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Research reveals machinery of a deadly childhood brain cancer
12/27/2018
Investigators studied the effects of the H3 K27M mutation, and revealed its impact on mutations that are known drivers of DIPGs.
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Newly identified subset of immune cells may be key to fighting chronic inflammation
12/20/2018
Read about the newly identified subset of helper T 17 immune cells that suggest a novel approach for taming chronic inflammation.
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Researchers report how molecular partners form dynamic scaffolding for protein machinery
12/05/2018
Scientific discovery by St. Jude group could lead to new pathway for cancer treatment and understanding of ALS.
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St. Jude research into leukemia, sickle cell and other blood disorders presented at ASH
11/30/2018
The 2018 annual meeting of the American Society of Hematology will include research from St. Jude that stretches from the laboratory to the clinic.
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St. Jude at the American Society of Hematology (ASH) 2018 annual meeting
11/28/2018
St. Jude scientists and clinicians highlighted at the annual American Society of Hematology in San Diego. Read the latest.
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St. Jude announces extensive resource to advance leukemia research
11/14/2018
The Public Resource of Patient-derived and Expanded Leukemias (PROPEL) offers patient-derived xenograft samples free of charge for researchers worldwide.
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Researchers reveal why Hippo pathway may have an outsized effect on solid tumor
10/30/2018
A surprising mechanism that might explain how the Hippo signaling pathway promotes solid tumor growth.
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Small risks may have big impact on breast cancer odds of childhood cancer survivors
10/26/2018
Common genetic variations may help find female childhood cancer survivors at increased risk of breast cancer and who are candidates for stepped up screening.
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Obesity problem starts early phase of therapy in children with acute lymphoblastic leukemia
10/25/2018
Children with ALL gain weight during treatment, and researchers suggest that early interventions should be considered.
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Collaboration yields possible treatment for rare neurodegenerative disorder
10/23/2018
Read how a discovery in bacteria in the 1980s led to a promising new class of compounds for treatment of PKAN, a progressive neurodegenerative disease.
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Reprogramming immune cells to fight tumors from within
10/19/2018
Scientists have a new strategy to enhance the anti-cancer immune response and slow tumor growth. The goal is to reprogram macrophages to eliminate tumor cells.
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St. Jude investigators present novel pediatric cancer genome sequencing data at ASHG
10/17/2018
Presentations outline data from Genomes for Kids study, proving clinical utility of multi-platform genome sequencing for pediatric precision oncology.
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Researchers find a ‘critical need’ for whole genome sequencing of young cancer patients
10/11/2018
Including whole-genome sequencing into clinical genomic testing found cancer-driving mutations other sequencing methods failed to identify.
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St. Jude researchers awarded grant to lead pharmacogenetics implementation efforts
10/04/2018
The funding will support CPIC, which provides guidelines to help clinicians understand how genetic test results should be used to optimize drug therapy.
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World Health Organization, St. Jude Children’s Research Hospital collaborate against childhood cancer
09/27/2018
New global childhood cancer effort aims to cure at least 60 percent of children with six of the most common kinds of cancer worldwide by 2030.
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Method identified to reduce risk of brain damage in leukemia survivors
09/24/2018
St. Jude scientists have discovered a link between sepsis during cancer treatment and long-term neurocognitive dysfunction.
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What can salad dressing tell us about cancer? Think oil and vinegar.
09/20/2018
Evidence suggests liquid phase separation, a process that explains why oil and water separate, may contribute to cancer, including prostate cancer.
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High-resolution genomic map gives scientists unprecedented view of brain development
09/13/2018
The research will aid basic understanding of brain development, and also help understanding cellular origins of brain disorders caused by errors in development.
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Discovery of a cancer promoter offers pathway to overcome drug resistance
09/12/2018
Geneticists discovered that mTORC3 aids cancers' resistance to rapamycin and related drugs, offering the promise of new drug therapies to treat cancers.
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St. Jude researchers solve a central mystery of a baffling high-risk leukemia
09/12/2018
Read the latest on the roots of mixed phenotype acute leukemia (MPAL), including how the findings might affect treatment of patients with the high-risk cancer.
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Immune system prioritizes distinct immune responses in infants with flu
08/28/2018
Flu infections pose a significant risk to infants. Read about the T cells the immune system relies on to repair lung damage in infants infected with influenza.
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Integrated analysis finds vulnerabilities to target in a high-risk pediatric tumor
08/23/2018
Read about what happened when researchers looked beyond mutations to understand the developmental origins and vulnerabilities of rhabdomyosarcoma.
