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Memory T cells responsible for long-term immunity have been cross-trained
12/13/2017
Advances in understanding the origins of memory CD8 T cells should aid efforts to create more effective vaccines and immunotherapies to help protect against cancer relapse.
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St. Jude gene therapy improves immunity in babies with 'bubble boy' disease
12/09/2017
Early results suggest gene therapy is well tolerated and effective for babies with X-linked severe combined immunodeficiency disorder, or "bubble boy" disease.
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St. Jude Children's Research Hospital named to Glassdoor's Best Places to Work 2018
12/08/2017
St. Jude ranks 9 out of Top 100 large companies on Glassdoor’s Best Places to Work 2018 list.
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Anti-malaria drug increases sensitivity of high-risk leukemic cells to targeted therapy
12/01/2017
A drug widely used against malaria sensitizes the high-risk leukemia BCR-ABL positive ALL to a precision medicine and may enhance treatment.
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St. Jude at the American Society of Hematology 2017 annual meeting
11/29/2017
St. Jude scientists, clinicians and leadership highlighted at the annual American Society of Hematology in Atlanta. Read the latest.
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Researchers discover an Achilles heel in a lethal leukemia
11/16/2017
Researchers have discovered how a linkage between two proteins in AML enables cancer cells to resist chemotherapy- disrupting the linkage could become a treatment pathway.
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Increasing hydroxyurea dose helps to keep young sickle cell patients out of the hospital
11/09/2017
Higher doses of hydroxyurea in children with sickle cell disease boosts their fetal hemoglobin levels and significantly reduces hospitalizations.
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New pathway identified as a target for precision medicine against a common brain tumor
11/02/2017
A newly identified component of the Sonic Hedgehog pathway offers another target for precision medicine for treatment of SHH medulloblastoma subtype
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Flu vaccine failed to protect young leukemia patients during cancer treatment
10/16/2017
The flu shot may not protect pediatric leukemia patients from influenza during cancer treatment, highlighting the need for additional safeguards.
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Sperm banking is underutilized by adolescent and young adult cancer patients
10/04/2017
Despite the fertility risk, most young male cancer patients don’t bank sperm before beginning cancer treatment.
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Researchers discover how enzyme 'shape-shifts' in drug-resistant leukemia
09/25/2017
New treatment strategies to overcome drug resistance in chronic myelogenous leukemia and other cancers will come from the detailed structure of the enzyme Abl.
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Life-long blood production depends on hundreds of cells that form prior to birth
09/18/2017
How many blood-forming stem cells are present at birth to keep us supplied with blood cells for a lifetime? It is more than previously thought.
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Antibiotic identified that reduces infection risk in young leukemia patients
09/14/2017
Prophylactic antibiotic therapy with levofloxacin is safe and effective for reducing treatment-related infections in pediatric leukemia patients.
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Comprehensive study of chronic disease reveals vulnerability of childhood cancer survivors
09/07/2017
The severity and complexity of chronic disease in adult survivors of childhood cancer suggest that a new approach to healthcare delivery is needed.
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St. Jude unveils powerful resource to advance treatment of pediatric solid tumors
08/30/2017
Childhood Solid Tumor Network offers the world’s largest and most comprehensive collection of scientific resources for studying pediatric solid tumors
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HPV vaccination rates lag for vulnerable population of childhood cancer survivors
08/24/2017
Health provider recommendation most important predictor of HPV vaccination of adolescent and young adult survivors of childhood cancer.
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Allergies? Exhausted regulatory T cells may play a role
08/24/2017
Regulatory T cells show evidence of functional exhaustion in research that underscores the importance of immunometabolism for immune balance.
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Researchers discover fundamental pathology behind ALS
08/16/2017
Identifying the basic cellular malfunction underlying ALS opens the pathway to developing treatments to prevent the disease by preserving neurons.
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Discovery points to drugs that would ‘short-circuit’ deadly leukemia
08/03/2017
St. Jude researchers have found that cells of a deadly acute myeloid leukemia can be killed by blocking production of a molecular “battery.”
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St. Jude names Charalampos Kalodimos chair of Department of Structural Biology
08/02/2017
Dr. Kalodimos’ appointment will further strengthen basic science programs that serve as the foundation of discovery.
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St. Jude Children's Research Hospital signs agreement to commercialize RSV vaccine
07/31/2017
Agreement with Serum Institute of India to develop a vaccine for respiratory syncytial virus, a lower respiratory tract infection in infants and children.
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Boat-shaped membrane protein offers novel solution for working in the cell membrane
07/21/2017
Novel boat-shaped membrane protein provides an architectural solution for PlsC and likely thousands of other enzymes that work within the cell membrane.
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Definitive genomic study reveals alterations driving most medulloblastoma brain tumors
07/19/2017
Landmark study of the most common pediatric brain tumor reveals new cancer genes and lays the foundation to expand precision medicine.
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Engineered yeast yields insight into machinery of deadly brain tumor
07/18/2017
Researchers offer clues on how mutations in the histone H3 cripple DNA replication and genomic instability, which contribute to development of high-grade glioma.
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Newly identified genetic marker may help detect high-risk flu patients
07/17/2017
Researchers have identified a possible genetic marker of influenza severity and evidence it affects the supply of killer T cells that help fight the infection.
