Lindsey E Montefiori, PhD

Research Associate, St. Jude Faculty

Departments

Department of Pathology

Education

BS (Microbiology, Genetics) – North Carolina State University, Raleigh, USA
PhD (Genetics, Genomics and Systems Biology) – University of Chicago, Chicago, USA
Postdoctoral Fellowship – St. Jude Children’s Research Hospital, Memphis, USA

Research Interests

Lineage ambiguous leukemia
Gene regulatory mechanisms of oncogenic transcription factor activity
Developing novel approaches to therapeutically target oncogenic gene expression

Contact Information

Lindsey E Montefiori, PhD Departrment of Pathology MS 342, Room 4007B St. Jude Children's Research Hospital 262 Danny Thomas Place Memphis, TN 38105-3678

Email: Lindsey.Montefiori@stjude.org

Selected Publications

Kimura S, Park CS, Montefiori LE, Iacobucci I, Polonen P, Gao Q, Arnold E, Attarbaschi A, Brown A, Buldini B, Caldwell KJ, Chang Y, Chen C, Cheng C, Cheng Z, Choi J, Conter V, Crews KR, de Groot- Kruseman H, Deguchi T, Eguchi M, Muhle HE, Elitzur S, Escherich G, Freeman BB, Gu Z, Han K, Horibe K, Imamura T, Jeha S, Kato M, Chiew KH, Khan T, Kicinski M, Kohrer St, Kornblau S, Kotecha R, Li C-K, Liu Y-C, Locatelli F, Luger S, Paietta E, Manabe A, Marquart H, Masetti R, Maybury M, Mazilier P, Meijerink J, Mitchell S, Miyamura T, Moore A, Oshima K, Pawinska-Wasikowska K, Pieters R, Prater M, Pruett-Miller S, Pui C-H, Qu C, Reiterova M, Reyes N, Roberts KG, Rowe JM, Sato A, Schmiegelow K, Schrappe M, Shen S, Skoczen S, Spinelli O, Stary J, Svaton M, Takagi M, Takita J, Tang Y, Teachey D, Thomas P, Tomizawa D, Trka J, Varotto E, Vincent T, Yang J, Yeoh A, Zhou Y, Zimmerman M, Inaba H, Mullighan CG. Biologic and clinical analysis of childhood gamma delta T-ALL identifies LMO2/STAG2 rearrangements as extremely high risk. Cancer Discov. 2024. PMID: 38916500. DOI: 10.1158/2159-8290.CD-23-1452.

Polonen P, DiGiacomo D, Seffernick A, Elsayed Abdelrahman E, Kimura S, Benini F, Montefiori LE, Wood B, Xu J, Chen C, Cheng Z, Newman H, Myers J, Iacobucci I, Li E, Sussman J, Hedges D, Hui Y, Diorio C, Uppuluri L, Frank D, Fan Y, Chang Y, Meshinchi S, Ries R, Shraim R, Li A, Bernt K, Devidas M, Winter S, Dunsmore K, Inaba H, Carroll W, Ramirez N, Philips A, Kriwacki R, Yang J, Vincent T, Zhao Y, Ghate P, Wang J, Reilly C, Zhou X, Sanders M, Takita J, Kato M, Takasugi N, Chang B, Press R, Loh M, Rampersaud E, Raetz E, Hunger S, Tan K, Chang T, Wu G, Pounds S, Mullighan CG, Teachey D. The genomic basis of childhood T-lineage acute lymphoblastic leukemia. Nature. 2024DOI: 10.1038/s41586-024-07807-0.

Kimura S, Montefiori LE, Iacobucci I, Zhao Y, Gao Q, Paietta EM, Haferlach C, Laird AD, Mead PE, Gu Z, Stock W, Litzow MR, Rowe JM, Luger SM, Hunger SP, Ryland G, Schmidt BM, Ekert PG, Oshlack A, Grimmond S, Rehn J, Breen J, Yeung DT, White DL, Aldoss I, Jabbour EJ, Pui CH, Meggendorfer M, Walter W, Kern W, Haferlach T, Brady SW, Zhang J, Roberts KG, Blombery P, Mullighan CG. Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia. Blood. 2022 Jun 16;139(24):3519-3531. PMID: 35192684; PMCID: PMC9203703. DOI: 10.1182/blood.2022015444.

