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St. Jude researchers develop powerful interactive tool to mine data from cancer genome
12/29/2015
ProteinPaint gives researchers a free, interactive tool for advancing understanding of the mutations that lead to and drive pediatric cancer.
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St. Jude Children’s Research Hospital receives approval for Graduate School of Biomedical Sciences
12/22/2015
Tennessee Higher Education Commission unanimously approves St. Jude graduate school in biomedical sciences.
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Tumors hijack export pathway in cells to resist chemotherapy and fuel disease progression
12/18/2015
Scientists discover how aggressive sarcoma lays the groundwork for cancer progression and chemotherapy resistance along with a possible solution.
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St. Jude names Carlos Rodriguez-Galindo, M.D., director of International Outreach Program
12/09/2015
The St. Jude IOP will establish research goals to improve worldwide quality of care for children with cancer under Dr. Rodriguez-Galindo’s direction.
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Genetic variants tied to increased risk of bone complications in young leukemia patients
12/05/2015
Gene variants identified that leave young acute lymphoblastic leukemia patients at increased risk for osteonecrosis as a side effect of treatment.
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Early progress reported in designing drugs that target “disordered” proteins
12/01/2015
Small molecule drug discovery advances may aid hearing restoration by targeting an intrinsically disordered protein.
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New study suggests more than 8 percent of children with cancer have genetic predisposition
11/18/2015
Pediatric Cancer Genome Project determines nearly one in ten of children with cancer have mutations in genes associated with cancer predisposition.
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St. Jude Children’s Research Hospital employees named Top 40 Under 40
11/13/2015
Three individuals from St. Jude were recognized by the Memphis Business Journal for making a difference in their careers and the Memphis community.
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St. Jude and Scripps Research Institute Scientists Help Launch Human Dark Proteome Initiative
11/09/2015
An initiative has been launched to help advance the research of the dark proteome, proteins that control some cellular behavior.
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Inherited gene variation linked to an increased risk of the most common childhood cancer
10/27/2015
For two generations of one family, inherited variation in the ETV6 gene linked to an increased risk of childhood acute lymphoblastic leukemia (ALL).
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Computerized cognitive training improves childhood cancer survivors’ attention and memory
10/12/2015
Intensive, adaptive cognitive training presented as a video game was as effective as medication for improving the working memory of cancer survivors.
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Discovery provides insight into life-threatening respiratory distress in newborns
09/29/2015
Scientists identify lead for reducing risk of respiratory distress in newborns born to women who develop intrahepatic cholestasis of pregnancy (ICP).
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Newly identified mechanism solves enduring mystery of key element of cellular organization
09/24/2015
St. Jude study advances understanding of cellular organization and highlights a possible treatment strategy for degenerative diseases like ALS.
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Retinoids may increase effectiveness of targeted therapies against high-risk leukemia
08/27/2015
St. Jude scientists discover how mutations in the IKZF1 gene lead to high-risk leukemia and identify drugs that may help improve survival.
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Researchers reveal how a common mutation causes neurodegenerative disease
08/26/2015
Researchers show how the most common genetic cause of ALS and a related disorder disrupts normal cell function, results offer hope for targeted therapies.
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St. Jude Achieves Magnet Designation® for Nursing Services
08/20/2015
St. Jude Children’s Research Hospital has received designated Magnet status. Only 7 percent of all U.S. hospitals have received this designation.
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St. Jude Children’s Research Hospital names Keith Perry as Chief Information Officer
08/17/2015
Keith Perry has been named as St. Jude chief information officer (CIO) to provide strategic counsel and leadership for the hospital’s information technology initiatives.
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St. Jude Children's Research Hospital names Department of Computational Biology chair
08/05/2015
Jinghui Zhang, Ph.D., an international expert in the analysis of genomic data, will lead the growth of innovative effort in newly dedicated space supported by Brooks Brothers.
