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Genetic variants linked to heart health in African American childhood cancer survivors
12/07/2020
St. Jude scientists identified genetic variants in African American childhood cancer survivors that have implications for up-front care and long-term surveillance.
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Research reveals how a fungal infection activates inflammation
12/02/2020
Scientists at St. Jude have shed light on the mechanisms that underlie how Aspergillus fumigatus activates the inflammasome, with implications for therapeutic development.
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In the lab, St. Jude scientists identify possible COVID-19 treatment
11/18/2020
Immunologists have determined the process driving life-threatening inflammation, lung damage and organ failure in patients with COVID-19, sepsis and other inflammatory disorders suggesting possible treatment using existing drugs.
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Sara Federico, M.D., receives NCI award for her leadership in developing clinical trials for pediatric cancer
11/18/2020
Sara Federico, MD, received the NCI award for substantial impact in the field of childhood solid tumors through the development and conduct of clinical trials.
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St. Jude researchers are among the most highly cited scientists in the last decade
11/18/2020
Scientists at St. Jude Children’s Research Hospital are included on the Highly Cited Researchers 2020 list, which features some of the world’s most influential researchers.
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Metabolic signaling plays a crucial role in regulating specialized T cells
11/17/2020
Scientists at St. Jude Children’s Research Hospital have identified how metabolic signaling pathways influence key immune cells with implications for treating autoimmune disorders and cancer.
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Cytokine storms play a limited role in moderate-to-severe COVID-19
11/13/2020
St. Jude Children’s Research Hospital and Washington University research suggests steroids such as dexamethasone should be reserved for the sickest COVID-19 patients.
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St. Jude and the University of Tennessee Health Science Center begin recruiting adult participants for phase 3 COVID-19 vaccine clinical trial
11/13/2020
St. Jude Children’s Research Hospital and the University of Tennessee Health Science Center will offer a testing site for a phase 3 COVID-19 vaccine clinical research study.
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St. Jude Nurse Residency Program accredited as a leading program for young professionals
11/12/2020
The St. Jude Children's Research Hospital inpatient Nurse Residency Program has been accredited by the American Nurses Credentialing Center (ANCC) as a Practice Transition Program.
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Molecular mechanisms reveal how to make the most of methotrexate
11/09/2020
Scientists at St. Jude Children’s Research Hospital have found five factors that explain why children respond differently to the chemotherapy drug methotrexate.
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Why do many drugs work in the lab but fail to get to the clinic?
11/04/2020
Researchers identify new forms of membrane proteins that offer drug development targets to minimize medication side effects.
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How do neurons develop?
10/28/2020
St. Jude researchers are studying the Siah2 protein to determine how brain cells mature.
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Research advances understanding of life-threatening lung inflammation following the flu
10/28/2020
Preclinical studies are underway at St. Jude Children’s Research Hospital to develop small molecule inhibitors to prevent deadly inflammation and lung damage following respiratory infections and asthma.
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Tanja Mittag to receive 2021 Michael and Kate Barany Award
10/23/2020
Award recognizes her contributions in the field of biophysics
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Researchers mine data and connect the dots about processes driving neuroblastoma
10/14/2020
St. Jude Children’s Research Hospital scientists lead genome analysis to better understand one of the most common childhood solid tumors.
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St. Jude achieves Magnet® designation for nursing services for the second time
10/12/2020
Magnet® designation is the highest honor bestowed in nursing and serves as a benchmark for patients to measure the quality of nursing care they can expect to receive at a hospital.
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Making the invisible visible: NMR insights set stage for next-gen targeted cancer therapies for adults and children
10/01/2020
St. Jude researchers used leading-edge technology to visualize fleeting protein shapes with implications for resistance to targeted cancer treatments, NMR spectrometer
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St. Jude recognized as clinical care center for rare von Hippel-Lindau syndrome
09/30/2020
St. Jude is the first and only VHL Alliance-recognized Clinical Care Center dedicated solely to children.