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Improved recognition to help fertility preservation for cancer patients
07/06/2017
Premature ovarian insufficiency leaves childhood cancer survivors at risk for infertility, weak bones and poor health.
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Genomic analysis of key acute leukemia will likely yield new therapies
07/03/2017
Landmark study of T-lineage acute lymphoblastic leukemia (T-ALL) reveals new mutations and drug development targets.
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Controlling a single brain chemical may help expand window for learning language and music
06/29/2017
Extending the age window for learning language and music may depend on dialing down the neuromodulator adenosine.
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Researchers chart pathway to 'rejuvenating' immune cells to fight cancers
06/28/2017
Enhanced immunotherapies against cancer and viral infections may be on the horizon thanks to a new strategy to combat T cell exhaustion.
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U.S. News & World Report Ranks St. Jude Children’s Research Hospital as No. 1 Pediatric Cancer Hospital
06/27/2017
St. Jude recognized among hospitals that delivered exceptionally high-quality care among multiple specialties.
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St. Jude Children’s Research Hospital adds new leadership members for Clinical Trials Administration
06/22/2017
Denise Roe and Tangie Thomas will join as leaders in the growing Clinical Trials Administration department.
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Researchers create a ‘Rosetta Stone’ to decode immune recognition
06/21/2017
A new algorithm helps decode how T cells recognize antigens, which should aid efforts to harness the immune system against cancer and infections.
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Researchers identify a key controller of biological machinery in cell’s ‘antenna’
06/06/2017
Discovery of new molecular control switches for cellular machinery offers invaluable new research pathways for understanding and treating diseases.
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Chronic health conditions among childhood cancer survivors decrease
06/02/2017
Research from Childhood Cancer Survivor Study finds improvements in therapies have reduced the incidence of serious chronic late health effects in survivors.
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ASCO 2017 will feature research from a variety of St. Jude experts
05/26/2017
St. Jude experts present pediatric oncology and survivorship research at the annual meeting of the American Society of Clinical Oncology.
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A new strategy reported to combat influenza and speed recovery
05/23/2017
Influenza hijacks cell metabolism and revs up production of new virus. The investigational cancer drug BEZ235 reverses that and speeds flu recovery.
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St. Jude Children's Research Hospital CEO and a hospital faculty member recognized for contributions to cancer research
05/18/2017
James R. Downing, M.D., and Charles Mullighan, MBBS, M.D., have received awards from prestigious cancer research institutions.
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St. Jude maps genome organization to link retinal development and retinoblastoma
05/03/2017
Epigenetic map reveals molecular switches that control development of both the normal retina and the eye cancer retinoblastoma.
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Researchers unlock an immunity ’black box’
04/18/2017
The immune machinery that drives the skin disease neutrophilic dermatosis (Sweet’s syndrome) reveals clues for taming the immune response
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Success of sensory cell regeneration raises hope for hearing restoration
04/11/2017
Manipulating two genes sparked regeneration of sensory hair cells in adult mice. The finding advances treatment of a leading cause of hearing loss.
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Time-lapse video reveals cells essential for 'birth' of blood stem cells
04/10/2017
Neural crest cells revealed as key to hematopoietic stem cell production in the body.
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Rescue protein gives doomed cells a stay of 'execution'
04/06/2017
Discovery of the protein that delays cell death could aid transplant survival and offer treatment for cancer, neurodegeneration and infection
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Study finds more childhood cancer survivors would likely benefit from genetic screening
04/03/2017
Learn what whole genome sequencing reveals about the lifetime cancer risk of childhood cancer survivors and who may benefit from genetic screening.
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St. Jude Researchers at AACR 2017
03/31/2017
Explore research being presented by St. Jude investigators at the annual meeting of the American Association for Cancer Research (AACR) in Washington, D.C.
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Caution needed for drugs in development for most common malignant pediatric brain tumor
03/21/2017
Inhibiting the Ezh2 enzyme may be counterproductive for treatment of certain cancers, including the aggressive brain tumor Group 3 medulloblastoma
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St. Jude names research tower for Donald Pinkel, M.D., in honor of his legacy of finding cures for childhood cancers
03/17/2017
Pioneering physician sets first cure rate for children with acute lymphoblastic leukemia (ALL)
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St. Jude Children's Research Hospital named to Fortune magazine’s ‘100 Best Companies to Work For’ for seventh consecutive year
03/09/2017
St. Jude recognized for having exceptional workplace culture based upon employee surveys and an in-depth questionnaire.
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New grant expands reach of St. Jude gene therapy program for "bubble boy" disease
02/23/2017
The new grant supports the opening of the St. Jude gene therapy protocol for X-linked SCID at the University of California, San Francisco (UCSF) Benioff Children's Hospital San Francisco.
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Stephen Gottschalk, M.D., named chair of the Department of Bone Marrow Transplantation and Cellular Therapy
01/30/2017
In his new position, Gottschalk will be responsible for management of the department’s clinical, research and educational activities.
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Research leads to new treatment recommendations for a high-risk pediatric leukemia
01/23/2017
Three genetic changes can help identify children with the high-risk leukemia AMKL likely to benefit from allogeneic stem cell transplants.
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Infant’s prolonged infection reveals mutation that helps bacteria tolerate antibiotics
01/03/2017
Prolonged infection in infant with leukemia led to discovery of a mutation in the stringent response pathway that helps bacteria tolerate antibiotics.