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St. Jude achieves consecutive highest rating from National Cancer Institute during Cancer Center renewal grant
08/22/2018
St. Jude is the first and only NCI-designated Comprehensive Cancer Center that is devoted solely to children.
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Late effects of treatment hinder independence of adult survivors of childhood brain tumors
08/09/2018
St. Jude investigators find that cognitive impairment and physical performance limitations are strong predictors of non-independence in survivors.
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Financial checkup should be part of health screenings for childhood cancer survivors
08/01/2018
Financial hardship is widespread among childhood cancer survivors, reducing their quality of life and leaving them at risk for depression, other problems.
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Solution to medical mystery may help some children avoid bone marrow transplantation
07/26/2018
Researchers identify mutations responsible for an inherited bone marrow disorder and evidence some affected patients may regain normal immune function without treatment.
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St. Jude collaborates to improve knowledge of childhood cancer worldwide
07/18/2018
The partnership with Institute for Health Metrics and Evaluation will provide more accurate estimates of the global burden of cancer among children.
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Scientists identify a protein complex that shapes the destiny of T cells
07/06/2018
Metabolic activity in immune cells influences the fate of developing T cells, including a protein complex that plays a decisive role.
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"Substantial portion" of childhood cancer survivors not concerned about their future health
06/25/2018
Surveys from the Childhood Cancer Survivor Study found that a surprisingly high number of survivors showed a lack of concern for their future well-being.
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Engineered 'starter key' for brain tumor offers new model for drug testing
06/25/2018
Researchers have applied a new way to trigger medulloblastoma in neural cells that will lead to the ability to test a promising class of anti-tumor drugs.
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St. Jude CEO James Downing ranked No. 5 of Glassdoor’s Top 100 CEOs
06/20/2018
Under Downing’s leadership, St. Jude has increased employee feedback channels and forums, resulting in more innovation and connectivity across the Memphis-based campus.
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Researchers develop a better method to compare gene expression in single cells
06/19/2018
Check out a new algorithm that is available at no cost to help researchers get the most out of single-cell RNA sequencing technology.
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Genetic counseling suggested for all childhood cancer survivors
06/19/2018
St. Jude has completed the first genome sequencing of cancer survivors and found that 12 percent of childhood cancer survivors may have a higher risk of cancer.
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St. Jude partners with nation’s top cancer centers to endorse goal of eliminating HPV-related cancers in the United States
06/07/2018
Joint statement empowers parents, young adults and physicians to act to increase vaccination rates and screenings to eliminate HPV-related cancers
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Rigorous study finds widely used treatment for infection fails young cancer patients
06/05/2018
Study found ethanol-lock therapy failed to prevent new or recurring infections in cancer patients with central venous catheters and led to more complications.
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Pediatric cancer research highlighted at ASCO Annual Meeting
05/31/2018
St. Jude experts share pediatric oncology and survivorship research at the annual meeting of the American Society of Clinical Oncology.
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‘Hidden’ driver discovered that helps prime the anti-tumor immune response
05/30/2018
Read about the algorithm that helped researchers uncover hidden drivers of immune regulation and production of anti-tumor T cells.
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St. Jude Children's Research Hospital expands international reach with St. Jude Global
05/24/2018
Hospital invests more than $100 million to improve childhood cancer survival rates worldwide.
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St. Jude trial identifies a medulloblastoma subset that requires less aggressive therapy
05/17/2018
For a subset of the youngest patients with the brain tumor medulloblastoma, less aggressive therapy was associated with better long-term survival.
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‘Lone wolf’ protein offers new pathway to cancer treatments
05/16/2018
The protein called BOK offers another target for drugs to selectively trigger apoptosis.
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St. Jude named the World Health Organization’s first Collaborating Centre for Childhood Cancer
05/16/2018
St. Jude is partnering with WHO to develop strategies that strengthen the global resources, organization and planning needed to identify and treat pediatric cancer.
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Genetic counseling and testing proposed for patients with the brain tumor medulloblastoma
05/09/2018
Researchers created the first genetic screening guidelines for medulloblastoma patients after identifying gene variations that make carriers susceptible.
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Research pinpoints viral mutation that would trigger resistance to new anti-influenza drugs
04/24/2018
Using combination therapy for flu, a new class of drug offers potential for multi-drug therapy and possibly improved influenza-fighting drugs.
