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Zhaoming Wang, PhD
Zhaoming Wang, PhD

Education

BSc - East China Normal University, Shanghai, China
MSc - University of Illinois, Chicago, IL
PhD - George Mason University, Manassas, VA

Research Interests

  • Genetic epidemiology of cancers (primary, subsequent)
  • Biomarkers for late effects of childhood cancer survivors
  • Omics-based precision preventive medicine

Current Research

  • NIH/NCI, R01CA283333, Genetic Pleiotropy Across Pediatric Cancers and Cancer-Related Outcomes, Principal Investigator
  • NIH/NCI, R01CA279520, Trajectory of Epigenetic Aging and Health Outcomes in Childhood Cancer Survivors, Principal Investigator
  • NIH/NCI, R01CA290112, Genomics-based Mechanistic Investigation of Cancer-treatment Related Cardiometabolic Toxicity among Survivors of Childhood Cancer, Principal Investigator
  • V-Foundation for Cancer Research, DT2020-014, Social Epigenetic Pathways Towards Health Disparity in Adult Survivors of Childhood Cancer, Principal Investigator

Selected Publications

Chen C, Plonski NM, Dong Q, Song N, Zhang X, Parikh HM, Finch ER, Easton J, Mulder HL, Walker E, Neale G, Pan Y, Li Q, Zhang J, Krull KR, Robison LL, Armstrong GT, Yasui Y, Ness KK, Hudson MM, Wang H, Huang IC, Wang Z. Race/ethnicity, socioeconomic factors and epigenetic age acceleration in childhood cancer survivors. JAMA Netw Open 2024 (in press). Role: Senior & corresponding author.

Plonski NM, Pan Y, Chen C, Dong Q, Zhang X, Song N, Shelton K, Easton J, Mulder H, Zhang J, Neale G, Walker E, Wang H, Webster R, Brinkman T, Krull KR, Armstrong GT, Ness KK, Hudson MM, Li Q, Huang IC, Wang Z. Health-related quality of life and DNA methylation-based aging biomarkers among survivors of childhood cancer. Role: Senior & corresponding author. J Natl Cancer Inst Mar 5:djae046, 2024 (Epub). PMID: 38445706. Role: Senior & corresponding author

Chen C, Qin N, Wang M, Dong Q, Tithi SS, Hui Y, Chen W, Wu G, Kennetz D, Edmonson MN, Rusch MC, Thrasher A, Easton J, Mulder HL, Song N, Plonski NM, Shelton K, Im C, Ehrhardt MJ, Nichols KE, Leisenring WM, Stratton KL, Howell R, Yasui Y, Bhatia S, Armstrong GT, Ness KK, Hudson MM, Zhang J, Wang H, Srivastava DK, Robison LL, Wang Z. Cancer germline predisposing variants and late mortality from subsequent malignant neoplasms among long-term childhood cancer survivors: A report from the St. Jude Lifetime Cohort and the Childhood Cancer Survivor Study. Lancet Oncol Oct;24(10):1147-1156, 2023. PMID: 37797633. Role: Senior & corresponding author

Plonski NM, Chen C, Dong Q, Song N, Shelton K, Finch E, Easton J, Mulder H, Zhang J, Neale G, Walker E, Wang H, Krull KR, Ness KK, Hudson MM, Robison LL, Li Q, Williams AM, Wang Z. Epigenetic age in peripheral blood among children, adolescent, and adult survivors of childhood cancer. JAMA Netw Open Apr 3;6(4):e2310325, 2023. PMID: 37115548. Role: Senior & corresponding author

Chen C, Song N, Dong Q, Sun X, Mulder HL, Easton J, Zhang J, Yasui Y, Bhatia S, Armstrong GT, Wang H, Ness KK, Hudson MM, Robison LL, Wang Z. Association of Single-Nucleotide Variants in the Human Leukocyte Antigen and Other Loci with Childhood Hodgkin Lymphoma. JAMA Netw Open Aug 1;5(8):e2225647, 2022. PMID: 35939300. Role: Senior author, corresponding author

Dong Q, Song N, Qin N, Chen C, Li Z, Sun X, Easton J, Mulder H, Plyler E, Neale G, Walker E, Li Q, Ma X, Chen X, Huang IC, Yasui Y, Ness KK, Zhang J, Hudson MM, Robison LL, Wang Z. Genome-wide association studies identify novel genetic loci for epigenetic age acceleration among survivors of childhood cancer. Genome Med Mar 22;14(1):32, 2022. PMID: 35313970. Role: Senior author, corresponding author

Song N, Dong Q, Chen C, Li Q, Mulder H, Plyler E, Easton J, Walker E, Olson S, Neale G, Krull KR, Srivastava DK, Ness KK, Zhang J, Hudson MM, Robison LL, Huang IC, Wang Z. Social-epigenetic mediators for racial disparities in pulmonary impairment among childhood cancer survivors. Letter to the Editor. Cancer Commun (Lond) Oct 18 (Epub), 2022. PMID: 36256508. Role: Senior author, corresponding author

Song N, Sim JA, Dong Q, Zheng Y, Hou L, Li Z, Hsu CW, Pan H, Mulder H, Easton J, Walker E, Neale G, Wilson CL, Ness KK, Krull KR, Srivastava DK, Yasui Y, Zhang J, Hudson MM, Robison LL, Huang IC, Wang Z. Blood DNA methylation signatures are associated with social determinants of health among survivors of childhood cancer. Epigenetics Feb 2;1-15. PMID: 35109748. Role: Senior author, corresponding author