Montefiori LE, Seliger S, Gu Z, Chen X, Murison A, Zeng A, Garcia-Prat L, Ma X, Xu B, Chen Z, Dickerson K, Westover T, Ma J, Stengel A, Iacobucci I, Kimura S, Qu C, Valentine M, Rashkovan M, Luger S, Litzow M, Rowe J, den Boer M, Kornblau SM, Hunger SP, Loh ML, Pui C-H, Yang W, Crews K, Roberts KG, Yang J, Relling MV, Evans WE, Paietta E, Ferrando A, Stock W, Zhang J, Kern W, Haferlach T, Wu G, Dick JE, Klco JM, Haferlach C, Mullighan CG. Enhancer hijacking drives oncogenic BCL11B expression in lineage ambiguous stem cell leukemia. Cancer Discov. 2021 Nov;11(11):2846-2867.. PMID: 34103329; PMCID: PMC8563395. DOI: 10.1158/2159-8290.CD-21-0145.

Aneas I, Decker DC, Howard CL, Sobreira DR, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Tena J, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Gomez-Skarmeta JL, Schoetler N, Ober C, Sperling AI, Nobrega MA. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. Nat Commun. 2021 Oct 21;12(1):6115. PMID: 34675193; PMCID: PMC8531453. DOI: 10.1038/s41467-021-26347-z.

Joslin JC, Sobreira DR, Hansen GT, Sakabe NJ, Aneas I, Montefiori LE, Farris KM, Gu J, Lehman DM, Ober C, He X, Nobrega MA. A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci. Nat Commun. 2021 Sep 6;12(1):5253. PMID: 34489471; PMCID: PMC8421397. DOI: 10.1038/s41467-021-25614-3.

Schwartz JR, Ma J, Kamens J, Westover T, Walsh MP, Brady SW, Michael JR, Chen X, Montefiori LE, Song Guangchun, Wu G, Wu Huiyun, Branstetter C, Hiltenbrand R, Walsh MF, Nichols KE, Maciaszek JL, Liu Yanling, Kumar P, Easton J, Newman S, Rubnitz JE, Mullighan CG, Pounds S, Zhang J, Gruber T, Ma X, Klco JM. The acquisition of molecular drivers in pediatric therapy-related myeloid neoplasms. Nat Commun. 2021 Feb 12;12(1):985. PMID: 33579957; PMCID: PMC7880998. DOI: 10.1038/s41467-021-21255-8.

van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Hill MC, Montefiori LE, Scholman K, Boukens B, Goumans MJ, Efimov I, Nobrega M, Barnett P, Martin JF, Christoffels VM. Identification of atrial fibrillation associated genes and functional non-coding variants. Nat Commun. 2019 Oct 18;10(1):4755. PMID: 31628324; PMCID: PMC6802215. DOI: 10.1038/s41467-019-12721-5.

Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz MP, McNally EM, Nobrega MA. A promoter interaction map for cardiovascular disease genetics. eLife. 2018 Jul 10:7:e35788. PMID: 29988018; PMCID: 29988018. DOI: 10.7554/eLife.35788.

Boogerd JC, Zhu X, Aneas I, Sakabe NJ, Zhang L, Sobreira DS, Montefiori LE, Bogomolovas J, Joslin AC, Zhou B, Chen J, Nobrega M, Evans SM. Tbx20 is required in mid-gestation cardiomyocytes and plays a central role in atrial development. Circ. Res. 2018 Aug 3;123(4):428-442. PMID: 29903739; PMCID: PMC6092109. DOI: 10.1161/CIRCRESAHA.118.311339.

Montefiori LE, Hernandez L, Zhang Z, Ober C, Crawford G, Nobrega M, Sakabe NJ. Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9. Sci. Rep. 2017 May 26;7(1):2451. PMID: 28550296; PMCID: PMC5446398. DOI: 10.1038/s41598-017-02547-w.

Montefiori LE, Wuerffel R, Roqueiro D, Lajoie B, Guo C, Gerasimova T, De S, Wood W, Becker KG, Dekker J, Liang J, Sen R, Kenter AL. Extremely long-range chromatin loops link topological domains to facilitate a diverse antibody repertoire. Cell Rep. 2016 Feb 2;14(4):896-906. PMID: 26804913; PMCID: PMC4975037. DOI: 10.1016/j.celrep.2015.12.083.

Gerasimova T, Guo C, Ghosh A, Qiu X, Montefiori LE, Verma-Gaur J, Choi NM, Feeney AJ, Sen R. A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation. Genes & Dev. 2015 Aug 15;29(16):1683-95. PMID: 26302788; PMCID: PMC4561478. DOI: 10.1101/gad.263871.115.

Last update: October 2024