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St. Jude immunologist Thirumala-Devi Kanneganti, Ph.D., receives NCI Outstanding Investigator Award
09/24/2020
The National Cancer Institute award provides extended support for researchers to pursue projects with groundbreaking cancer research potential
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Building bridges: PARP enzymes bring broken DNA together
09/16/2020
St. Jude researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process.
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Study reveals structure of DUOX1 complex
09/15/2020
Researchers are learning more about how DUOX1 complex contributes to disease.
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St. Jude Children’s Research Hospital to begin constructing new patient housing facility
09/14/2020
Domino’s announced that it is committing to raise $100 million for St. Jude during the next 10 years.
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Inherited genetic variant influences response to leukemia treatment for some children
09/11/2020
St. Jude researchers showed that an inherited variant of the GATA3 gene is tied to minimal residual disease levels and response to therapy for ALL
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Want to block flu transmission? Targeting nasal bacteria may help
09/09/2020
St. Jude Children’s Research Hospital scientists report that respiratory bacteria aid spread of flu virus .
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Screenings for cardiac dysfunction among childhood cancer survivors can be more precisely tailored
08/14/2020
New guidelines may be warranted for childhood cancer survivors at low and high risk of cardiac late effects.
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Targeting the LANDO pathway holds a potential clue to treating Alzheimer’s disease
08/14/2020
Reducing neuroinflammation by disrupting a protein involved in recycling cellular components may provide a potential therapeutic approach for treating neurodegeneration and memory loss.
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John Crispino named to head the Division of Experimental Hematology at St. Jude
08/13/2020
Crispino’s research focuses on acute leukemia in children with Down syndrome and blood cell development
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St. Jude Children’s Research Hospital Graduate School of Biomedical Sciences adds Master of Science in Clinical Investigations
08/12/2020
New program looking to attract professionals or students interested in clinical research
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Hearing loss linked to neurocognitive deficits in childhood cancer survivors
07/30/2020
Research shows that severe hearing loss in childhood cancer survivors is associated with neurocognitive deficits independent of type of therapy.
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Heather Brandt, Ph.D., to lead cancer prevention community outreach projects for St. Jude
07/23/2020
Behavioral scientist will lead St. Jude community outreach and research programs focused on the prevention of HPV-associated cancers through vaccination
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David Rogers named chair of the Department of Pharmaceutical Sciences at St. Jude Children’s Research Hospital
07/15/2020
Rogers replaces the retiring longtime Department Chair Mary Relling
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Pat Keel named executive vice president and chief administrative and financial officer for St. Jude Children’s Research Hospital
07/08/2020
Pat Keel's promotion includes oversight of numerous departments vital to campus operations
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St. Jude researchers create an analytic tool that opens a new frontier of cancer discovery
07/06/2020
St. Jude Children’s Research Hospital scientists have developed software to identify cancer-causing mutations lurking in vast regions of the human genome
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M. Madan Babu joins St. Jude Children’s Research Hospital as endowed chair in biological data science
06/30/2020
Position will enhance data-driven biomedical research at St. Jude
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St. Jude Cloud portal expands access to treasure trove of pediatric solid tumor data
06/26/2020
St. Jude Children’s Research Hospital develops the Childhood Solid Tumor Network data portal to speed discoveries and novel therapies for treatment of childhood solid tumors.
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Inherited mutation found among Brazilians increases cancer risk
06/24/2020
Genomic research helps explain why some people with a common TP53 mutation widespread in Brazil get cancer while others do not.
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St. Jude creates resource for pediatric brain tumor research
06/23/2020
Researchers worldwide can access orthotopic patient-derived xenograft models to speed discovery and test novel therapies for childhood brain tumors.
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St. Jude Children’s Research Hospital president and CEO honored for contributions to pediatric cancer research
06/22/2020
James R. Downing, M.D., receives inaugural award from prestigious cancer research association.
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St. Jude pediatric oncologist Dylan Graetz receives Young Investigator Award from ASCO
06/18/2020
Dylan Graetz, M.D., M.P.H., a pediatric hematology-oncology fellow at St. Jude, has received a Young Investigator Award from the American Society of Clinical Oncology.
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CICERO software enables detection of cancer-causing gene fusions
06/15/2020
St. Jude Children’s Research Hospital software enables detection of previously unknown cancer-causing gene fusions, pointing the way to new treatments.