Song N, Liu Q, Wilson CL, Sapkota Y, Ehrhardt MJ, Gibson TM, Morton LM, Chanock SJ, Neglia JP, Arnold MA, Michael JR, Gout AM, Mulder HL, Easton J, Bhatia S, Armstrong GT, Zhang J, Delaney A, Hudson MM, Robison LL, Yasui Y, Wang Z. Polygenic Risk Score Improves Risk Stratification and Prediction of Subsequent Thyroid Cancer after Childhood Cancer. Cancer Epidemiol Biomarkers Prev Nov;30(11):2096-2104, 2021. PubMed PMID: 34465587. Role: Senior author, corresponding author

Qin N, Li Z, Song N, Wilson CL, Easton J, Mulder H, Plyler H, Neale G, Walker E, Zhou x, Pan H, Hudson MM, Yasui Y, Robison L, Zhang J, Ness KK, Wang Z. Epigenetic age acceleration and chronic health conditions among adult survivors of childhood cancer. J Natl Cancer Inst May 4;113(5):597-605, 2021. PubMed PMID: 32970815. Role: Senior author, corresponding author

Song N, Hsu w, Pan H, Zheng Y, Hou L, Sim JA, Li Z, Mulder H, Easton J, Walker E, Neale G, Wilson CL, Ness KK, Krull KR, Srivastava DK, Yasui Y, Zhang J, Hudson MM, Robison LL, Huang IC, Wang Z. Persistent variations of blood DNA methylation associated with treatment exposures and risk for cardiometabolic outcomes in long-term survivors of childhood cancer in the St. Jude Lifetime Cohort. Genome Med Apr 6;13(1):53, 2021. PubMed PMID: 33823916. Role: Senior author, corresponding author

Song N, Li Z, Qin N, Howell CR, Wilson CL, Easton J, Mulder HL, Edmonson MN, Rusch MC, Zhang J, Hudson MM, Yasui Y, Robison LL, Ness KK, Wang Z. Shortened leukocyte telomere length associates with an increased prevalence of chronic health conditions among survivors of childhood cancer: A report from the St. Jude Lifetime Cohort. Clin Cancer Res May 15;26(10):2362-2371, 2020. PubMed PMID: 31969337. Role: Senior author, corresponding author

Wang Z, Rice SV, Chang TC, Liu Y, Liu Q, Qin N, Putnam DK, Shelton K, Lanctot JQ, Wilson CL, Ness KK, Rusch MC, Edmonson MN, Wu G, Easton J, Kesserwan CA, Downing JR, Chen X, Nichols KE, Yasui Y, Robison LL, Zhang J. Molecular mechanism of telomere length dynamics and its prognostic value in pediatric cancers. J Natl Cancer Inst Jul 1;112(7):756-764, 2020. PubMed PMID: 31647544. Role: First author, corresponding author

Wang Z, Wilson CL, Armstrong GT, Hudson MM, Zhang J, Nichols KE, Robison LL. Association of Germline BRCA2 mutations with the risk of pediatric or adolescent non-Hodgkin lymphoma. JAMA Oncol Jul 25;5(9):1362-1364, 2019. PubMed PMID: 31343663. Role: First author, corresponding author

Wang Z, Liu Q, Wilson CL, Easton J, Mulder H, Chang TC, Rusch MC, Edmonson MN, Rice SV, Ehrhardt MJ, Howell RM, Kesserwan CA, Wu G, Nichols KE, Downing JR, Hudson MM, Zhang J, Yasui Y, Robison LL. Polygenic determinants for subsequent breast cancer risk in survivors of childhood cancer: The St. Jude Lifetime Cohort Study (SJLIFE). Clin Cancer Res Dec 15;24(24):6230-6235, 2018. PubMed PMID: 30366939. Role: First author, corresponding author

Wang Z, Wilson CL, Easton J, Thrasher A, Mulder H, Liu Q, Hedges DJ, Wang S, Rusch MC, Edmonson MN, Levy S, Lanctot JQ, Caron E, Shelton K, Currie K, Lear M, Patel A, Rosencrance C, Shao Y, Vadodaria B, Yergeau D, Sapkota Y, Brooke RJ, Moon W, Rampersaud E, Ma X, Chang TC, Rice SV, Pepper C, Zhou X, Chen X, Chen W, Jones A, Boone B, Ehrhardt MJ, Krasin MJ, Howell RM, Phillips NS, Lewis C, Srivastava D, Pui CH, Kesserwan CA, Wu G, Nichols KE, Downing JR, Hudson MM, Yasui Y, Robison LL, Zhang J. Genetic risk for subsequent neoplasms among long-term survivors of childhood cancer. J Clin Oncol Jul 10;36(20):2078-2087, 2018 PubMed PMID: 29847298. Role: First author

Wang Z, McGlynn KA, Rajpert-De Meyts E, Bishop DT, Chung CC, Dalgaard MD, Greene MH, Gupta R, Grotmol T, Haugen TB, Karlsson R, Litchfield K, Mitra N, Nielsen K, Pyle LC, Schwartz SM, Thorsson V, Vardhanabhuti S, Wiklund F, Turnbull C, Chanock SJ, Kanetsky PA, Nathanson KL; Testicular Cancer Consortium. Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. Nat Genet Jun 17;49(7):1141-1147, 2017. PubMed PMID: 28604732. Role: First author

Last update: May 2024

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