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Carmen A. Perez, MD, PhD
Carmen A. Perez, MD, PhD

Carmen A. Perez, MD, PhD

Associate Member, St. Jude Faculty

Departments

Education

Residency – Memorial Sloan-Kettering Cancer Center, New York, NY
Postdoctoral Training – Vanderbilt University Medical Center, Nashville, TN
MD – Vanderbilt University School of Medicine, Nashville, TN
PhD (Biochemistry) – Vanderbilt University Medical Center, Nashville, TN
BS – University of Puerto Rico, Mayaguez, PR

Professional Memberships

  • American Society for Therapeutic Radiation and Oncology (ASTRO)

Research Interests

  • Radiation-induced toxicities and risk mitigation in pediatric cancers
  • Radiation-induced second malignancies
  • Ependymoma

Selected Publications

Purswani JM, Bigham Z, Adotama P, Oh C, Xiao J, Maisonet O, Teruel JR, Gutierrez D, Tattersall IW, Perez CA, Gerber NK. Risk of Radiation Dermatitis in Patients With Skin of Color Who Undergo Radiation to the Breast or Chest Wall With and Without Regional Nodal Irradiation. Int J Radiat Oncol Biol Phys 2023 Oct 1;117(2):468-478. doi: 10.1016/j.ijrobp.2023.04.006. Epub 2023 Apr 14. PMID: 37060928.

Gao Y, Perez CA, Chhor C, Heller SL. Breast Cancer Screening in Survivors of Childhood Cancer. Radiographics 2023 Apr;43(4):e220155. doi: 10.1148/rg.220155. PMID: 36927127.

Hardy-Abeloos C, Xiao J, Oh C, Barbee D, Perez CA, Oratz R, Schnabel F, Axelrod D, Guth A, Braunstein LZ, Khan A, Choi JI, Gerber N.  Early effectiveness and toxicity outcomes of reirradiation after breast conserving surgery for recurrent or new primary breast cancer.  Breast Cancer Res Treat 2023:198(1):43-51.   PubMed PMID: 26604352

Purswani JM, Nwankwo C, Adotama P, Gutierrez D, Perez CA, Tattersall IW, Gerber NK.  Radiation-induced skin changes after breast or chest wall irradiation in patients with breast cancer and skin of color: A systematic review.  Clin Breast Cancer  2023:23(1):1-14.  PubMed PMID: 36335037

Purswani JM, Oh C, Teruel JR, Xiao J, Barbee DL, Maisonet OG, Perez CA, Huppert NE, Gerber NK. Definitive Radiation With Nodal Boost for Patients With Locally Advanced Breast Cancer. Pract Radiat Oncol 2023 Mar-Apr;13(2):e103-e114. doi: 10.1016/j.prro.2022.10.012. Epub 2022 Nov 23. PMID: 36435389.

Hardy-Abeloos C, Xiao J, Oh C, Barbee D, Perez CA, Oratz R, Schnabel F, Axelrod D, Guth A, Braunstein LZ, Khan A, Choi JI, Gerber N. Early effectiveness and toxicity outcomes of reirradiation after breast conserving surgery for recurrent or new primary breast cancer. Breast Cancer Res Treat 2023 Feb;198(1):43-51. doi: 10.1007/s10549-022-06853-4. Epub 2023 Jan 5. PMID: 36604352.

Purswani JM, Nwankwo C, Adotama P, Gutierrez D, Perez CA, Tattersall IW, Gerber NK. Radiation-induced skin changes after breast or chest wall irradiation in patients with breast cancer and skin of color: a systematic review. Clin Breast Cancer 2023 Jan;23(1):1-14. doi: 10.1016/j.clbc.2022.10.002. Epub 2022 Oct 8. PMID: 36335037. 

Purswani JM, Hardy-Abeloos C, Perez CA, Kwa MJ, Chadha M, Gerber NK. Radiation in Early-Stage Breast Cancer: Moving beyond an All or Nothing Approach. Curr Oncol 2022 Dec 23;30(1):184-195. doi: 10.3390/curroncol30010015. PMID: 36661664; PMCID: PMC9858412.

Shah BA, Xiao J, Oh C, Taneja S, Barbee D, Maisonet O, Huppert N, Perez CA, Gerber NK. Five-Fraction Prone Accelerated Partial Breast Irradiation: Long-Term Oncologic, Dosimetric, and Cosmetic Outcome. Pract Radiat Oncol 2022 Mar-Apr;12(2):106-112. doi: 10.1016/j.prro.2021.08.009. Epub 2021 Aug 30. PMID: 34474168.

Gerber NK, Yan SX, Levinson BA, Perez CA, Das IJ, Maisonet OG, Huppert N, No DK, Kelley J, Mistry N, Hitchen CJ, Goldberg JD. A Prospective Trial to Compare Deep Inspiratory Breath Hold With Prone Breast Irradiation. Pract Radiat Oncol 2020 Sep-Oct;10(5):330-338. doi: 10.1016/j.prro.2020.01.001. Epub 2020 Feb 1. PMID: 32014615.

