Seth Karol, MD

Brogan P, Naden R, Ardoin SP, Cooper JC, De Benedetti F, Dicaire JF, Eleftheriou D, Feldman B, Goldin J, Karol SE, Price-Kuehne F, Skuse D, Stratakis CA, Webb N, Stone JH. The pediatric glucocorticoid toxicity index. Semin Arthritis Rheum Jul 14;56:152068, 2022. PMID: 35917759

Swanson HD, Hakim H, Hijano DR, Morton T, Cross S, Inaba H, Jeha S, Pui CH, Karol SE#. Vaccines against SARS-CoV-2 are safe to administer in patients with antibodies to pegaspargase. Cancer Med Jul 15, 20222. PMID: 35837830

Talleur A, Qudiemat A, Métais JY, Langfitt D, Mamcarz E, Crawford JC, Huang S, Cheng C, Hurley C, Madden R, Sharma A, Suliman AY, Srinivasan A, Velasquez MP, Obeng EA, Willis CM, Akel S, Karol SE, Inaba H, Bragg A, Zheng W, Zhou S, Schell S, Tuggle-Brown M, Cullins D, Patil SL, Li Y, Thomas PG, Zebley C, Youngblood BA, Pui CH, Lockey T, Geiger TL, Meagher MM, Triplett BM, Gottschalk S. Preferential expansion of CD8+ CD19-CAR T cells postinfusion and the role of disease burden on outcome in pediatric B-ALL. Blood Adv Apr 21, 2022. PMID: 35446934

Maron GM, Hijano DR, Epperly R, Su Y, Tang L, Hayden RT, Naik S, Karol SE, Gottschalk S, Triplett BM, Talleur AC. Infectious Complications in Pediatric, Adolescent and Young Adult Patients Undergoing CD19-CAR T Cell Therapy. Front Oncol Mar 9;12:845540, 2022. PMID: 35356197

Finch ER, Janke LJ, Li L, Payton MA, Jenkins DA, Crews KR, Relling MV, Karol SE#. Dasatinib does not exacerbate dexamethasone-induced osteonecrosis in murine models of acute lymphoblastic leukemia therapy. Pediatr Blood Cancer Dec 5:e29490, 2021. PMID: 34196166

van Atteveld JE, Mulder RL, van den Heuvel-Eibrink MM, Hudson MM, Kremer LCM, Skinner R, Wallace WH, Constine LS, Higham CE, Kaste SC, Niinimäki R, Mostoufi-Moab S, Alos N, Fintini D, Templeton KJ, Ward LM, Frey E, Franceschi R, Pavasovic V, Karol SE, Amin NL, Vrooman LM, Harila-Saari A, Demoor-Goldschmidt C, Murray RD, Bardi E, Lequin MH, Faienza MF, Zaikova O, Berger C, Mora S, Ness KK, Neggers SJCMM, Pluijm SMF, Simmons JH, Di Iorgi N. Bone mineral density surveillance for childhood, adolescent, and young adult cancer survivors: evidence-based recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Diabetes Endocrinol Sep;9(9):622-637, 2021. PMID: 34866312

Karol SE, Pei D, Smith CA, Liu Y, Yang W, Kornegay NM, Panetta JC, Crews KR, Cheng C, Finch ER, Inaba H, Metzger ML, Rubnitz JE, Ribeiro RC, Gruber TA, Yang JJ, Evans WE, Jeha S, Pui CH, Relling MV. Comprehensive analysis of dose intensity of acute lymphoblastic leukemia chemotherapy. Haematologica Jul 1, 2021. PMID: 34196166

Panetta JC, Liu Y, Bottiglieri T, Arning E, Cheng C, Karol SE, Yang JJ, Zhou Y, Inaba H, Pui CH, Jeha S, Relling MV. Pharmacodynamics of cerebrospinal fluid asparagine after asparaginase. Cancer Chemother Pharmacol Jun 25, 2021. PMID: 34170389

