Selected Publications
Hinze L, Schreek S, Zeug A, Ibrahim NK, Fehlhaber B, Loxha L, Cinar B, Ponimaskin E, Degar J, McGuckin C, Chiosis G, Eckert C, Cario G, Bornhauser B, Bourquin JP, Stanulla M, Gutierrez A. Supramolecular assembly of GSK3α as a cellular response to amino acid starvation. Molecular Cell 2022;82:2858.
Bodaar K, Yamagata N, Barthe A, Landrigan J, Ni Chonghaile T, Burns M, Stevenson KE, Devidas M, Loh ML, Hunger SP, Wood B, Silverman LB, Teachey DT, Meijerink JP, Letai A, Gutierrez A. JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia. Leukemia 2022;36:1499.
Orellana E, Liu Q, Yankova E, Pirouz M, De Braekeleer E, Zhang W, Lim J, Aspris D, Sendinc E, Garyfallos D, Gu M, Ali R, Gutierrez A, Mikutis S, Bernardes G, Fischer E, Bradley A, Vassiliou G, Slack F, Tzelepis K, Gregory R. METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation. Molecular Cell 2021;81:3323.
Burns MA, Place AE, Stevenson KE, Gutierrez A, Forrest S, Pikman Y, Vrooman LM, Harris MH, Hunt SK, O’Brien JE, Asselin BL, Athale UH, Clavell LA, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Sulis ML, Welch JJG, Neuberg DS, Sallan SE, Silverman LB. Identification of prognostic factors in childhood T-cell acute lymphoblastic leukemia: Results from DFCI ALL Consortium Protocol 05-001 and 11-001. Pediatr Blood Cancer. 2021;68:e28719.
Hinze L, Labrosse R, Degar J, Han T, Schatoff EM, Schreek S, Karim S, McGuckin C, Sacher J, Wagner F, Yuan C, Sicinska E, Stanulla M, Giannakis M, Ng K, Dow LE, Gutierrez A. Exploiting the therapeutic interaction of Wnt pathway activation and asparaginase for colorectal cancer therapy. Cancer Discovery 2020;10:1690.
Garcia EG, Veloso A, Oliveira ML, Allen JR, Loontiens S, Brunson D, Do D, Yan C, Morris R, Iyer S, Garcia SP, Iftimia N, Van Loocke W, Matthijssens F, McCarthy K, Barata J, Speleman F, Taghon T, Gutierrez A, Van Vlierberghe P, Haas W, Blackburn JS, Langenau DM. PRL3 enhances T-cell acute lymphoblastic leukemia growth through suppressing T-cell signaling pathways and apoptosis. Leukemia. 2021;35:679.
Tao T, Shi H, Wang M, Perez-Atayde AR, London WB, Gutierrez A, Lemos B, Durbin AD, Look AT. Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors. J Exp Med 2020;217:e20191871.
Hinze L, Pfirrman M, Karim S, Degar J, McGuckin C, Vinjamur D, Sacher J, Stevenson KE, Neuberg DS, Orellana E, Stanulla M, Gregory RI, Bauer DE, Wagner F, Stegmaier K, Gutierrez A. Synthetic lethality of Wnt pathway activation and asparaginase in drug-resistant acute leukemias. Cancer Cell 2019;35:664.
Pouliot GP, Degar J, Hinze L, Kochupurakkal B, Vo CD, Burns MA, Moreau L, Ganesa C, Roderick J, Peirs S, Menten B, Loh ML, Hunger SP, Silverman LB, Harris MH, Stevenson KE, Weinstock DM, Weng AP, Kelliher MA, Van Vlierberghe P, D’Andrea AD, Gutierrez A. Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. Plos One 2019;14:e0221288.
Aries IM, Bodaar K, Karim SA, Ni Chonghaile T, Hinze L, Burns M, Pfirrmann M, Degar J, Landrigan J, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin KR, Winter SS, Dunsmore KP, Wood B, Silverman LB, Sallan SE, Van Vlierberghe P, Orkin SH, Knoechel B, Letai A, Gutierrez A. PRC2 inactivation induces primary chemotherapy resistance by repressing mitochondrial apoptosis in T-cell acute lymphoblastic leukemia. J Exp Med 2018;215:3094.