Shaikh F, Tam M, Taneja S, Huppert N, McCarthy A, Hitchen C, Maisonet O, Perez CA, Barbee D, Gerber NK. Whole breast irradiation with high tangents in the prone position. J Radiat Oncol 2020 9(3-4):147-154. DOI https://doi.org/10.1007/s13566-020-00433-z

Yan SX, Maisonet OG, Perez CA, Huppert N, Hitchen CJ, Das IJ, Gerber NK. Radiation effect on late cardiopulmonary toxicity: An analysis comparing supine DIBH versus prone techniques for breast treatment. Breast J 2020 May;26(5):897-903. doi: 10.1111/tbj.13742. Epub 2020 Jan 7. PMID: 31912595.

Purswani JM, Shaikh F, Wu SP, Kim JC, Schnabel F, Huppert N, Perez CA, Gerber NK. Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence. World J Clin Oncol 2020 Jan 24;11(1):20-30. doi: 10.5306/wjco.v11.i1.20. PMID: 31976307; PMCID: PMC6935692.

Mailhot Vega RB Jr, Barbee D, Talcott W, Duckworth T, Shah BA, Ishaq OF, Small C, Yeung AR, Perez CA, Schiff PB, Ginsburg O, Small W, Abdel-Wahab M, Bardales GS, Harkenrider M. Cost in perspective: direct assessment of American market acceptability of Co-60 in gynecologic high-dose-rate brachytherapy and contrast with experience abroad. J Contemp Brachytherapy 2018 Dec;10(6):503-509. doi: 10.5114/jcb.2018.79928. Epub 2018 Dec 28. PMID: 30662472; PMCID: PMC6335552.

Shaikh F, Chew J, Hochman T, Purswani J, Maisonet O, Peat E, Huppert N, Cooper BT, Tam M, Goldberg JD, Perez CA, Formenti SC, Gerber NK. Hypofractionated Whole-Breast Irradiation in Women Less Than 50 Years Old Treated on 4 Prospective Protocols. Int J Radiat Oncol Biol Phys 2018 Aug 1;101(5):1159-1167. doi: 10.1016/j.ijrobp.2018.04.034. Epub 2018 Apr 19. PMID: 29859789.

Katz LM, Perez CA, Gerber NK, Purswani J, McCarthy A, Das IJ. Skin recurrence in the radiation treatment of breast cancer. Adv Radiat Oncol.2018 May 7;3(3):458-462. doi: 10.1016/j.adro.2018.04.014. PMID: 30202813; PMCID: PMC6128028.

McClelland S 3rd, Perez CA. The pervasive crisis of diminishing radiation therapy access for vulnerable populations in the United States-part 3: Hispanic-American patients. Adv Radiat Oncol 2017 Dec 29;3(2):93-99. doi: 10.1016/j.adro.2017.12.003. PMID: 29904731; PMCID: PMC6000066.

Wu SP, Tam M, Vega RM, Perez CA, Gerber NK. Effect of Breast Irradiation on Cardiac Disease in Women Enrolled in BCIRG-001 at 10-Year Follow-Up. Int J Radiat Oncol Biol Phys 2017 Nov 1;99(3):541-548. doi: 10.1016/j.ijrobp.2017.06.018. Epub 2017 Jun 23. PMID: 29280448.

Wu AJ, Gillis A, Foster A, Woo K, Zhang Z, Gelblum DY, Downey RJ, Rosenzweig KE, Ong L, Perez CA, Pietanza MC, Krug L, Rudin CM, Rimner A. Patterns of failure in limited-stage small cell lung cancer: Implications of TNM stage for prophylactic cranial irradiation. Radiother Oncol 2017 Oct;125(1):130-135. doi: 10.1016/j.radonc.2017.07.019. Epub 2017 Aug 1. PMID: 28778345; PMCID: PMC5643234.

Lok BH, Ma J, Foster A, Perez CA, Shi W, Zhang Z, Li BT, Rudin CM, Rimner A, Wu AJ. Factors influencing the utilization of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer. Adv Radiat Oncol 2017 Aug 8;2(4):548-554. doi: 10.1016/j.adro.2017.08.001. PMID: 29204521; PMCID: PMC5707415.

Mailhot Vega R, Talcott W, Ishaq O, Cohen P, Small CJ, Duckworth T, Sarria Bardales G, Perez CA, Schiff PB, Small W Jr, Harkenrider MM. A national survey of HDR source knowledge among practicing radiation oncologists and residents: Establishing a willingness-to-pay threshold for cobalt-60 usage. Brachytherapy 2017 Jul-Aug;16(4):910-915. doi: 10.1016/j.brachy.2017.04.235. Epub 2017 May 15. PMID: 28522118.

Muresan H, Lam G, Cooper BT, Perez CA, Hazen A, Levine JP, Saadeh PB, Choi M, Karp NS, Ceradini DJ. Impact of Evolving Radiation Therapy Techniques on Implant-Based Breast Reconstruction. Plast Reconstr Surg 2017 Jun;139(6):1232e-1239e. doi: 10.1097/PRS.0000000000003341. PMID: 28538549.