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Streamlined and scalable CHANGE-Seq method improves understanding of genome editors
06/15/2020
New research tool helps define unintended off-target effects of CRISPR genome editing, making the process safer and more precise.
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Cytokine implicated in HLH treatment resistance
06/12/2020
Research sheds light on cytokine storm syndromes and how ruxolitinib may benefit patients with hemophagocytic lymphohistiocytosis.
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Kiri Ness, Ph.D., of St. Jude receives award for outstanding contributions to professional literature from American Physical Therapy Association
06/09/2020
Kiri Ness, Ph.D., is the 2020 recipient of the Helen J. Hislop Award for Outstanding Contributions to Professional Literature.
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Identifying survivors at high risk of secondary cancers
06/04/2020
St. Jude researchers look at the combined effect of cancer treatments and inherited mutations in DNA-repair genes.
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Sahaja Acharya, M.D., of St. Jude receives early career development award from ASCO
06/01/2020
Sahaja Acharya, M.D., a radiation oncologist at St. Jude, has received a 2020 Career Development Award from the American Society of Clinical Oncology (ASCO) Conquer Cancer foundation.
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Melissa Hudson, M.D., of St. Jude wins award for outstanding contributions to childhood cancer survivorship
05/27/2020
St. Jude investigator Melissa Hudson, M.D., is named the 2020 recipient of the Northwestern Mutual Award for Excellence in Childhood Cancer Survivorship by the American Society of Pediatric Hematology/Oncology.
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Caspase-8 triggers inflammatory signaling in multiple ways
05/18/2020
Beyond its role in cell death, St. Jude scientists have uncovered how caspase-8 contributes to inflammation.
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Scientists study how bacteria evolve to resist antibiotics
05/11/2020
Researchers at St. Jude contribute to a study of bacteria and its evolving resistance to antibiotics.
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St. Jude awarded federal grant for Emerging Frontiers in Research and Innovation
05/07/2020
St. Jude Children’s Research Hospital has received a National Science Foundation grant to integrate biology and engineering at the molecular level to tackle childhood disease.
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Research reveals complexity of phase separation
05/06/2020
St. Jude researchers contribute to studying the nucleolus to learn more about phase separation.
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Pediatric neurologist Richard Finkel, M.D., joins St. Jude Children's Research Hospital
05/06/2020
A leading expert in pediatric neurologic disorders, Richard S. Finkel, M.D., will lead the new Center for Experimental Neurotherapeutics at St. Jude Children’s Research Hospital.
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Douglas R. Green, Ph.D., of St. Jude elected to the National Academy of Sciences
04/30/2020
St. Jude Children’s Research Hospital immunologist recognized for his contribution to understanding the mechanism of cell death and survival.
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Global COVID-19 Observatory and Resource Center for Childhood Cancer to serve as hub for sharing information on treating pediatric cancer patients infected by the virus
04/16/2020
Oncologists and other health care providers from across the world to contribute data and share best practices in real time.
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Network of protein-RNA interaction guides phase separation
04/16/2020
Scientists at St. Jude have identified a mechanism that controls how phase separation leads to the formation of stress granules in cells.
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Discovering the secrets of the enigmatic caspase-6
04/15/2020
Researchers identified the mechanisms underlying the innate immune function of the enzyme caspase-6, offering ways to combat viral infection, inflammatory diseases and cancer.
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St. Jude experimental anti-malarial drug shows promise in first clinical trial
04/07/2020
Malaria is a leading killer of children worldwide, and new drugs are needed. New research reports encouraging early clinical results with a new compound.
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Inherited mutation can predispose children to a type of brain tumor
04/01/2020
Collaboration co-led by researchers at St. Jude Children’s Research Hospital discovers a novel predisposition gene in pediatric medulloblastoma.
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Significant global investment could save 11 million children
04/01/2020
A report shows an investment in treating children with cancer could save 11 million lives and produce a triple return on investment to the global economy.
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Targeting a transporter to treat SHH medulloblastoma
03/31/2020
Scientists at St. Jude Children’s Research Hospital have identified a novel target for a type of pediatric brain tumor.