Burns MA, Liao ZW, Yamagata N, Pouliot GP, Stevenson KE, Neuberg DS, Thorner AR, Ducar M, Silverman EA, Hunger SP, Loh ML, Winter SS, Dunsmore KP, Wood B, Devidas B, Harris MH, Silverman LB, Sallan SE, Gutierrez A. Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia. Leukemia 2018;32:2126.
Gutierrez A, Kentsis A. Acute myeloid/T-lymphoblastic leukemia (AMTL): A distinct category of acute leukemias with common pathogenesis in need of improved therapy. British Journal of Haematology 2018;180:919.
Mansour M, He S, Li Z, Lobbardi R, Abraham B, Hug C, Rahman S, Leon T, Kuang YY, Zimmerman M, Blonquist T, Gjini E, Gutierrez A, Tang Q, Garcia-Perez L, Pike-Overzet K, Anders L, Berezovskaya A, Zhou Y, Zon L, Neuberg D, Fielding A, Staal F, Langenau D, Sanda T, Young R, Look AT. JDP2: an oncogenic bZIP transcription factor in T-cell acute lymphoblastic leukemia. J Exp Med 2018;215:1929.
Cooper M, Choi J, Staser K, Ritchey J, Niswonger J, Eckard K, Rettig M, Wang B, Eissenberg L, Ghobadi A, Gehrs L, Prior J, Achilefu S, Miller C, Fronick C, O’Neal J, Gao F, Weinstock D, Gutierrez A, Fulton R, Dipersio J. An ‘off-the-shelf’ fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies. Leukemia 2018;32:1970.
Lobbardi R, Pinder J, Martinez-Pastor B, Blackburn J, Abraham B, Namiki Y, Mansour M, Abdelfattah N, Molodtsov A, Alexe G, Toiber D, de Waard M, Jain E, Lion M, Bhere D, Shah K, Gutierrez A, Stegmaier K, Silverman L, Sadreyev R, AsaraJ, Oettinger M, Haas W, Look AT, Young R, Mostoslavsky R, Dellaire G, Langenau D. TOX regulates growth, DNA repair and genomic instability in T-cell acute lymphoblastic leukemia. Cancer Discovery 2017;7:1336.
Simon-Carrasco L, Grana O, Salmon M, Jacob HKC, Gutierrez A, Jimenez G, Drosten M, Barbacid M. Inactivation of Capicua in adult mice causes T cell lymphoblastic lymphoma. Genes & Development. 017;31:1456.
Townsend EC, Murakami M, Christodoulou A, Christie AL, Koester J, DeSouza T, Morgan E, Kallgren S, Liu H, Wu SH, Plana O, Boronat JM, Stevenson K, Armand P, Ballen K, Cahill S, Clark R, Cooke V, Davids M, DeAngelo, D, Dorfman D, Eaton H, Ebert B, Firestone B, Fisher D, Freedman A, Galinsky I, Garcia J, Garnache-Ottou F, Graubert T, Gao H, Gutierrez A, Herbert Z, Horwitz SM, Inghirami G, Intlekoffer A, Izraeli S, Jacobsen E, Jacobson C, Jeremias I, Kelliher M, Koch R, Konopleva M, Kopp N, Kung AL, Kupper T, LaBeouf N, Lees E, Li L, Muschen M, Neuberg D, Ng S, Odejide O, Orkin S, Place A, Roderick J, Sallan S, Shoji B, Silverman LB, Soiffer R, Steensma D, Stegmaier K, Stone RM, Tamburini J, Thorner A, van Hummelen P, Vadleigh M, Weigert O, Weng A, Williams DA, Lane AA, Letai A, Bertagnolli M, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. The Public Repository of Xenografts (ProXe) enables discovery and randomized phase II-like trials in mice. Cancer Cell 2016;29:574.
Knoechel B, Bhatt A, Pan L, Sekhar Pedamallu C, Severson E, Gutierrez A, Dorfman D, Kuo F, Kung A, Zweidler-McKay P, Meyerson M, DeAngelo DJ, Aster JC. Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the gamma-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Molecular Case Studies 2015;1:a000539.
Suarez A, Pina M, Nichols-Vinueza DX, Lopera J, Rengifo L, Mesa M, Cardenas M, Morrissey L, Veintemilla G, Vizcaino M, Del Toro L, Vicuna V, Fernandez J, Neuberg D, Stevenson K, Gutierrez A. A strategy to improve treatment-related mortality and abandonment of therapy for childhood ALL in a developing country reveals the impact of treatment delays. Pediatr Blood Cancer 2015;62:1395.
