AE, Ni M, Ahmad AA, Timmons CF, Rakheja D, Gordon EE, Boothe M. Biallelic variants in NUDCD2 associated with a multiple malformation syndrome with cholestasis and renal failure. Am J Med Genet A. Jun 5, 2023. doi: 10.1002/ajmg.a.63314. PMID: 37272762

Lyu J, Liu Y, Gong L, Chen M, Madanat YF, Zhang Y, Cai F, Gu Z, Cao H, Kaphle P, Kim YJ, Kalkan FN, Stephens H, Dickerson KE, Ni M, Chen W, Patel P, Mims AS, Borate U, Burd A, Cai SF, Yin CC, You MJ, Chung SS, Collins RH, DeBerardinis RJ, Liu X, Xu J. Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance. Cancer Discov Jan 9;13(1):170-193, 2023. PMID: 36222845.

Patrick M, Gu Z, Zhang G, Wynn RM, Kaphle P, Cao H, Vu H, Cai F, Gao X, Zhang Y, Chen M, Ni M, Chuang DT, DeBerardinis RJ, Xu J. Metabolon formation regulates branched-chain amino acid oxidation and homeostasis. Nat Metab Dec;4(12):1775-1791, 2022. PMID: 36443523

Solmonson A, Faubert B, Gu W, Rao A, Cowdin MA, Menendez-Montes I, Kelekar S, Rogers TJ, Pan C, Guevara G, Tarangelo A, Zacharias LG, Martin-Sandoval MS, Do D, Pachnis P, Dumesnil D, Mathews TP, Tasdogan A, Pham A, Cai L, Zhao Z, Ni M, Cleaver O, Sadek HA, Morrison SJ, DeBerardinis RJ. Compartmentalized metabolic activities support midgestation mammalian development. Nature Apr;604(7905):349-353, 2022. PMID: 35388219.

Ni M#, Black LF, Pan C, Vu H, Pei J, Ko B, Cai L, Solmonson A, Yang C, Nugent KM, Grishin NV, Xing C, Roeder E, DeBerardinis RJ#. Metabolic impact of pathogenic variants in the mitochondrial glutamyl-tRNA synthetase EARS2. Journal of Inherited Metabolic Disease Jul;44(4):949-960, 2021. PMID: 33855712 #Co-corresponding author

Ni M#, Afroze B, Xing C, Pan C, Shao Y, Cai L, Cantarel BL, Pei J, Grishin NV, Hewson S, Knight D, Mahida S, Michel D, Tarnopolsky M, Poduri A, Rotenberg A, Sondheimer N, DeBerardinis RJ#. A pathogenic UFSP2 variant in an autosomal recessive form of pediatric neurodevelopmental anomalies and epilepsy. Genetics in Medicine May;23(5):900-908, 2021. PMID: 33473208 #Co-corresponding author

Huang F, Huffman KE, Wang Z, Wang X, Li K, Cai F, Yang C, Cai L, Shih TS, Zacharias LG, Chung A, Yang Q, Chalishazar MD, Ireland AS, Stewart CA, Cargill K, Girard L, Liu Y, Ni M, Xu J, Wu X, Zhu H, Drapkin B, Byers LA, Oliver TG, Gazdar AF, Minna JD, DeBerardinis RJ. Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. J Clin Invest Jan;131(1): e139929, 2021. PMID: 33079728

Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, Dickerson KE, Chen M, Chen W, Shao Z, Ni M, Xu J. Non-Coding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies. Cancer Discov 10(5):724-745, 2020. PMID: 32188707

Li K, Liu Y, Cao H, Zhang Y, Gu Z, Liu X, Yu A, Kaphle P, Dickerson KE, Ni M, Xu J. Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing. Nat Commun 11(1):485, 2020. PMID: 31980609

Gu Z, Liu Y, Cai F, Patrick M, Zmajkovic J, Cao H, Zhang Y, Tasdogan A, Chen M, Qi L, Liu X, Li K, Lyu J, Dickerson KE, Chen W, Ni M, Merritt ME, Morrison SJ, Skoda RC, DeBerardinis RJ, Xu J. Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformation. Cancer Discov 9(9):1228-1247, 2019. PMID: 31189531

Ni M#, Solmonson A, Pan C, Yang C, Li D, Notzon A, Cai L, Guevara G, Zacharias LG, Faubert B, Vu HS, Jiang L, Ko B, Morales NM, Pei J, Vale G, Rakheja D, Grishin NV, McDonald JG, Gotway GK, McNutt MC, Pascual JM, and DeBerardinis RJ#. Functional Assessment of Lipoyltransferase-1 Deficiency in Cells, Mice, and Humans. Cell Reports 2019, 27:1376-1386, 2019. PMID: 31042466 #Co-corresponding author

Huang F, Ni M, Chalishazar MD, Huffman KE, Kim J, Cai L, Shi X, Cai F, Zacharias LG, Ireland AS, Li K, Gu W, Kaushik AK, Liu X, Gazdar AF, Oliver TG, Minna JD, Hu Z, DeBerardinis RJ. Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancer. Cell Metabolism Sep 4;28(3):369-382.e5, 2018. doi: 10.1016/j.cmet.2018.06.005. PMID: 30043754

