Basic and Translational Research Faculty

Statistical methods in cancer genomics and genetics

Pediatric hematology and oncology; clinical trial design; survival analysis

Statistical genetics/genomics, statistical modeling of complex data

Statistical learning and computing methods for neurodegeneration

Causal inference, survival analysis, cancer survivorship

High-dimensional multi-omics, longitudinal modeling, statistical learning

Statistical analysis of complex imaging data

Develop theory and applied statistical methods for imperfectly recalled survival data

Basic, translational, clinical and population science

Phase I-II designs, survival analysis, Bayesian statistics

Develop Bayesian adaptive designs for Phase I-II clinical trials

Develop statistical methods for genomics studies

Design and analysis of clinical trials, survival analysis with long-term survivors

Clinical trials, robust methods, survival analysis, goodness-of-fit tests

Measurement error and classification, longitudinal modeling, complex epidemiologic study design

Develop statistical methods for precision medicine studies

Gene therapy for blood disorders

Immunotherapy for patients with solid tumors

Cancer immunotherapy, cell therapy, stem cell transplantation

CAR T-cell immunotherapy for brain tumors

Immunotherapy for hematological malignancies

Fundamental mechanisms of T cell biology

Molecular and cellular mechanisms of neural differentiation and maturation in health and disease

Dynamic regulation of inter-organelle communication

Organization of chromosomes through phase separation

Glia-neuron communication during brain development and disease

Autophagy and relevance to human disease

DNA damage responses in the nervous system

Genetics of pediatric neurological disease

Mechanisms of Hedgehog signal transduction

Regulation of cell death during hematopoiesis

Genome-editing technologies

Molecular genetics of neurological disease

Synthetic genome regulators

Covalent interactions between small molecules and proteins/RNA

Small-molecule transcription factor drug discovery

Chemical biology of protein machines

Chromatin dynamics during transcription

Exploiting the protein conformational landscape for ligand discovery

Development of new chemotherapeutic agents

Multi-scale modeling of biological and chemical data

Transcriptional control of cell identity and disease

OMICS integration and tumor heterogeneity by machine learning approaches

Computational methods and drug repositioning

Mathematical modeling of cancer initiating events

Systems biology, functional genomics and immuno-oncology

Genomic sequence analysis and visualization

Multi-omics and biomedical data visualization

Molecular, cellular and developmental pathogenesis of pediatric high-grade glioma

Functional organization of spinal interneurons

Growth control during neural tube development

Mechanisms of skeletal muscle aging, protein homeostasis, and myokines

Retinal development and retinoblastoma

Regulatory mechanisms of neural progenitors in brain development, diseases, & evolution

Molecular mechanisms of synaptic membrane fission events

Pediatric brain tumors; cancer epigenetics; therapeutics; models

Control of neuronal death and differentiation

Integrative genomics and molecular features of pediatric brain tumors

Epigenetic regulation of stem cell functions

Proteomics to ubiquitin biology and human disease

Spatial Omics

Molecular and organizational diversity of neuromodulatory circuits and their role in neuropsychiatric disease

Cell polarity in neuron precursor differentiation

Molecular mechanisms of the synaptic vesicle cycle

Neural circuits of learning, memory and their dysfunction in neuropsychiatric disease

Pediatric neuro-oncology and cancer survivorship

HPV vaccination; implementation science; partnered and engaged research

Hypothalamic/pituitary dysfunction in childhood cancer survivors

Late effects of childhood cancer therapy

Patient-reported outcomes measurement for childhood cancer

Health outcomes after childhood cancer

Cardiovascular outcomes of cancer therapy

Functional limitations among cancer survivors

Genomic basis of pediatric cancer outcomes

Genetic epidemiology of pediatric cancer and survivorship

Late effects of childhood cancer therapy

Genetics and risk of therapy-related outcomes

Global pediatric health, hospital quality of care, critical care in pediatric oncology, and clinical prediction scores

Global pediatric medicine

Infectious Diseases International Outreach

Pediatric hematology and oncology; clinical trial design; survival analysis

Global pediatric oncology; clinical effectiveness; health disparities; pediatric solid tumors

Childhood leukemias, developmental therapeutics

International outreach, rare tumors, treatment adherence

Global pediatric oncology; evidence-based education; pediatric CNS tumors

Infectious diseases, global health

Low grade gliomas, global health, telemedicine and retinoblastoma

Global medicine; pediatric solid tumors

Global pediatric cancer epidemiology

Genomic approaches to studying cis-regulatory modules in hematopoiesis

Vascular/hematopoietic development and leukemia

Inherited and acquired blood disorders

Bone marrow niche function in hematopoiesis

Inherited Bone Marrow Failure Disorders

Cancer stem cells & clonal hematopoiesis

Cellular and molecular regulation of hematopoietic stem cell in vivo repopulating activity, hematopoietic stem cell development and specification

