Sk Mohiuddin Choudhury, DVM, MS, PhD

Lead Researcher

Departments

Department of Oncology

Divisions

Cancer Predisposition Division

Education

DVM – Bangladesh Agricultural University, Bangladesh
MS – Bangladesh Agricultural University, Bangladesh
PhD – Lanzhou Veterinary Research Institute, CAAS, China

Honors and awards

2018 Graduate School of Chinese Academy of Agricultural Science scholarship
2020 Excellent mid-term assessment award, LVRI, GSCAAS
2021 Excellent presentation award (Foreign category), LVRI, GSCAAS

Research interests

I am a dedicated viral immunologist with a profound interest in unraveling the cell signaling pathways that govern hyperinflammation. My research focuses on understanding the molecular mechanisms underlying inflammation and the inflammasome, particularly on their roles in the context of viral pathogens and cancer.

As a member of Dr. Nichols’s team, I am committed to advancing our understanding of these complex biological processes and contributing to the development of innovative therapeutic strategies for the treatment of hyperinflammatory disorders, immunodeficiency, and cancer. With a passion for scientific discovery and a collaborative spirit, I aspire to make meaningful contributions that drive progress in combating these critical health challenges.

Contact Information

Sk Mohiuddin Choudhury, DVM, MS, PhD Department of Oncology MS 343, Room D4022.03 St. Jude Children’s Research Hospital 262 Danny Thomas Place Memphis, TN 38105-3678

Selected Publications

Choudhury SM, Sarkar R, Karki R, Kanneganti TD. A comparative study of apoptosis, pyroptosis, necroptosis, and PANoptosis components in mouse and human cells. PLoS One 2024 Feb 27;19(2):e0299577. doi: 10.1371/journal.pone.0299577. PMID: 38412164; PMCID: PMC10898734.

Sarkar R, Choudhury SM, Kanneganti TD. Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis. J Biol Chem 2024 Sep;300(9):107676. doi: 10.1016/j.jbc.2024.107676. Epub 2024 Aug 14. PMID: 39151726; PMCID: PMC11418131. Equal contribution.

Choudhury SM, Ma X, Li Y, Nian X, Luo Z, Ma Y, Zhu Z, Yang F, Cao W, Zheng H. FMDV Leader Protein Interacts with the NACHT and LRR Domains of NLRP3 to Promote IL-1β Production. Viruses 2021 Dec 23;14(1):22. doi: 10.3390/v14010022. PMID: 35062226; PMCID: PMC8778935.

Choudhury SM, Ma X, Abdullah SW, Zheng H. Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses. J Inflamm Res 2021 Mar 26;14:1145-1163. doi: 10.2147/JIR.S295706. PMID: 33814921; PMCID: PMC8009543.

Choudhury SM, Ma X, Zeng Z, Luo Z, Li Y, Nian X, Ma Y, Shi Z, Song R, Zhu Z, Cao W, Pei J, Zheng H. Senecavirus a 3D Interacts with NLRP3 to Induce IL-1β Production by Activating NF-κB and Ion Channel Signals. Microbiol Spectr 2022 Apr 27;10(2):e0209721. doi: 10.1128/spectrum.02097-21. Epub 2022 Mar 7. PMID: 35254168; PMCID: PMC9045273.

Choudhury SM, Ma X, Dang W, Li Y, Zheng H. Recent Development of Ruminant Vaccine Against Viral Diseases. Front Vet Sci 2021 Nov 3;8:697194. doi: 10.3389/fvets.2021.697194. PMID: 34805327; PMCID: PMC8595237.

Yang B, Zhang X, Zhang D, Hou J, Xu G, Sheng C, Choudhury SM, Zhu Z, Li D, Zhang K, Zheng H, Liu X. Molecular Mechanisms of Immune Escape for Foot-and-Mouth Disease Virus. Pathogens 2020 Sep 4;9(9):729. doi: 10.3390/pathogens9090729. PMID: 32899635; PMCID: PMC7558374.

Ma X, Zhang K, Luo Z, Nian X, Choudhury SM, Zhu Z, Song R, Pei J, Huo Y, Li Y, Yang F, Cao W, Liu H, Liu X, Zheng H. FMDV 3A Antagonizes the Effect of ANXA1 to Positively Modulate Viral Replication. J Virol 2022 Jun 22;96(12):e0031722. doi: 10.1128/jvi.00317-22. Epub 2022 May 23. PMID: 35604142; PMCID: PMC9215249.

Ma X, Luo Z, Song R, Nian X, Choudhury SM, Ru Y, Yang F, Zhang Y, Zeng Z, Cao W, Pei J, Liu X, Zheng H. The Foot-and-Mouth Disease Virus Lb Protease Cleaves Intracellular Transcription Factors STAT1 and STAT2 to Antagonize IFN-β-Induced Signaling. J Immunol 2023 Feb 1;210(3):283-296. doi: 10.4049/jimmunol.2101042. PMID: 36548461; PMCID: PMC9842942.

Choudhury SM, Mohammad Musharraf Uddin Bhuiyan, Mohammad Moshiur Rahman, Md. Masudur Rahman, Md. Newaz Sharif, Jayonta Bhattacharjee, Farida Yeasmin Bari, and Nasrin Sultana Juyena. Comparison between Two Cryo-devices for Vitrification of Immature Oocytes of Indigenous Zebu Cows in Bangladesh. Journal of Embryo Transfer 2017; 32(4): 311-317. https://doi.org/10.12750/JET.2017.32.4.311

Last update: December 2024