Tam MM, Wu SP, Perez CA, Gerber NK. The effect of post-mastectomy radiation in women with one to three positive nodes enrolled on the control arm of BCIRG-005 at ten year follow-up. Radiother Oncol 2017 Apr;123(1):10-14. doi: 10.1016/j.radonc.2017.03.001. Epub 2017 Mar 22. PMID: 28341062.

Mailhot Vega RB, Ishaq O, Raldow A, Perez CA, Jimenez R, Scherrer-Crosbie M, Bussiere M, Taghian A, Sher DJ, MacDonald SM. Establishing Cost-Effective Allocation of Proton Therapy for Breast Irradiation. Int J Radiat Oncol Biol Phys 2016 May 1;95(1):11-18. doi: 10.1016/j.ijrobp.2016.02.031. Epub 2016 Mar 19. PMID: 27084617.

Ong LT, Dunphy M, Foster A, Woo KM, Zhang Z, Perez CA, Pietanza CM, Rosenzweig KE, Gelblum DY, Rimner A, Wu AJ. Prognostic Value of Preradiotherapy (18)F-FDG PET/CT Volumetrics in Limited-Stage Small-Cell Lung Cancer. Clin Lung Cancer 2016 May;17(3):184-8. doi: 10.1016/j.cllc.2015.07.004. Epub 2015 Aug 3. PMID: 26320828; PMCID: PMC4740253.

Perez CA, Zumsteg ZS, Gupta G, Morrow M, Arnold B, Patil SM, Traina TA, Robson ME, Wen YH, McCormick B, Powell SN, Ho AY. Black race as a prognostic factor in triple-negative breast cancer patients treated with breast-conserving therapy: a large, single-institution retrospective analysis. Breast Cancer Res Treat 2013 Jun;139(2):497-506. doi: 10.1007/s10549-013-2550-x. Epub 2013 May 5. PMID: 23645006.

Ho AY, Gupta G, King TA, Perez CA, Patil SM, Rogers KH, Wen YH, Brogi E, Morrow M, Hudis CA, Traina T, McCormick B, Powell SN, Robson ME. Favorable prognosis in patients with T1a/T1bN0 triple-negative breast cancers treated with multimodality therapy. Cancer 2012 Oct 15;118(20):4944-52. doi: 10.1002/cncr.27480. Epub 2012 Mar 5. PMID: 22392492.

Hu YC, Grossberg MD, Wu A, Riaz N, Perez CA, Mageras GS. Interactive semiautomatic contour delineation using statistical conditional random fields framework. Med Phys 2012 Jul;39(7):4547-58. doi: 10.1118/1.4728979. PMID: 22830786; PMCID: PMC3412434.

Jaboin JJ, Hwang M, Perez CA, Cooper C, Chen H, Ye C, Cai Q, Wills ML, Lu B. No evidence for association of the MDM2-309 T/G promoter polymorphism with prostate cancer outcomes. Urol Oncol 2011 May-Jun;29(3):319-23. doi: 10.1016/j.urolonc.2009.03.031. Epub 2009 Jun 12. PMID: 19523862; PMCID: PMC3782416.

Perez CA, Chen H, Shyr Y, Courtney R, Zheng W, Cai Q, Hwang M, Jaboin J, Schleicher S, Moretti L, Wills M, Smith JA, Lu B. The EGFR polymorphism rs884419 is associated with freedom from recurrence in patients with resected prostate cancer. J Urol 2010 May;183(5):2062-9. doi: 10.1016/j.juro.2009.12.098. Epub 2010 Mar 19. PMID: 20303520; PMCID: PMC4165525.

Perez CA, Fu A, Onishko H, Hallahan DE, Geng L. Radiation induces an antitumour immune response to mouse melanoma. Int J Radiat Biol 2009 Dec;85(12):1126-36. doi: 10.3109/09553000903242099. PMID: 19995238.

Show More

Hwang M, Perez CA, Moretti L, Lu B. The mTOR signaling network: insights from its role during embryonic development. Curr Med Chem 2008;15(12):1192-208. doi: 10.2174/092986708784310459. PMID: 18473813.

Perez CA, Ott J, Mays DJ, Pietenpol JA. p63 consensus DNA-binding site: identification, analysis and application into a p63MH algorithm. Oncogene 2007 Nov 15;26(52):7363-70. doi: 10.1038/sj.onc.1210561. Epub 2007 Jun 11. PMID: 17563751.

Perez CA, Pietenpol JA. Transcriptional programs regulated by p63 in normal epithelium and tumors. Cell Cycle 2007 Feb 1;6(3):246-54. doi: 10.4161/cc.6.3.3801. Epub 2007 Feb 3. PMID: 17297308.

Barbieri CE, Perez CA, Johnson KN, Ely KA, Billheimer D, Pietenpol JA. IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium. Cancer Res 2005 Mar 15;65(6):2314-20. doi: 10.1158/0008-5472.CAN-04-3449. PMID: 15781645.

 

Last update: August 2024

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