Children genetically prone to cancer benefit from early standardized surveillance

Recent advances in genomic sequencing have revealed that 5–15% of children with cancer have an underlying genetic predisposition. Although genetic predispositions increase the risk for new tumors, it has been unclear when to begin surveillance for these tumors. St. Jude Children’s Research Hospital scientists showed that beginning surveillance soon after recognizing a patient’s predisposition often led to discovering one or more early-stage asymptomatic tumors. About half of these tumors could be completely removed by surgery alone, thus avoiding the need for toxic chemotherapies or radiation therapies. The findings inform clinical practice after genetic testing and were published today in JAMA Oncology.

“We’ve shown that following standardized surveillance protocols provides a very effective way to detect new tumors at their earliest and most treatable stages,” said corresponding author Kim Nichols, MD, St. Jude Division of Cancer Predisposition director, Department of Oncology. “Understanding whether children have an underlying genetic risk for cancer can greatly impact their clinical care, and proactive surveillance for new tumors is an important component of this care.”

Findings showed the benefit of early surveillance applied across multiple cancer types and predisposing conditions. The researchers examined 274 St. Jude pediatric patients with 35 different cancer-predisposing conditions over a median of three years. Surveillance revealed tumors in 27 patients, representing a broad array of solid and central nervous system neoplasms. 

Early detection leads to better treatment

Conventional practice typically results in surveillance that begins months to years after detecting a genetic predisposition. Further, data on the effectiveness and outcomes of surveillance are sparse. Strikingly, most of the new cancers detected in the study were found with early surveillance right after the genetic predisposition was discovered. Nearly one out of every three tumors were found at the first surveillance intervention soon after diagnosis, and two out of three were found within two years of that initial surveillance visit. Surprisingly, this included a small subset of children already being treated for a different cancer.

“About 17% of the children had a new tumor identified while they were still undergoing treatment for a prior cancer,” Nichols said. “Often, providers wait until a child has finished treatment for their first cancer before they start screening for other potential malignancies. If you do that, it is possible you’re going to miss a new tumor. Providers should now recognize the importance of starting the recommended surveillance tests the moment they discover an underlying predisposition.”

Beginning surveillance right away also resulted in finding cancers in earlier stages. Without the early screening, many of the tumors would have remained unnoticed until much later because almost all were asymptomatic at the time of discovery. By finding these tumors at an early stage, oncologists could remove most of them by surgery alone. In addition, findings showed that most tumors (around 70%) were entirely removed without leaving even microscopic traces behind. 

“We were able to remove these tumors without any evidence of disease left behind,” Nichols said. “These patients will have better outcomes and may need less or even no chemotherapy or radiation therapy.” Avoiding chemotherapy and radiation can prevent long-term treatment-related side effects, a poignant consideration when treating children.