Mansour MR, Abraham BJ, Anders L, Berezovskaya A, Gutierrez A, Durbin AD, Etchin J, Lawton L, Sallan SE, Silverman LB, Loh ML, Hunger SP, Sanda T, Young RA, Look AT. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element. Science 2014;346:1373.
Reynolds C, Roderick JE, LaBelle JL, Bird G, Mathieu R, Bodaar K, Colon D, Pyati U, Stevenson KE, Qi J, Harris M, Silverman LB, Sallan SE, Bradner JL, Neuberg DS, Look AT, Walensky LD, Kelliher MA, Gutierrez A. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia 2014;28:1819.
Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour M, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsh L, Bury L, Meyer C, Ke N, Mulry K, Kluk M, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale R, Linch D, Zhao J, Mullighan CG, Harper W, Aster J, Aifantis I, von Boehmer H, Gygi S, Wei W, Look AT, Sicinski P. Cyclin C is a haploinsufficient tumor suppressor. Nature Cell Biology 2014;16:1080.
Ni Chonghaile T, Roderick JE, Glenfield C, Sallan SE, Silverman LB, Loh ML, Hunger SP, Wood B, DeAngelo DJ, Stone R, Harris M, Gutierrez A, Kelliher MA, Letai A. Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199. Cancer Discovery 2014;4:1074.
Gutierrez A, Pan L, Groen R, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, Verplank L, An F, Burbank J, Norton S, Tolliday N, Steen H, Weng AP, Yuan H, Bradner JE, Mitsiades C, Look AT, Aster JC. Phenothiazines induce PP2A-mediated apoptosis in T-cell acute lymphoblastic leukemia. J Clin Invest 2014;124:644.
Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Look AT, Harris MH, Silverman LB, Sallan SE, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE. An epigenetic mechanism of resistance to targeted therapy in T-cell acute lymphoblastic leukemia. Nature Genetics 2014;46:364.
Nichols-Vinueza DX, Veintemilla G, Perez-Atayde AR, Gutierrez A. Pseudopapillary tumor of the pancreas in a child with hemihypertrophy and a history of Wilms tumor. Pediatr Blood Cancer 2014;61:1091.
Gutierrez A, Feng H, Stevenson K, Neuberg DS, Calzada O, Zhou Y, Langenau DM, Look AT. Loss of function p53 mutations do not accelerate the onset of Myc-induced T-ALL in the zebrafish. Br J Haematol 2014;166:84.
Roderick JE, Tesell J, Shultz LD, Brehm MA, Greiner DL, Harris MH, Silverman LB, Sallan SE, Gutierrez A, Look AT, Qi J, Bradner JE, Kelliher MA. Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood 2014;123:1040.
Zuurbier L, Gutierrez A, Mullighan CG, Cante-Barret K, Gevaert AO, de Rooi J, Smits WK, Buijs-Gladdines JG, Sonneveld E, den Boer ML, Look AT, Horstman M, Pieters R, Meijerink JP. Immature/early t-cell precursor acute lymphoblastic leukemia patients treated on the COALL-97 protocol are not associated with poor outcome. Haematologica 2014;99:94.
Mansour MR, Sanda T, Lawton LN, Li X, Kreslavsky T, Novina CD, Brand M, Gutierrez A, Kelliher MA, Jamieson C, von Boehmer H, Young RA, Look AT. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T-cell acute lymphoblastic leukemia. J Exp Med 2013;210:1545.
Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Muller M, Gray NS, Jamieson CHM, Weng AP, Staudt JM, Druker BJ, Look AT. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discovery 2013;3:564.
Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa R, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecs T, Hunger SP, Timakhov R, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor Lin28B. Blood 2012;120:3764.
Sanda T, Lawton LN, Barrasa MI, Fan ZP, Kohlhammer H, Gutierrez A, Ma W, Tatarek J, Ahn Y, Kelliher MA, Jamieson CHM, Staudt LM, Young RA, Look AT. Core transcriptional regulatory circuit controlled by the TAL1 complex in human T-cell acute lymphoblastic leukemia. Cancer Cell 2012;22:209.
Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH. NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches. PLoS One 2012;7:e39725.