Faubert B, Li KY, Cai L, Hensley CT, Kim J, Zacharias LG, Yang C, Do QN, Doucette S, Burguete D, Li H, Huet G, Yuan Q, Wigal T, Butt Y, Ni M, Torrealba J, Oliver D, Lenkinski RE, Malloy CR, Wachsmann JW, Young JD, Kernstine K, DeBerardinis RJ. Lactate Metabolism in Human Lung Tumors. Cell 171(2):358-371, 2017. PMID: 28985563

Liu X, Zhang Y, Chen Y, Li M, Zhou F, Li K, Cao H, Ni M, Liu Y, Gu Z, Dickerson KE, Xie S, Hon GC, Xuan Z, Zhang MQ, Shao Z, Xu J. In situ capture of chromatin interactions by biotinylated dCas9. Cell 170(5):1028-1043, 2017. PMID: 28841410

Liu X*, Zhang Y*, Ni M*, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation. Nature Cell Biology 19(6):626-638, 2017. PMID: 28504707 *Co-first author

Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature 546(7656):168-172, 2017. PMID: 28538732.

Hensley CT, Faubert B, Yuan Q, Lev-Cohain N, Jin E, Kim J, Jiang L, Ko B, Skelton R, Loudat L, Wodzak M, Klimko C, McMillan E, Butt Y, Ni M, Oliver D, Torrealba J, Malloy CR, Kernstine K, Lenkinski RE, DeBerardinis RJ. Metabolic Heterogeneity in Human Lung Tumors. Cell 164(4):681-94, 2016. PMID: 26853473

Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Peluffo G, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer EP, Letai A, Barry WT, Carroll JS, Long HW, Brown M, Liu XS, Meyer CA, Bradner JE, Polyak K. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature 529(7586):413-7, 2016. PMID: 26735014

Chen X, Iliopoulos D, Zhang Q, Tang Q, Greenblatt M, Hatziapostolou M, Lim M, Tam WL, Ni M, Chen Y, Mai J, Shen H, Hu D, Adoro S, Hu B, Song M, Tan C, Landis M, Ferrari M, Shin S, Brown M, Chang J, Liu XS, Glimcher L. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 508(7494):103-7, 2014. PMID: 24670641

Ni M, Chen Y, Teng Fei, Dan Li, Lim E, Liu XS, Brown M. Amplitude modulation of androgen signaling by c-MYC. Genes & Development 27(7):734-48, 2013. PMID: 23530127

Wey S, Luo B, Tseng C, Ni M, Zhou H, Fu Y, Bhojwani D, Carroll WL, Lee AS. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling. Blood 119(3): 817-25, 2012. PMID: 21937694

Ni M*, Chen Y*, Lim E, Wimberly H, Bailey ST, Imai Y, Rimm DL, Liu XS, Brown M. Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell 20(1):119-31, 2011. PMID: 21741601 *Co-first author

Ye R, Ni M, Wang M, Luo S, Zhu G, Chow RH, Lee AS. Inositol 1,4,5-trisphosphate receptor 1 mutation perturbs glucose homeostasis and enhances susceptibility to diet-induced diabetes. J Endocrinol 210(2):209-17, 2011. PMID: 21565852

Baba A, Ohtake F, Okuno Y, Yokota K, Okada M, Imai Y, Ni M, Meyer CA, Igarashi K, Kanno J, Brown M, Kato S. PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. Nature Cell Biol 13(6):668-75, 2011. PMID: 21532585

Zhang Y, Liu R, Ni M, Gill P, and Lee AS. Cell surface relocalization of the endoplasmic reticulum chaperone and unfolded protein response regulator GRP78/BiP. Journal of Biol Chem 285(20):15065-75, 2010. PMID: 20208072

Xu J, Sankaran V, Ni M, Menne T, Puram R, Kim W, and Orkin SH. Transcriptional silencing of γglobin by BCL11A involves long-range interactions and cooperation with SOX6. Genes & Development 24(8):783-98, 2010. PMID: 20395365

He H, Meyer CA, Shin H, Bailey S, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M, Liu XS. Nucleosome dynamics defines transcriptional enhancers. Nature Genetics 42(4):343-7, 2010. PMID: 20208536

Zhang Q, Gu J, Li L, Liu J, Luo B, Cheung HW, Boehm JS, Ni M, Geisen C, Root DE, Polyak K, Brown M, Richardson AL, Hahn WC, Kaelin WG Jr., Bommi-Reddy A. Control of cyclin D1 and breast tumorigenesis by the EgIN2 prolyl hydroxylase. Cancer Cell 16(5):413-24, 2009. PMID: 19878873

Ni M, Zhou H, Wey S, Baumeister P, Lee AS. Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One 4(8):e6868, 2009. PMID: 19718440

Last update: October 2023

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