Advancing genome editing and protein engineering technologies for therapeutics

Blood development and associated diseases

Inherited bone marrow failure and MDS predisposition syndromes

Novel genome engineering strategies to treat hemoglobinopathies

Emergence and evolution of bacterial pathogens

Translational immunology, immunotherapy, and immunoinformatics

Bacterial genomics and pathogenesis

Respiratory viruses: disease, cures & prevention

Pathogenesis of influenza and enteric virus infections

Innate and adaptive immunity to influenza

Bacterial pathogenesis and host response to infection

Pathogenesis of pneumococcal infection

Influenza virus pathogenicity

Cellular signaling in innate and adaptive immunity

Transcriptional and epigenetic basis of T cell biology

Apoptosis, autophagy and mitochondria

Investigating Neuro-Immune Interactions in Health and Disease

Mechanisms of host defense and inflammation

Innate and adaptive immunity to influenza

T cell memory differentiation and exhaustion

Unraveling the immune receptor networks in T cell anti-tumor immunity

Pathology/vaccine-induced immunity, nuclear hormones

Microbiome dynamics in immunocompromised patients and infants

Viral respiratory and perinatal infections

Viral respiratory infections, early life immunity

Immunity and pathogenesis of respiratory viruses

Pediatric neuro-oncology and cancer survivorship

Pediatric cancer survivorship

Transcriptional and epigenetic control in neuroblastoma

Late effects of childhood cancer therapy

Pediatric bone sarcomas

Cellular and molecular origins of rhabdomyosarcoma

Health outcomes after childhood cancer

The role of the microenvironment in cancer metastasis

Cardiovascular outcomes of cancer therapy

Metabolism in development and cancer

Heritable cancers and primary immunodeficiency syndromes

Myeloid malignancies and bone marrow failure syndromes

Tumor recurrence in pediatric rhabdomyosarcoma

SWI/SNF (BAF) chromatin remodeling/tumor suppressor

High risk pediatric solid tumors

The molecular pathology of acute leukemia

Immune system regulation and autoimmunity

Genomic and functional characterization of acute myeloid leukemia

Genomics, experimental modeling and preclinical therapeutics of acute leukemia

Genome instability, neurodegeneration, brain transcriptomics

Regulation of normal and malignant hematopoiesis

p53 function in tumor suppression & tumorigenesis

Hypothalamic/pituitary dysfunction in childhood cancer survivors

Functional limitations among cancer survivors

Endocrine effects of cancer therapy

Pharmacogenomics, pharmacoepidemiology, and outcomes research

Cancer vulnerabilities arising from genomic alterations

Pharmacometabolomic and pharmacometric approaches to tailor therapy

Understanding antibiotic resistance and persistence using bacterial single-cell transcriptomics

Molecular and genetic basis of antifungal pharmacotherapy

Development, enhancement, and preservation of antifungal pharmacotherapy

Pharmacogenomics and cis-regulatory architecture of pediatric leukemia

ABC transporters and mitochondrial biology

Pharmacokinetics and anticancer drug development

Pharmacogenomics of anticancer agents and drug resistance

Stem cells in normal and malignant development

Psychosocial outcomes of childhood cancer

Improving cognitive outcomes for childhood cancer survivors

Sleep disruption and fatigue in children and youth with cancer

Neurobehavioral outcomes in infants and toddlers with early brain pathology, central nervous system directed therapy and rare neurodevelopmental/neurogenetic disorders; neurobehavioral assessment of infants and toddlers with acute neurologic injury

Neurocognitive outcomes in sickle cell disease

Neurobehavioral outcomes in children treated for cancer

Pediatric pain from a biopsychosocial perspective

Neurocognitive outcomes of pediatric cancer

Coping and adjustment in youth with cancer

Neurocognitive late effects; cancer survivorship; functional and structural neuroimaging

Health management and transition to adult care in sickle cell disease

Neurocognitive outcomes in children with cancer

Acute neurological injury and cognitive outcomes associated with childhood cancer treatment

Cancer predisposition and adjustment in families of children with cancer

Promotion of healthy lifestyle behaviors in children with cancer and survivors of childhood cancer

Response assessment of immunotherapy and radiation therapy

Molecular MRI and MR spectroscopic techniques

Translational Imaging; radiopharmaceutical development

White matter injury and neurocognitive functioning

Multimodal functional brain imaging and neurorehabilitation

AI for medical imaging, including trustworthiness of deep learning models

Data science for discovery and personalized medicine

Examining structure-function relationships in macromolecular assemblies

Regulation of genome expression

Functional mechanisms of protein machineries

Genome engineering, organization, and architecture

Structural basis of tumor suppressor function

Molecular mechanisms of membrane signaling complexes

Dynamic protein complexes in signal transduction

Proteomics to ubiquitin biology and human disease

Developing a mechanistic understanding of signal translation at the cell membrane.

Neuroblastoma, renal tumors, and germ cell tumors; angiogenesis inhibition for cancer therapy

Renal tumors, neuroblastoma, Wilms tumorigenesis, cancer stem cells

Cancer epigenetics and targeted therapy

Genome editing in cancer development

Pediatric brain tumors: molecular pathways, mouse models, and pre-clinical trials

Tumor suppressor–dependent signaling networks