Janke LJ, Kim J, Payton MA, Jenkins DA, Cai X, Finch ER, Liu Y, Relling MV, Karol SE#. Effects of zoledronic acid on osteonecrosis and acute lymphoblastic leukemia treatment efficacy in preclinical models. Pediatr Blood Cancer Jun 14; e29183, 2021. PMID: 34121318

Jeha S, Choi J, Roberts KG, Pei D, Coustan-Smith E, Inaba H, Rubnitz JE, Ribeiro RC, Gruber TA, Raimondi SC, Karol SE, Qu C, Brady SW, Gu Z, Yang JJ, Cheng C, Downing JR, Evans WE, Relling MV, Campana D, Mullighan, CG, Pui CH. Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy. Blood Cancer Discovery Jul;2(4):326-337, 2021. PMID: 34250504

Liu Y, Yang W, Smith C, Cheng C, Karol SE, Larsen EC, Winick N, Carroll WL, Loh ML, Raetz EA, Hunger SP, Winter SS, Dunsmore KP, Devidas M, Yang JJ, Evans WE, Jeha S, Pui CH, Inaba H, Relling MV. Class II HLA Variants Associate with Risk of Pegaspargase Hypersensitivity. Clin Pharmacol Ther Mar 26, 2021. PMID: 33768542

Richardson R, Morin CE, Wheeler CA, Guo Y, Li Y, Jeha S, Inaba H, Pui CH, Karol SE, McCarville MB. Ultrasound has limited diagnostic utility in children with acute lymphoblastic leukemia developing pancreatitis. Pediatr Blood Cancer Jan;68(1):e28730, 2021. Epub 2020 Oct 27. PubMed PMID: 33111506

Yang W, Devidas M, Liu Y, Smith C, Dai Y, Winick N, Hunger SP, Loh ML, Raetz EA, Larsen E, Carroll WL, Winter SS, Dunsmore KP, Mattano LA, Relling MV, Karol SE#. Genetics of osteonecrosis in pediatric acute lymphoblastic leukemia and general populations. Blood Mar 18;137(11):1550-1552, 2021. PMID: 33106839

Zhang H, Liu AP, Devidas M, Lee SHR, Cao X, Pei D, Borowitz M, Wood B, Gastier-Foster JM, Dai Y, Raetz E, Larsen E, Winick N, Bowman WP, Karol S, Yang W, Martin PL, Carroll WL, Pui CH, Mullighan CG, Evans WE, Cheng C, Hunger SP, Relling MV, Loh ML, Yang JJ. Association of GATA3 polymorphisms with minimal residual disease and relapse risk in childhood acute lymphoblastic leukemia. J Natl Cancer Inst Apr 6;113(4):408-417, 2021. PMID: 32894760

Karol SE, Cooper TM, Mead PE, Crews KR, Panetta JC, Alexander TB, Taub JW, Lacayo NJ, Heym KM, Kuo DJ, Schiff DE, Bhojwani D, Ge Y, Klco JM, Ribeiro RC, Inaba H, Pui CH, Rubnitz JE. Safety, pharmacokinetics, and pharmacodynamics of panobinostat in children, adolescents, and young adults with relapsed acute myeloid leukemia. Cancer Nov 1;126(21):4800-4805, 2020. PMID: 32809242;

Liu Y, Panetta JC, Yang W, Karol SE, Cheng C, Yang JJ, Evans WE, Inaba H, Pui CH, Jeha S, Relling MV. Dosing-related Saturation of Toxicity and Accelerated Drug Clearance with Pegaspargase Treatment. Blood Dec 17;136(25):2955-2958, 2020. PubMed PMID: 32750103