Gutierrez A, Snyder EL, Marino-Enriquez A, Zhang Y, Sioletic S, Kozakewich E, Grebliunate R, Ou WB, Sicinska E, Raut CP, Demetri GD, Perez-Atayde AR, Wagner AJ, Fletcher JA, Fletcher CDM, Look AT. Aberrant AKT activation drives well-differentiated liposarcoma. Proc Natl Acad Sci U S A 2011;108:16386.
Gutierrez A, Grebliunaite R, Feng H, Kozakewich E, Zhu S, Guo F, Payne E, Mansour M, Dahlberg SE, Neuberg DS, den Hertog J, Prochownik EV, Testa JR, Harris M, Kanki JP, Look AT. Pten mediates Myc oncogene dependence in a conditional zebrafish model of T-cell acute lymphoblastic leukemia. J Exp Med 2011;208:1595.
Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter S, Hunger SP, Sallan SE, Zha S, Alt FW, Downing JR, Mullighan CG, Look AT. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood 2011;118:4169.
Rudner LA, Brown KH, Dobrinski DP, Bradley DF, Garcia MI, Smith ACH, Downie JM, Meeker ND, Look AT, Downing JR, Gutierrez A, Mullighan CG, Schiffman JD, Lee C, Trede NS, Frazer JK. Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene 2011;30:4289.
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser R, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look AT, Nakayama KI, DePinho RA, Wei W. SCF-FBW7 regulates cellular apoptosis by targeting Mcl-1 for ubiquitination and destruction. Nature.2011;471:104.
Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Kutok J, Larson RS, Borowitz MJ, Loh ML, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT. Absence of biallelic TCRg deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. J Clin Oncol 2010;28:3816.
Feng H, Stachura DL, White RM, Gutierrez A, Zhang L, Sanda T, Jette CA, Testa JR, Neuberg DS, Langenau DM, Kutok JL, Zon LI, Traver D, Fleming MD, Kanki JP, Look AT. T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1 and ICAM1 leading to a blockade of tumor cell intravasation. Cancer Cell 2010;18:353.
Gutierrez A, Sanda T, Ma W, Zhang J, Grebliunaite R, Dahlberg S, Neuberg D, Protopopov A, Winter S, Larson R, Borowitz M, Silverman LB, Chin L, Hunger S, Jamieson C, Sallan SE, Look AT. Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood 2010;115:2845.
Sanda T, Li X, Gutierrez A, Ahn Y, Neuberg DS, O’Neil J, Strack PS, Winter CG, Winter SS, Larson R, von Boehmer H, Look AT. Interconnecting Molecular Pathways in the Pathogenesis and Drug Sensitivity of T-cell Acute Lymphoblastic Leukemia. Blood 2010;115:1735.
Penning TM, Lee SH, Jin Y, Gutierrez A, Blair IA. Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications. J Steroid Biochem Mol Biol 2010;121:546.
Grace RF, Su H, Sena L, Poussaint TY, Heeney MM, Gutierrez A. Resolution of cerebral artery stenosis in a child with sickle cell anemia treated with hydroxyurea. Am J Hematol 2009;85:135.
Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, Ahn Y, Dahlberg S, Neuberg D, Moreau LA, Winter SS, Larson R, Zhang J, Protopopov A, Chin L, Pandolfi PP, Silverman LB, Hunger SP, Sallan SE, Look AT. High Frequency of PTEN, PI3K and AKT abnormalities in T cell acute lymphoblastic leukemia. Blood 2009;114:647.
Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radke I, Downing JR, Fleming MD, Macconaill LE, Amatruda JF, Gutierrez A, Galinski I, Stone RM, Ross EA, Pellman DS, Kanki JP, Look AT. Emi1 Maintains Genomic Integrity during Zebrafish Embryogenesis and Cooperates with p53 in Tumor Suppression. Mol Cell Biol 2009;29:5911.
O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT. Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med 2007;204:3059.
Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, Depinho RA. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 2007;447:966.
Feng H, Langenau DM, Madge JA, Quinkertz A, Gutierrez A, Neuberg DS, Kanki JP, Look AT. Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br J Haematol 2007;138:169.
Singh G, Gutierrez A, Xu K, Blair IA. Liquid chromatography/electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range. Anal Chem 2000;72:3007.
Last update: April 2025