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Newly identified mechanism of p53-induced cell death could aid cancer therapy
07/30/2015
St. Jude scientists have discovered how the p53 protein works outside the cell nucleus to trigger cell death. The results could aid cancer therapy.
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Targeted therapy shows effectiveness against a subtype of the brain tumor medulloblastoma
07/29/2015
A subset of medulloblastoma tumors briefly stopped growing or disappeared during treatment with the targeted drug vismodegib.
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New analysis points the way to earlier diagnosis of chest tumors
07/22/2015
St. Jude researchers have discovered a potential new method for determining whether masses in the chest cavity are a fungal infection or a tumor without performing a biopsy.
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St. Jude names Charles Roberts, M.D., Ph.D., director of its Cancer Center
07/22/2015
Roberts, an internationally recognized leader in cancer epigenetics, will oversee the country’s only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children.
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St. Jude to Receive $12M in Grants from NIH
07/08/2015
Investigators at St. Jude receive grants from the NIGMS for a Center for Precision Medicine in Leukemia to optimize curative treatments, translate genomics, and inform genomics methods for other disease treatments.
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New measurements reveal differences between stem cells for treating retinal degeneration
07/02/2015
St. Jude scientists use new methods to show that one type of stem cell is superior to another for treating retinal degeneration in research that could advance such treatments
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St. Jude makes Fortune's "100 Best Workplaces for Millennials" list
06/23/2015
St. Jude Children's Research Hospital has ranked on Great Place to Work and Fortune's "100 Best Workplaces for Millennials" list.
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Re-engineered antibiotic shows potential for treatment of drug-resistant bacteria
06/19/2015
St. Jude scientists created a second-generation of spectinomycin to combat bacteria that are a common cause of respiratory and other infections.
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Eighteen genes identified that contribute to childhood brain tumor ependymoma
06/18/2015
St. Jude discovery lays the foundation for developing new chemotherapy agents and finds evidence that statins slow growth of ependymoma tumor cells.
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Discovery promises new treatments to thwart colon cancer
06/18/2015
Scientists at St. Jude discovered how an immune system protein called AIM2 plays a role in determining the aggressiveness of colon cancer.
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Changes in treatment extend the lifespan of long-term survivors of childhood cancer
05/31/2015
Evidence from the Childhood Cancer Survivor Study (CCSS) suggests that changes in childhood cancer treatment have reduced deaths from the late effects of cancer treatment and extended the lives of childhood cancer survivors. St. Jude Children’s Research Hospital investigators presented the research at the plenary session of the 2015 annual meeting of the American Society of Clinical Oncology (ASCO).
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St. Jude scientist named Howard Hughes Medical Institute investigator
05/19/2015
J. Paul Taylor, M.D., Ph.D., of St. Jude Children's Research Hospital, has been recognized as one of the nation’s leading biomedical researchers by the Howard Hughes Medical Institute.
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First cancer-promoting oncogenes discovered in rare brain tumor of children and adults
05/11/2015
Researchers have identified three genes that play a pivotal role in the brain tumor choroid plexus carcinoma (CPC), a discovery that lays the groundwork for more effective treatment of this rare, often fatal cancer.
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Childhood cancer treatment and age influence obesity risk for childhood cancer survivors
05/11/2015
Childhood cancer survivors – especially those whose treatment included brain irradiation or chemotherapy with glucocorticoids – are 14 percent more likely to be obese than their healthy peers.
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Tracking defects caused by brain tumor mutation yields insight to advance targeted therapy
05/08/2015
St. Jude Children’s Research Hospital scientists show that mutations in the DDX3X gene lead to different molecular defects; findings will aid efforts to develop more individualized therapy of medulloblastoma.
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Scientists dramatically improve method for finding common genetic alterations in tumors
05/04/2015
Results of the St. Jude Children’s Research Hospital-led study provide a target for developing novel therapies to tame the inflammation that drives autoinflammatory diseases.
