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Octavio Ramilo, MD
Octavio Ramilo, MD

Octavio Ramilo, MD

Member, St. Jude Faculty

  • Chair, Department of Infectious Diseases

Departments

Education

MD – Facultad de Medicina, Universidad Completense, Madrid, Spain
Residency (Pediatrics) - Universidad Completense, Madrid, Spain
Fellowship (Pediatric Infectious Diseases) – University of Texas Southwestern Medical Center, Dallas, Texas
Postdoctoral Research Training (Immunology) - University of Texas Southwestern Medical Center, Dallas, Texas

Honors and Awards

  • 1983  Award Real Academia de Medicina (Spain) for Scholar Achievement
  • 2016  Caroline B. Hall Lectureship, Pediatric Infectious Disease Society, IDWeek 2016

Research Interests

  • Viral respiratory infections
  • Early life immunity
  • Application of systems analysis tools in the clinical setting

Selected Publications

Mahajan P, VanBuren JM, Tzimenatos L, Cruz AT, Vitale M, Powell EC, Leetch AN, Pickett ML, Brayer A, Nigrovic LE, Dayan PS, Atabaki SM, Ruddy RM, Rogers AJ, Greenberg R, Alpern ER, Tunik MG, Saunders M, Muenzer J, Levine DA, Hoyle JD, Lillis KG, Gattu R, Crain EF, Borgialli D, Bonsu B, Blumberg S, Anders J, Roosevelt G, Browne LR, Cohen DM, Linakis JG, Jaffe DM, Bennett JE, Schnadower D, Park G, Mistry RD, Glissmeyer EW, Cator A, Bogie A, Quayle KS, Ellison A, Balamuth F, Richards R, Ramilo O, Kuppermann N. Pediatric Emergency Care Applied Research Network (PECARN). Serious Bacterial Infections in Young Febrile Infants with Positive Urinalysis Results. Pediatrics Oct 1;150(4):e2021055633, 2022. PMID: 36097858

Taveras J, Garcia-Maurino C, Moore-Clingenpeel M, Xu Z, Mertz S, Ye F, Chen P, Cohen SH, Cohen D, Peeples ME, Ramilo O, Mejias A. Type-III Interferons, Viral Loads, Age, and Disease Severity in Young Children with Respiratory Syncytial Virus Infection. J infect Dis Dec 28;227(1):61-70, 2022. PMID: 36200173

Quintero AM, Eisner M, Sayegh R, Wright T, Ramilo O, Leber AL, Wang H, Mejias A. Differences in clinical presentations and disease severity in children and adolescents according to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variant. Emerg Infect Dis 2022 (in press).

Halabi K, Wang H, Leber A.L, Sanchez P.J, Ramilo O, Mejias A. Respiratory Syncytial Virus and SARS-CoV-2 Coinfections in Children. Pediatr Pulmonol Dec;57(12):3158-3160, 2022 PMID: 35997032

Mazur NI, Terstappen J, Baral R, Bardají A, Beutels P, Buchholz UJ, Cohen S, Crowe JE Jr, Cutland CL, Eckert L, Feikin D, Fitzpatrick T, Fong Y, Graham B, Heikkinen T, Higgins D, Hirve S, Klugman K, Kragten-Tabatabaie L, Lemey P, Libster R, Löwensteyn Y, Mejias A, Munoz FM, Munywoki PK, Mwananyanda L, Nair H, Nunes MC, Ramilo O, Richmond P, Ruckwardt TJ, Sande C, Srikantiah P, Thacker N, Waldstein KA, Weinberger D, Wildenbeest J, Wiseman D, Zar HJ, Zambon M, Bont L. Respiratory Syncytial Virus Prevention within Reach: The Vaccine and Monoclonal Antibody Landscape. Lancet Infect Dis 2022 (in press). PMID: 35952703

Palacios S, Krivchenia K, Eisner M, Young B, Ramilo O, Mejias A, Lee S, Koop B. Long-term pulmonary sequelae in adolescents post-SARS-CoV-2 infection. Pediatr Pulmonol 2022 (in press). PMID: 35775163

Arias-Bravo G, Valderram G, Inostroza J, Tapia C, Toro-Ascuy D, Ramilo O, Orellana P, Cifuentes-Muñoz N, Zorondo-Rodríguez F, Mejias A, Fuenzalida LF. Overnutrition, nasopharyngeal pathogenic bacteria and proinflammatory cytokines in infants with viral lower respiratory tract infections. Int J Environ Res Public Health 19 (14): 8781, 2022. PMID: 35886632

