Selected Publications
Ahmed, Etzrodt, Dettinger, Kull, Loeffler, Hoppe, Chavez, Zhang, Ortega, Hilsenbeck, Nakajima, Pietras, Schroeder. Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation. JEM 2021 (in press).
Loeffler*, Schneiter*, Wang, Wehling, Kull, Lengerke, Manz, Schroeder. Asymmetric organelle inheritance predicts human blood stem cell fate. Blood Jul 27, 2021. PMID: 34314497; Citations: 1 - Impact Factor: 22.113
Wang*, Zhang*, Dettinger, Reimann, Kull, Loeffler, Manz, Lengerke, Schroeder. Cytokine combinations for human blood stem cell expansion induce cell-type- and cytokine-specific signaling dynamics. Blood Sep 9;138(10):847-857, 2021. PMID: 33988686; Citations: 1 - Impact Factor: 22.113
Chavez, Rabe, Loeffler, Higa, Hernandez, Mills, Ahmed, Gessner, Ke, Idler, Kim, Myers, Stevens, Jordan, Nakajima, Ashton, Welner, Schroeder, DeGregori, Pietras. PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress. JEM Jun 7;218(6):e20201169, 2021. PMID: 33857288; Citation: 0 – Impact Factor: 14.307
Dettinger, Wang, Ahmed, Zhang, Loeffler, Kull, Etzrodt, Lengerke, Schroeder. An automated microfluidic system for efficient capture of rare cells and rapid flow-free stimulation. Lab Chip Nov 10;20(22):4246-4254, 2020. PMID: 33063816; Citation: 0 – Impact Factor: 6.914
Peng, Lamm, Loeffler, Ahmed, Navab, Schroeder, Marr. Background and illumination correction for time-lapse microscopy data with correlated foreground. MICCAI Springer Cham 2020.
Ahmed, Kunz, Hoppe, Loeffler, Etzrodt, Camargo Ortega, Hilsenbeck, Anastassiadis, Schroeder. A novel GATA2 protein reporter mouse reveals hematopoietic progenitor cell types. Stem Cell Reports Aug 11;15(2):326-339, 2020. PMID: 32649900; Citations: 1 - Impact Factor: 5.6
Loeffler, Schneiter, Schroeder. Pitfalls and requirements in quantifying asymmetric mitotic segregation. ANYAS Apr;1466(1):73-82, 2020. PMID: 31814150; Citations: 1 - Impact Factor: 4.788
Loeffler, Wehling, Schneiter, Zhang, Müller-Bötticher, Hoppe, Hilsenbeck, Kokkaliaris, Endele, Schroeder. Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells. Nature Sep;573(7774):426-429, 2019. PMID: 31485073; Citations: 31 - Impact Factor: 41.577
Strasser, Hoppe, Loeffler, Kokkaliaris, Schroeder, Theis, Marr. Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm. Nature Communications Jul 12;9(1):2697, 2018. PMID: 30002371; Citations: 14 - Impact Factor: 12.353
Etzrodt, Ahmed, Hoppe, Loeffler, Skylaki, Hilsenbeck, Kokkaliaris, Kaltenbach, Stelling, Nerlov, Schroeder. Inflammatory signals directly instruct PU.1 in HSCs via TNF. Blood Feb 21;133(8):816-819, 2019. PMID: 30301719; Citations: 14 - Impact Factor: 15.132
Loeffler, Wang, Hopf, Hilsenbeck, Bourgine, Rudolf, Martin, Schroeder. Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating. Blood Mar 29;131(13):1425-1429, 2018. PMID: 29453290; Citations: 10 - Impact Factor: 15.132
Shepherd, Li, Wilson, Oedekoven, Li, Belmonte, Fink, Prick, Pask, Hamilton, Loeffler, Rao, Schroeder, Göttgens, Green, Kent. Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal. Blood Aug 23;132(8):791-803, 2018. PMID: 29991556; Citations: 6 - Impact Factor: 15.132
Dettinger, Frank, Etzrodt, Ahmed, Reimann, Trenzinger, Loeffler, Kokkaliaris, Schroeder, Tay. Automated Microfluidic System for Dynamic Stimulation and Tracking of Single-cells. Analytical Chemistry Sep 18;90(18):10695-10700, 2018. PMID: 30059208; Citations: 12 - Impact Factor: 6.350