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Biological ‘atlas’ shows dual personality for immune cells that cause Type 1 diabetes
03/30/2020
Scientists at St. Jude mapped the epigenetic controls on T cells, which could aid Type 1 diabetes diagnosis and treatment, as well as cancer immunotherapy.
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St. Jude COVID-19 Update for March 25, 2020
03/25/2020
To protect our patients and in adherence with the Memphis Safer at Home order, St. Jude is implementing enhanced precautions on campus.
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St. Jude COVID-19 Update for March 21, 2020
03/21/2020
Our patients and their families are our highest priority. We remain focused on ensuring the health and safety of those we serve. Read our latest on COVID-19.
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The role of oxygen in wiring the brain
03/16/2020
Scientists at St. Jude are studying the role oxygen plays in the maturation and migration of neurons and have identified a new mechanism that helps control these processes.
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St. Jude finds cancer drug resistance genes and possibly how to limit their effects
03/09/2020
Drug resistance is a leading cause of cancer death in children and adults with leukemia. St. Jude Children’s Research Hospital scientists have.
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Pediatric Oncologist Ching-Hon Pui, M.D., receives Medal of Honor from the American Cancer Society
03/03/2020
St. Jude Children's Research Hospital pediatrician and researcher is honored for significant contributions to the advancement and impact of global collective efforts to save more lives from childhood cancer.
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Obesity linked to severity and longer duration of flu
03/03/2020
New research suggests that obesity may be linked to increased severity and longer duration of the flu as well as higher amounts of flu in the body.
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Study reveals properties of cells fated to relapse in acute lymphoblastic leukemia
03/02/2020
Researchers have found that genetically defined subpopulations of leukemia cells present at diagnosis have distinct characteristics that lead to relapse.
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Mapping genetic variants driving toxicity to leukemia therapy
02/24/2020
Scientists at St. Jude Children’s Research Hospital have created an extensive map of NUDT15 variants to more accurately predict toxicity from the critical cancer drugs thiopurines.
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Unraveling mechanisms of ventricular enlargement linked to schizophrenia
02/14/2020
Scientists at St. Jude Children’s Research Hospital have implicated two microRNAs in the biological processes that underlie the ventricle enlargement observed in models of schizophrenia.
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New website powered by St. Jude informs families facing childhood cancer no matter where the patient receives treatment
02/12/2020
Together, a resource on childhood cancer for patients and families, is winning awards for innovation, clear language and patient education.
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Researchers create a stickers-and-spacers model for predicting protein phase separation
02/06/2020
By identifying these models, St. Jude researchers believe that they can predict liquid-liquid phase separation, which is an important activity for cells. Learn more.
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The Pediatric Cancer Genome Project at 10: The impact lives on
01/27/2020
The Pediatric Cancer Genome Project marks a decade of discovery that has advanced understanding, diagnosis and treatment of childhood cancer.
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St. Jude Children’s Research Hospital names Motomi Mori chair of Biostatistics
01/23/2020
Motomi Mori Ph.D., expert in cancer genetic analysis, will join St. Jude as chair of the Department of Biostatistics and will hold the Endowed Chair in Biostatistics
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Partnership with China prompts change in care for high-risk type of leukemia
01/16/2020
Findings from a collaborative clinical trial have generated key insights into how targeted therapy should be used to treat leukemia driven by the Philadelphia chromosome.
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St. Jude hematologist Akshay Sharma receives ASH 2020 Scholar Award
01/10/2020
Akshay Sharma, MBBS, of St. Jude is the recipient of a 2020 Scholar Award from the American Society of Hematology (ASH).
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St. Jude announces plans to build new shared resource center
01/09/2020
The new Shared Resource Center will enhance the capabilities of St. Jude researchers looking to discover new treatments for pediatric cancer.
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Comprehensive protein analysis offers clues to progression of Alzheimer’s disease
01/08/2020
St. Jude Children’s Research Hospital scientists have identified proteins that play critical roles in Alzheimer’s disease and provide a framework for developing new diagnostic and treatment strategies.