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Discovery could help reverse glucocorticoid resistance in some young leukemia patients
05/04/2015
St. Jude Children’s Research Hospital study lays the foundation for more effective treatment of childhood leukemia and a wide range of other disorders using small molecules to reverse glucocorticoid resistance
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St. Jude Children’s Research Hospital opens seventh affiliate clinic
04/21/2015
Addition extends access to clinical trials at St. Jude to children beyond its physical walls through clinical, research and academic affiliations with medical centers in six states.
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Protein identified that serves as a “brake” on inflammation
04/21/2015
Study provides a target for developing novel therapies to tame the inflammation that drives autoinflammatory diseases
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St. Jude Children’s Research Hospital scientific director announces resignation
03/26/2015
Richard Gilbertson, M.D., Ph.D., to become director of the Cambridge Cancer Centre in England.
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Experiments reveal key components of the body's machinery for battling deadly tularemia
03/23/2015
St. Jude Children’s Research Hospital scientists have discovered major “switches” that activate the immune system to kill the bacterium, potentially leading to protective drugs and vaccines.
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Measuring treatment response proves to be a powerful tool for guiding leukemia treatment
03/19/2015
Investigators report measuring leukemia cells that persist in patient bone marrow in the early weeks of treatment helps identify high-risk patients.
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Scientists trace genomic evolution of high-risk leukemia
03/19/2015
Whole exome sequencing of 20 pediatric ALL patients yielded important insights into the genetic basis of ALL treatment failure. The findings may lead to early detection of the mutations that drive ALL relapse.
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St. Jude Children’s Research Hospital appoints new chair of Department of Radiation Oncology
03/17/2015
Thomas Merchant, D.O., Ph.D., to oversee radiotherapy programs for the treatment of childhood cancer.
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Researchers map "genomic landscape" of childhood adrenocortical tumors for the first time
03/06/2015
St. Jude Children’s Research Hospital scientists identify key molecular events in pediatric adrenocortical tumors; findings could help clinicians identify most malignant subtypes and lead to better treatment.
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Chromosomal rearrangement key to progress against aggressive infant leukemia
03/06/2015
St. Jude Children’s Research Hospital—Washington University Pediatric Cancer Genome Project study highlights need for targeted therapies against a rare infant leukemia with a poor prognosis. (James R. Downing, MD)
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St. Jude Children's Research Hospital makes FORTUNE's "100 Best Companies to Work For" list for fifth straight year
03/05/2015
St. Jude Children’s Research Hospital has been recognized for the fifth year in a row as one of FORTUNE magazine’s “100 Best Companies to Work For.”
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Sun damage causes genetic changes that predispose children and adolescents to melanoma
03/04/2015
The genetic basis of three pediatric melanoma subtypes have been identified; findings could lead to better diagnosis and treatment.
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Inherited gene variation leaves young leukemia patients at risk for peripheral neuropathy
02/24/2015
Research could help reduce side effects associated with the anti-cancer drug vincristine.
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Possible strategy identified to combat major parasitic tropical disease
02/18/2015
Report suggests neutralizing a single protein may aid fight against a parasitic tropical disease.
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Survivors of childhood cancer at risk for developing hormone deficiencies as adults
02/13/2015
Childhood cancer patients treated with cranial irradiation may have hormone deficiencies that impact health decades later.
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Inherited gene variations tied to treatment-related hearing loss in cancer patients
02/09/2015
Scientists have identified genetic variations associated with hearing loss in young cancer patients treated with cisplatin.
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St. Jude Children’s Research Hospital scientist honored for contributions to immunology
02/04/2015
Thirumala-Devi Kanneganti, Ph.D., is recognized by the American Association of Immunologists for outstanding research contributions.
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Inherited gene variation helps explain drug toxicity in patients of East Asian ancestry
01/26/2015
Scientists have linked inherited variations in a second gene to reduced tolerance of a key cancer drug.
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Tumor suppressor protein plays key role in maintaining immune balance
01/15/2015
Scientists show that the PTEN tumor suppressor protein is essential for proper regulatory T cell function.