Inaba H, Varechtchouk O, Neel MD, Ehrhardt MJ, Metzger ML, Karol SE, Ness KK, Ribeiro RC, Pui CH, Relling MV, Sandlund JT, Kaste SC. Whole-joint magnetic resonance imaging to assess osteonecrosis in pediatric patients with acute lymphoblastic lymphoma. Pediatr Blood Cancer Aug;67(8):e28336, 2020. PMID: 32472969

Karol SE#, Sun Y, Tang L, Pui CH, Ferrolino J, Allison KJ, Cross SJ, Evans WE, Crews KR, Jeha S, Wolf J#. Fluoroquinolone prophylaxis does not increase risk of neuropathy in children with acute lymphoblastic leukemia. Cancer Med Sep;9(18):6550-6555, 2020. PMID: 32710497

Finch ER, Payton MA, Jenkins DA, Cai X, Li L, Karol SE, Relling MV, Janke LJ. Fenofibrate reduces osteonecrosis without affecting antileukemic efficacy in dexamethasone treated mice. Haematologica Aug 1;106(8):2095-2101, 2020. PMID: 32675219

Panetta JC, Liu Y, Swanson HD, Karol SE, Pui CH, Inaba H, Jeha S, Relling MV. Higher plasma asparaginase activity after intramuscular than intravenous Erwinia asparaginase. Pediatr Blood Cancer Apr 23;:e28244, 2021. PMID: 32323890

Inaba H, Cao X, Chang JY, Karol SE, Panetta JC, Ness KK, Cheng C, Pui CH, Relling MV, Kaste SC. Incidence of hip and knee osteonecrosis and their associations with bone mineral density in children with acute lymphoblastic leukaemia. Br J Haematol May;189(4):e177-e181, 2020. PMID: 32207157

Karol SE, Alexander TB, Budhraja A, Pounds SB, Canavera K, Wang L, Wolf J, Klco JM, Mead PE, Das Gupta S, Kim SY, Salem AH, Palenski T, Lacayo NJ, Pui CH, Opferman JT, Rubnitz JE. Venetoclax in combination with cytarabine with or without idarubicin in children with relapsed or refractory acute myeloid leukaemia: a phase 1, dose-escalation study. Lancet Oncol Apr;21(4):551-560. PMCID: PMC7153631

DeFeo BM, Kaste SC, Li Z, Brinkman TM, Neel MD, Srivastava DK, Hudson MM, Robison LL, Karol SE, Ness KK. Long-Term Functional Outcomes Among Childhood Survivors of Cancer with a History of Osteonecrosis. Phys Ther Mar 10;100(3):509-522, 2020. PMID: 32044966

Autry RJ, Paugh SW, Carter R, Shi L, Liu J, Ferguson DC, Lau CE, Bonten EJ, Yang W, McCorkle JR, Beard JA, Panetta JC, Diedrich JD, Crews KR, Pei D, Coke CJ, Natarajan S, Khatamia A, Karol SE, Lopez-Lopez E, Diouf B, Smith C, Cogho Y, Hagiwara K, Roberts KG, Pounds S, Kornblau SM, Stock W, Paietta EM, Litzow MR, Inaba H, Mullighan CG, Jeha S, Pui CH, Cheng C, Savic D, Yu J, Gawad C, Relling MV, Yang JJ, Evans WE. Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia. Nat Cancer Mar;1(3):329-344, 2020. PMCID: PMC7467080

Williams HE, Howell CR, Chemaitilly W, Wilson CL, Karol SE, Nolan V, Smeltzer MP, Green DM, Ehrhardt MJ, Mulrooney DA, Pui CH, Hudson MH, Robison LL, Ness KK. Diabetes mellitus among adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort Study. Cancer Feb 15;126(4):870-878, 2020. PMCID: PMC6992468

Swanson HD, Panetta JC, Barker PJ, Liu Y, Inaba H, Relling MV, Pui CH, Karol SE#. Predicting success of desensitization after pegaspargase allergy. Blood Jan 2;135(1):71-75, 2020. PMCID: PMC6940200