Rodriguez-Ferandez R, Gonzalez-Sanchez M.I., Perez-Moreno J, Gonzalez-Martinez F, de la Mata Navazo S, Mejias A, Ramilo O. Age and Respiratory Syncytial Virus Etiology in Bronchiolitis Clinical Outcomes. J Allergy Clin Immunol Global 1(3): 91-98, 2022. doi.org/10.1016/j.jacig.2022.05.005

Bline K, Andrews A, Mertz S, Ye F, Best V, Sayegh R, Tomatis-Souverbielle C, Quintero AM, Maynard Z, Mejias A, Ramilo O. Myeloid-derived suppressor cells and clinical outcomes in children with COVID-19. Front Pediatr 10:893045, 2022. PMID: 35733812

Yun KW, Wallihan R, Desai A, Alter S, Ambroggio L, Cohen DM, El-Assal O, Marzec S, Florin TA, Keaton M, Shah SS, Ruddy RM, Sharpe S, Leber AL, Everhart K, Mejias A, Ramilo O. Clinical Characteristics and Etiology of Community-Acquired Pneumonia in US Children, 2015-2018. Ped Infect Dis J 41 (5):381-87, 2022. PMID: 35143427

Glowinski R, Mejias A, Ramilo O. New preventive strategies for respiratory syncytial virus infection in children. Curr Opin Virol Dec; 51:216-223, 2021. PMID: 3478110

Martinón-Torres F, García-Sastre A, Pollard AJ, Martín C, Osterhaus A, Ladhani SN, Ramilo O, Gómez Rial J, Salas A, Bosch FX, Martinón-Torres M, Mina MJ, Cherry J. TIPICO XI: report of the first series and podcast on infectious diseases and vaccines (aTIPICO). Hum Vaccin Immunother Nov 11;1-29, 2021. PMID: 34762551

Navarro Alonso JA, Bont LJ, Bozzola E, Herting E, Lega F, Mader S, Nunes MC, Ramilo O, Valiotis G, Olivier CW, Yates A, Faust SN. RSV: perspectives to strengthen the need for protection in all infants. Emerg Themes Epidemiol Oct 21;18(1):15, 2021. PMID: 34674730. PMCID: PMC8529565

Mertz C, Glowinski R, Cohen SH, Mertz S, Ye F, Hall MW, Peeples ME, King T, Wang H, Leber AL, Sanchez PJ, Ramilo O, Mejias A. SARS-CoV-2 RNAemia and clinical outcomes in children with COVID-19. J Infect Dis Oct 7; jiab491, 2021. PMID: 34618885. doi: 10.1093/infdis/jiab491

Mejias A, Cohen S, Glowinski R, Ramilo O. Host transcriptional signatures as predictive markers of infection in children. Curr Opin Infect Dis Oct 1;34(5):552-558, 2021. PMID 34232136. PMCID: PMC8446306

Diaz-Diaz A, Bunsow E, Garcia-Maurino C, Moore-Clingenpeel M, Naples J, Juergensen A, Mertz S, Wang H, Leber AL, Gern J, Hall MW, Cohen DM, Ramilo O, Mejias A. Nasopharyngeal Codetection of H. influenzae and S. pneumoniae and Respiratory Syncytial Virus Disease Outcomes in Children. J Infect Dis Sep 20; jiab481, 2021. PMID:34543409. doi: 10.1093/infdis/jiab481

Altman MC, Rinchai D, Baldwin N, Toufiq M, Whalen E, Garand M, Syed Ahamed Kabeer B, Alfaki M, Presnell SR, Khaenam P, Ayllón-Benítez A, Mougin F, Thébault P, Chiche L, Jourde-Chiche N, Phillips JT, Klintmalm G, O'Garra A, Berry M, Bloom C, Wilkinson RJ, Graham CM, Lipman M, Lertmemongkolchai G, Bedognetti D, Thiebaut R, Kheradmand F, Mejias A, Ramilo O, Palucka K, Pascual V, Banchereau J, Chaussabel D. Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data. Nat Commun Jul 19;12(1):4385, 2021. PMID 34282143. PMCID:  PMC8289976

Giacomelli Cao R, Christian L, Xu Z, Jaramillo L, Smith B, Karlsson EA, Schultz-Cherry S, Mejias A, Ramilo O. Early changes in interferon gene expression and antibody responses following influenza vaccination in pregnant women. J Infect Dis Jul 1; jiab345, 2021. PMID: 34197595 doi: 10.1093/infdis/jiab345