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Discovery adds to evidence that some children are predisposed to develop leukemia
04/19/2018
A family’s history of childhood leukemia leads to the discovery of a fourth gene (IKZF1) that predisposes carriers to pediatric acute lymphoblastic leukemia.
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St. Jude at AACR 2018
04/12/2018
Explore research and resources by St. Jude at the annual meeting of the American Association for Cancer Research (AACR) in Chicago.
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St. Jude Cloud, largest public repository of pediatric cancer genomics data, launches for researchers worldwide
04/12/2018
St. Jude to offer next-generation sequencing data and analysis tools to accelerate research and cures for life-threatening pediatric diseases.
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Neurocognitive risk may begin before treatment for young leukemia patients
03/29/2018
What explains cognitive problems in childhood leukemia survivors treated with chemotherapy alone? The answer may be a surprise.
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Researchers discover a ‘security chief’ that helps sound the alarm against infections
03/22/2018
Read about the molecule (IRF8) that is essential for launching an optimal immune response to Salmonella, Pseudomonas and related bacteria.
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Immune system 'double agent' could be new ally in cancer fight
03/15/2018
The immune system is full of surprises. Here is one about a kinase that plays an unexpected role in regulating inflammation and cell death in myeloid cells.
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Study identifies potential drug for treatment of debilitating inherited neurological disease
03/14/2018
St. Jude scientists have demonstrated in model studies that the neurological disease spinal bulbar muscular atrophy (SBMA) can be successfully treated with drugs.
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Many adolescent and young adult cancer survivors have more social connections than peers
03/08/2018
Researchers have developed a new method to measure social networks of adolescent and young adult cancer survivors. What they found might surprise you.
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Researchers home in on possible drug to prevent hearing loss
03/07/2018
Millions of people have lost their hearing due to noise, chemotherapy, age or other insults. Read about efforts to help prevent such losses in the future.
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‘Rheostat’ identified that helps regulate cell death versus survival decisions
03/05/2018
A little disorder is helpful sometimes. Read how an intrinsically disordered region of the protein Bcl-xL helps cells integrate messages regarding apoptosis.
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Genomic analysis underscores need for precision therapies that target pediatric cancer
02/28/2018
The most comprehensive look ever across the genomic landscape of childhood cancer reinforces the need for precision medicine to treat pediatric cancer.
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Effective pediatric cancer treatment is possible in the midst of a refugee crisis
02/28/2018
War in Syria sent refugees flooding into Lebanon. Read about the life-saving effort to deliver effective treatment to refugee children with cancer.
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St. Jude Children's Research Hospital, Microsoft and DNAnexus join forces to fuel scientific discovery
02/28/2018
Partnership established to analyze and store pediatric cancer genomics data, support data sharing and encourage greater collaboration among scientists worldwide.
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Study reveals key inner control mechanism of cell's 'smart glue'
02/26/2018
St. Jude researchers reveal importance of nucleophosmin during liquid-liquid phase separation and the proteins’ role in the structure of the nucleolus.
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St. Jude to develop $412 million research center to advance discovery
02/19/2018
The advanced research center builds on the St. Jude legacy of innovations for understanding and treating childhood cancer and other life-threatening diseases.
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St. Jude Children's Research Hospital named to Fortune magazine’s ‘100 Best Companies to Work For’ for eighth consecutive year
02/15/2018
St. Jude recognized for having exceptional workplace culture based upon employee surveys and an in-depth questionnaire.
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‘Hijacker’ drives cancer in some patients with high-risk neuroblastoma
01/23/2018
Researchers used a new method to model the cancer genome in 3-D and show how the c-MYC oncogene drives high-risk neuroblastoma in some patients.
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St. Jude names Robin Mutz chief nurse executive and senior vice president
01/16/2018
Mutz will play a key role in the St. Jude Strategic Plan and future hospital expansion.
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St. Jude initiative boosts whooping cough vaccination rate
01/10/2018
Quality improvement effort shows the way to enhance vaccination among health care providers and protect patients.
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Researchers discover that a “muscle” cancer is not really a muscle cancer
01/08/2018
St. Jude researchers pinpoint the cell type that turns malignant in rhabdomyosarcoma, which could open the path for better treatments.
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Tumor suppressor gene variants identified as cancer ‘double whammy’ for leukemia patients
01/04/2018
Read about the TP53 gene variations that leave young people more likely to develop acute lymphoblastic leukemia and to die as a result.