Hastreiter, Skylaki, Loeffler, Reimann, Hilsenbeck, Hoppe, Coutu, Kokkaliaris, Schwarzfischer, Anastassiadis, Schwarzfischer, Anastassiadis, Theis, Schroeder. Inductive and Selective Effects of GSK3 and MEK Inhibition on Nanog Heterogeneity in Embryonic Stem Cells. Stem Cell Reports Jul 10;11(1):58-69, 2018. PMID: 29779897; Citations: 8 - Impact Factor: 5.499
Hilsenbeck, Schwarzfischer, Loeffler, Dimopoulos, Hastreiter, Marr, Theis, Schroeder. fastER: a user-friendly tool for ultrafast and robust cell segmentation in large-scale microscopy. Bioinformatics Jul 1;33(13):2020-2028, 2017. PMID: 28334115; Citations: 34 - Impact Factor: 5.481
Buggenthin, Buettner, Hoppe, Endele, Kroiss, Strasser, Schwarzfischer, Loeffler, Kokkaliaris, Hilsenbeck, Schroeder*, Theis*, Marr*. Prospective identification of hematopoietic lineage choice by deep learning. Nature Methods Apr;14(4):403-406, 2017. PMID: 28218899; Citations: 83 - Impact Factor: 26.919
Endele, Loeffler, Kokkaliaris, Hilsenbeck, Skylaki, Hoppe, Schambach, Stanley, Schroeder. CSF-1 induced Src signaling can instruct monocytic lineage choice. Blood Mar 23;129(12):1691-1701, 2017. PMID: 28159742; Citations: 8 - Impact Factor: 15.132
Hoppe, Schwarzfischer, Loeffler, Kokkaliaris, Hilsenbeck, Moritz, Endele, Filipczyk, Gambardella, Ahmed, Etzrodt, Coutu, Rieger, Marr, Strasser, Schauberger, Burtscher, Ermakova, Bürger, Lickert, Nerlov, Theis, Schroeder. Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios. Nature Jul 14;535(7611):299-302, 2016. PMID: 27411635; Citations: 119 - Impact Factor: 40.137
Hilsenbeck*, Schwarzfischer*, Skylaki*, Schauberger, Hoppe, Loeffler, Kokkaliaris, Hastreiter, Skylaki, Filipczyk, Strasser, Buggenthin, Feigelman, Krumsiek, van den Berg, Endele, Etzrodt, Marr, Theis**, Schroeder**. Software tools for single-cell tracking and quantification of cellular and molecular properties. Nature Biotechnology Jul 12;34(7):703-6, 2016. PMID: 27404877; Citations: 96 - Impact Factor: 41.667
Kokkaliaris, Drew, Endele, Loeffler, Hoppe, Hilsenbeck, Schauberger, Hinzen, Skylaki, Theodorou, Kieslinger, Lemischka, Moore, Schroeder. Identification of factors promoting ex vivo maintenance of hematopoietic stem cells by long-term single-cell quantification. Blood Sep 1;128(9):1181-92, 2016. PMID: 27365423; Citations: 21 - Impact Factor: 13.164
Pietras, Mirantes-Barbeito, Fong, Loeffler, Kovtonyuk, Zhang, Lakshminarasimhan, Chin, Techner, Will, Nerlov, Steidl, Manz, Schroeder, Passegué. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nature Cell Biology Jun;18(6):607-18, 2016. PMID: 27111842; Citations: 216 - Impact Factor: 20.06
Haas, Hansson, Klimmeck, Loeffler, Velten, Uckelmann, Wurzer, Prendergast, Schnell, Hexel, Santarella- Mellwig, Blaszkiewicz, Kuck, Geiger, Milsom, Steinmetz, Schroeder, Trumpp, Krijgsveldm, Essers. Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors. Cell Stem Cell Oct 1;17(4):422-34, 2015. PMID: 26299573; Citations: 192 - Impact Factor: 22.387
Filipczyk*, Marr*, Hastreiter*, Feigelman, Schwarzfischer, Hoppe, Loeffler, Kokkaliaris, Endele, Schauberger, Hilsenbeck, Skylaki, Hasenauer, Anastassiadis, Theis**, Schroeder**. Network plasticity of pluripotency transcription factors in embryonic stem cells. Nature Cell Biology Oct;17(10):1235-46, 2015. PMID: 26389663; Citations: 94 - Impact Factor: 18.699
Montrone, Kokkaliaris, Loeffler, Lechner, Kastenmüller, Schroeder, Ruepp. HSC-Explorer: A Curated Database for Hematopoietic Stem Cells. PLoS One Jul 30;8(7):e70348, 2013. PMID: 23936191; Citations: 10 - Impact Factor: 3.534
Last update: February 2022