Lanata MM, Wang H, Everhart K, Moore-Clingenpeel M, Ramilo O, Leber A. Macrolide-Resistant Mycoplasma pneumoniae Infections in Children, Ohio, USA. Emerg Infect Dis Jun;27(6):1588-1597, 2021. PMID: 34013867. PMCID: PMC8153876

Mejias A, Brenes-Chacon H, Garcia-Mauriño C, Moore-Clingenpeel M, Ramilo O. Clinical Disease Severity Scores and Viral Loads in Children With Respiratory Syncytial Virus Infection. Clin Infect Dis Jun 15;72(12):e1160-e1162, 2021. PMID: 33215632 PMCID: PMC8204790

Koivisto K, Nieminen T, Mejias A, Capella C, Ye F, Mertz S, Peeples M, Ramilo O, Saxén H. RSV Specific Antibodies in Pregnant Women and Subsequent Risk of RSV Hospitalization in Young Infants. J Infect Dis Jun 15;jiab315, 2021. PMID:34129040. doi: 10.1093/infdis/jiab315

Rodriguez-Fernandez R, Mejias A, Ramilo O. Monoclonal Antibodies for Prevention of Respiratory Syncytial Virus Infection. Pediatr Infect Dis J May 1;40(5S):S35-S39, 2021. PMID: 34042909

Rodriguez-Fernandez R, Gonzalez-Martinez F, Gonzalez-Sanchez MI, Heraandez-Sanpelayo T, Jimenez JL, Munoz-Fernandez MA, Garcia-Martos C, Mejias A, Ramilo O. Longitudinal plasma cytokine concentrations and recurrent wheezing after RSV bronchiolitis. Cytokine Apr;140:1554343, 2021. PMID: 33513527

King T, Mejias A, Ramilo O, Peeples ME. The larger attachment glycoprotein of respiratory syncytial virus produced in primary human bronchial epithelial cultures reduces infectivity for cell lines. PLoS Pathog Apr 8;17(4):e1009469, 2021. PMID: 33831114. PMC 8057581

Lu M, Dravid P, Zhang Y, Trivedi S, Li A, Harder O, Kc M, Chaiwatpongsakorn S, Zani A, Kenney A, Zeng C, Cai C, Ye C, Liang X, Shimamura M, Liu SL, Mejias A, Ramilo O, Boyaka PN, Qiu J, Martinez-Sobrido L, Yount JS, Peeples ME, Kapoor A, Niewiesk S, Li J. A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike. Proc Natl Acad Sci USA 2021 Mar 23;118(12):e2026153118, 2021. PMID: 33688034. PMC 8000430

Sanchez-Codez MI, Moyer K, Benavente-Fernández I, Leber AL, Ramilo O, Mejias A. Viral Loads and Disease Severity in Children with Rhinovirus-Associated Illnesses. Viruses Feb 13;13(2):295, 2021. PMID: 33668603. PMC 7918889

Tomatis Souverbielle C, Wang H, Feister J, Campbell J, Medoro A, Mejias A, Ramilo O, Pietropaolo D, Salamon D, Leber A, Erdem G. Year-Round, Routine Testing of Multiple Body Site Specimens for Human Parechovirus in Young Febrile Infants. J Pediatr Feb;229:216-222.e.2, 2021. PMID: 33045237 PMCID: PMC7546655

Brenes-Chacon H, Garcia-Mauriño C, Moore-Clingenpeel M, Mertz S, Ye F, Cohen DM, Ramilo O, Mejias A. Age-dependent Interactions Among Clinical Characteristics, Viral Loads and Disease Severity in Young Children With Respiratory Syncytial Virus Infection. Pediatr Infect Dis J Feb 1;40(2):116-122, 2021. PMID: 33433159

Jenkins T, Wang R, Harder O, Xue M, Chen P, Corry J, Walker C, Teng M, Mejias A, Ramilo O, Niewiesk S, Li J, Peeples ME. A Novel Live Attenuated Respiratory Syncytial Virus Vaccine Candidate with Mutations in the L Protein SAM Binding Site and the G Protein Cleavage Site Is Protective in Cotton Rats and a Rhesus Macaque. J Virol Jan 13;95(3):e01568-20, 2021. doi: 10.1128/JVI.01568-20. PMID: 33177201

Last update: March 2023

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